SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 12 GLY A 216
GLY A 219
ALA A 185
LEU A 236
VAL A 234
 None
 1.26A 1i9gA-5jqnA:
undetectable		 1i9gA-5jqnA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		4 / 5 ASP A 147
GLU A  41
LEU A 142
LEU A 143
 None
 1.19A 1u18B-5jqnA:
undetectable		 1u18B-5jqnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 11 VAL A  56
ALA A  58
ILE A  94
LEU A  42
ILE A  52
 None
 1.05A 3clbA-5jqnA:
undetectable		 3clbA-5jqnA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		4 / 8 ASP A 147
GLN A 113
MET A 153
GLU A 119
 None
 1.09A 3dh0A-5jqnA:
undetectable		 3dh0A-5jqnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 10 VAL A  56
ALA A  58
ILE A  94
LEU A  42
ILE A  52
 None
 1.04A 3hbbA-5jqnA:
undetectable		 3hbbA-5jqnA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 10 VAL A  48
GLY A 204
VAL A  56
GLN A  60
GLY A  46
 None
 1.21A 3km6A-5jqnA:
undetectable		 3km6A-5jqnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 9 VAL A  48
GLY A 204
VAL A  56
GLN A  60
GLY A  46
 None
 1.24A 3kmoA-5jqnA:
undetectable		 3kmoA-5jqnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		4 / 7 GLU A 119
TYR A 109
GLU A  41
TYR A  47
 None
 1.38A 3ku9B-5jqnA:
undetectable		 3ku9B-5jqnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 9 LEU A  36
ALA A 195
VAL A 234
LEU A 222
ILE A   3
 None
 1.34A 3wsjA-5jqnA:
undetectable		 3wsjA-5jqnA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		5 / 11 ARG A 138
GLY A 161
ALA A 158
PRO A 217
THR A 193
 None
 1.14A 4l1aA-5jqnA:
undetectable		 4l1aA-5jqnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		4 / 8 TYR A 146
TYR A 115
LEU A 171
TYR A 196
 None
 1.03A 4pwdC-5jqnA:
undetectable		 4pwdC-5jqnA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NY7_A_NCAA302_0
(AMIDASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		8 / 9 GLU A  41
TYR A  47
LYS A 111
TYR A 115
GLU A 119
TYR A 146
GLU A 149
LEU A 171
 None
 0.23A 5ny7A-5jqnA:
48.4		 5ny7A-5jqnA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NY7_A_NCAA303_0
(AMIDASE)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		6 / 6 ARG A  65
GLY A  85
PRO A  86
THR A  95
GLU A  97
SER A 108
 None
 0.14A 5ny7A-5jqnA:
48.4		 5ny7A-5jqnA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5jqn ALIPHATIC AMIDASE
(Nesterenkonia
sp.
AN1) 		3 / 3 TYR A 146
ASP A 147
GLN A 113
 None
 0.78A 6g1pA-5jqnA:
undetectable		 6g1pA-5jqnA:
22.89