SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 151
ILE A 158
SER A 216
ILE A 129
VAL A 161
 None
 1.06A 1z9hD-5jqxA:
undetectable		 1z9hD-5jqxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 234
GLY A 230
GLY A 115
THR A 276
LEU A 277
ILE A 237
 None
 1.08A 2oxtC-5jqxA:
undetectable		 2oxtC-5jqxA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 234
ALA A 226
LEU A 223
PRO A 224
 None
 0.99A 3bgdA-5jqxA:
undetectable		 3bgdA-5jqxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ASN A 139
ASP A 136
GLU A 265
SER A  60
 None
 1.48A 3p2kC-5jqxA:
undetectable		 3p2kC-5jqxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 PRO A  67
SER A  66
ILE A  65
VAL A 145
ILE A  33
 None
 1.19A 3rf4A-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4A-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 SER A  46
ILE A  45
VAL A 145
VAL A 149
ILE A 133
 None
 1.33A 3rf4A-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4A-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  33
PRO A  67
SER A  66
ILE A  65
VAL A 145
 None
 1.17A 3rf4A-5jqxA:
undetectable
3rf4B-5jqxA:
undetectable		 3rf4A-5jqxA:
15.67
3rf4B-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 133
SER A  46
ILE A  45
VAL A 145
VAL A 149
 None
 1.37A 3rf4A-5jqxA:
undetectable
3rf4B-5jqxA:
undetectable		 3rf4A-5jqxA:
15.67
3rf4B-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  33
PRO A  67
SER A  66
ILE A  65
VAL A 145
 None
 1.15A 3rf4B-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4B-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 133
SER A  46
ILE A  45
VAL A 145
VAL A 149
 None
 1.33A 3rf4B-5jqxA:
undetectable
3rf4C-5jqxA:
undetectable		 3rf4B-5jqxA:
15.67
3rf4C-5jqxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  92
ILE A  62
ILE A  89
GLU A  55
VAL A  78
 None
 1.01A 3tmzA-5jqxA:
undetectable		 3tmzA-5jqxA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  89
ARG A  90
ILE A  92
ALA A  91
 None
 0.86A 4lv9B-5jqxA:
undetectable		 4lv9B-5jqxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 315
GLY A 115
GLU A 116
ARG A 280
 None
 1.17A 5cdqA-5jqxA:
undetectable
5cdqB-5jqxA:
undetectable
5cdqC-5jqxA:
undetectable		 5cdqA-5jqxA:
23.09
5cdqB-5jqxA:
23.15
5cdqC-5jqxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 285
ALA A 275
PRO A 227
THR A 239
SER A 279
 None
 1.40A 5hfjC-5jqxA:
undetectable		 5hfjC-5jqxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 194
LEU A 278
SER A 270
ALA A 275
 None
 1.10A 5uunA-5jqxA:
undetectable		 5uunA-5jqxA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 184
VAL A 273
MET A 269
 3PG  A 401 (-3.3A)
None
3PG  A 401 (-3.5A)
 0.60A 5ycpA-5jqxA:
undetectable		 5ycpA-5jqxA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 160
TYR A 213
GLU A 232
THR A 239
 None
 1.24A 6c71B-5jqxA:
undetectable		 6c71B-5jqxA:
14.02