SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
4 / 6 ALA A  35
LEU A  54
LEU A  78
LEU A  45
None
0.99A 1mt1D-5jr3A:
undetectable
1mt1E-5jr3A:
undetectable
1mt1D-5jr3A:
15.52
1mt1E-5jr3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 PHE A 193
GLY A 189
GLY A 191
THR A 214
PHE A 156
None
SAH  A 401 ( 3.8A)
None
SAH  A 401 ( 4.5A)
4MU  A 402 (-4.8A)
1.13A 1nv8A-5jr3A:
11.7
1nv8A-5jr3A:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
8 / 12 GLY A 187
GLY A 188
GLY A 189
GLU A 210
ASP A 237
PHE A 238
ASN A 257
TRP A 258
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.2A)
None
0.46A 1qzzA-5jr3A:
38.7
1qzzA-5jr3A:
53.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
6 / 12 GLY A 188
GLU A 210
ASP A 237
PHE A 238
ASN A 257
TRP A 258
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.2A)
None
1.00A 1qzzA-5jr3A:
38.7
1qzzA-5jr3A:
53.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
9 / 12 GLY A 187
GLY A 188
GLY A 189
GLU A 210
ASP A 237
PHE A 238
SER A 252
ASN A 257
TRP A 258
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.6A)
SAH  A 401 (-4.2A)
None
0.29A 1xdsA-5jr3A:
42.1
1xdsA-5jr3A:
53.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
7 / 12 GLY A 188
GLU A 210
ASP A 237
PHE A 238
SER A 252
ASN A 257
TRP A 258
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.6A)
SAH  A 401 (-4.2A)
None
1.12A 1xdsA-5jr3A:
42.1
1xdsA-5jr3A:
53.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
9 / 12 GLY A 187
GLY A 188
GLY A 189
GLU A 210
ASP A 237
PHE A 238
SER A 252
ASN A 257
TRP A 258
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.6A)
SAH  A 401 (-4.2A)
None
0.33A 1xdsB-5jr3A:
34.5
1xdsB-5jr3A:
53.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
6 / 12 GLY A 188
GLU A 210
ASP A 237
PHE A 238
ASN A 257
TRP A 258
SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.2A)
None
1.03A 1xdsB-5jr3A:
34.5
1xdsB-5jr3A:
53.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
4 / 6 THR A  58
ARG A  57
ASP A 108
THR A 110
None
SO4  A 404 (-3.1A)
None
None
1.23A 2okcB-5jr3A:
10.6
2okcB-5jr3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 ASP A 185
GLY A 187
GLY A 189
GLY A 192
VAL A 254
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 ( 4.4A)
0.71A 2oxtD-5jr3A:
8.2
2oxtD-5jr3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 11 GLY A 187
GLY A 189
GLU A 210
ASP A 237
PHE A 253
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
4MU  A 402 ( 4.1A)
0.46A 3dxyA-5jr3A:
10.7
3dxyA-5jr3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 VAL A 186
GLY A 187
GLY A 189
GLU A 210
ASP A 237
None
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
0.70A 3fuuA-5jr3A:
9.9
3fuuA-5jr3A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
4 / 5 GLU A 225
LEU A 222
GLN A 164
GLY A 191
None
1.07A 3pp1A-5jr3A:
undetectable
3pp1A-5jr3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 LEU A 274
LEU A 346
ALA A 172
ALA A 174
TYR A 175
None
1.10A 3vw7A-5jr3A:
undetectable
3vw7A-5jr3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 LEU A 160
GLY A 187
GLY A 189
PHE A 238
TRP A 258
SAH  A 401 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
None
0.66A 4a6eA-5jr3A:
32.2
4a6eA-5jr3A:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 LEU A 184
ALA A 218
VAL A 233
GLY A 188
GLY A 191
None
None
SO4  A 405 (-3.7A)
SAH  A 401 ( 3.7A)
None
0.90A 4rn6B-5jr3A:
undetectable
4rn6B-5jr3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 SER A 252
GLY A 191
GLY A 189
ASP A 232
VAL A 231
SAH  A 401 (-2.6A)
None
SAH  A 401 ( 3.8A)
None
None
1.00A 5kpcB-5jr3A:
13.1
5kpcB-5jr3A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
4 / 7 GLY A 187
GLU A 210
ASP A 237
PHE A 238
SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
0.66A 5mvsA-5jr3A:
11.2
5mvsA-5jr3A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
4 / 8 GLY A 187
GLU A 210
ASP A 237
PHE A 238
SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
0.70A 5mvsB-5jr3A:
11.1
5mvsB-5jr3A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 10 VAL A 186
GLY A 187
GLU A 210
ASP A 237
ASN A 257
None
SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-4.2A)
1.04A 5x6yB-5jr3A:
3.1
5x6yB-5jr3A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 ALA A 161
GLY A 187
GLY A 189
PHE A 238
TRP A 258
None
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
None
1.17A 6clxA-5jr3A:
33.1
6clxA-5jr3A:
38.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 ASP A 157
GLY A 187
GLY A 189
PHE A 238
TRP A 258
None
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
None
0.55A 6clxA-5jr3A:
33.1
6clxA-5jr3A:
38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
4 / 6 LEU A 302
TYR A 342
ASP A 287
GLN A 334
None
4MU  A 402 ( 4.6A)
None
None
1.38A 6djzC-5jr3A:
undetectable
6djzC-5jr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius)
5 / 12 ASP A 185
GLY A 187
GLY A 189
ASP A 237
PHE A 238
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.4A)
0.76A 6nj9K-5jr3A:
9.4
6nj9K-5jr3A:
21.33