SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 ALA A  62
ALA A  63
LEU A  68
VAL A  22
LEU A 109
 None
 0.92A 1fm9A-5jr4A:
undetectable		 1fm9A-5jr4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 ALA A  62
ALA A  63
LEU A  68
VAL A  22
LEU A 109
 None
 0.97A 1k74A-5jr4A:
undetectable		 1k74A-5jr4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 ILE A 231
ASP A 203
SER A 270
ILE A 272
LEU A 197
 None
 1.24A 1rh3A-5jr4A:
undetectable		 1rh3A-5jr4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 ALA A  62
ALA A  63
LEU A  68
VAL A  22
LEU A 109
 None
 0.94A 1xiuB-5jr4A:
undetectable		 1xiuB-5jr4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 LEU A 129
ILE A 126
ALA A 127
VAL A  67
VAL A  75
 None
 1.10A 2g78A-5jr4A:
undetectable		 2g78A-5jr4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 5 GLN A 133
THR A 134
GLU A  89
THR A  90
 GOL  A 301 (-4.0A)
None
None
None
 1.36A 3glqA-5jr4A:
undetectable		 3glqA-5jr4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 5 GLN A 133
THR A 134
GLU A  89
THR A  90
 GOL  A 301 (-4.0A)
None
None
None
 1.39A 3glqB-5jr4A:
undetectable		 3glqB-5jr4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 ALA A  62
ALA A  63
LEU A  68
VAL A  22
LEU A 109
 None
 1.00A 3h0aA-5jr4A:
undetectable		 3h0aA-5jr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 5 GLN A 133
THR A 134
GLU A  89
THR A  90
 GOL  A 301 (-4.0A)
None
None
None
 1.45A 3n58A-5jr4A:
undetectable		 3n58A-5jr4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 8 TYR A 278
ASP A 162
VAL A 274
LEU A 193
 None
 1.09A 4f8hA-5jr4A:
undetectable
4f8hB-5jr4A:
undetectable		 4f8hA-5jr4A:
21.73
4f8hB-5jr4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 8 TYR A 278
ASP A 162
VAL A 274
LEU A 193
 None
 1.10A 4f8hC-5jr4A:
undetectable
4f8hD-5jr4A:
undetectable		 4f8hC-5jr4A:
21.73
4f8hD-5jr4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 8 TYR A 278
ASP A 162
VAL A 274
LEU A 193
 None
 1.08A 4f8hD-5jr4A:
undetectable
4f8hE-5jr4A:
undetectable		 4f8hD-5jr4A:
21.73
4f8hE-5jr4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 8 VAL A 274
LEU A 193
TYR A 278
ASP A 162
 None
 1.09A 4f8hA-5jr4A:
undetectable
4f8hE-5jr4A:
undetectable		 4f8hA-5jr4A:
21.73
4f8hE-5jr4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 7 ALA A 119
SER A  70
LEU A  34
PHE A  71
 None
 1.03A 4uymA-5jr4A:
undetectable		 4uymA-5jr4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		3 / 3 TYR A 108
THR A 110
THR A  74
 None
 0.41A 5aoxB-5jr4A:
undetectable		 5aoxB-5jr4A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		3 / 3 TYR A 108
THR A 110
THR A  74
 None
 0.47A 5aoxE-5jr4A:
undetectable		 5aoxE-5jr4A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		4 / 7 ASP A  54
TYR A  48
PRO A  49
THR A  51
 GOL  A 301 (-3.3A)
None
None
None
 1.27A 5b6iA-5jr4A:
undetectable		 5b6iA-5jr4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH
(Escherichia
coli) 		5 / 12 ILE A 231
ASP A 203
SER A 270
ILE A 272
LEU A 197
 None
 1.10A 5hi6B-5jr4A:
undetectable		 5hi6B-5jr4A:
19.72