SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHC_B_AB1B9001_2 (PROTEASE RETROPEPSIN)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	5 / 12	GLY B 199 VAL B 162 GLY B 223 ILE B 224 ILE B 163	None	1.06A	2qhcB-5jr7B: undetectable	2qhcB-5jr7B: 15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D2T_B_1FLB500_1 (TRANSTHYRETIN)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	4 / 6	LYS B 216 ALA B 215 SER B 155 VAL B 213	None	1.07A	3d2tB-5jr7B: undetectable	3d2tB-5jr7B: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N0H_A_TOPA187_1 (DIHYDROFOLATE REDUCTASE)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	5 / 11	ILE B 163 ALA B 211 PHE B 198 LEU B 221 VAL B 162	None	1.03A	3n0hA-5jr7B: undetectable	3n0hA-5jr7B: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3V_A_TOPA187_1 (DIHYDROFOLATE REDUCTASE)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	5 / 12	ILE B 163 ALA B 211 PHE B 198 LEU B 221 VAL B 162	None	1.03A	3s3vA-5jr7B: undetectable	3s3vA-5jr7B: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O2B_B_LOCB503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	3 / 3	SER B 297 ALA B 339 VAL B 338	None	0.58A	4o2bA-5jr7B: undetectable	4o2bA-5jr7B: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP6_A_B40A601_1 (TRANSPORTER)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	4 / 5	ASP B 288 VAL B 281 PHE B 291 GLY B 323	None	1.04A	4xp6A-5jr7B: undetectable	4xp6A-5jr7B: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_C_ZOLC401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	5jr7	CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT (Bos taurus)	4 / 5	ASP B 141 ASP B 140 ARG B 144 GLN B 273	None	1.30A	6g31C-5jr7B: undetectable	6g31C-5jr7B: 13.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2QHC_B_AB1B9001_2","PROTEASE RETROPEPSIN","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",5,"GLY B 199;VAL B 162;GLY B 223;ILE B 224;ILE B 163","None","1.06A","2qhcB-5jr7B:undetectable","2qhcB-5jr7B:15.59"],["3D2T_B_1FLB500_1","TRANSTHYRETIN","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",4,"LYS B 216;ALA B 215;SER B 155;VAL B 213","None","1.07A","3d2tB-5jr7B:undetectable","3d2tB-5jr7B:18.35"],["3N0H_A_TOPA187_1","DIHYDROFOLATE REDUCTASE","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",5,"ILE B 163;ALA B 211;PHE B 198;LEU B 221;VAL B 162","None","1.03A","3n0hA-5jr7B:undetectable","3n0hA-5jr7B:21.55"],["3S3V_A_TOPA187_1","DIHYDROFOLATE REDUCTASE","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",5,"ILE B 163;ALA B 211;PHE B 198;LEU B 221;VAL B 162","None","1.03A","3s3vA-5jr7B:undetectable","3s3vA-5jr7B:21.55"],["4O2B_B_LOCB503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",3,"SER B 297;ALA B 339;VAL B 338","None","0.58A","4o2bA-5jr7B:undetectable","4o2bA-5jr7B:18.75"],["4XP6_A_B40A601_1","TRANSPORTER","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",4,"ASP B 288;VAL B 281;PHE B 291;GLY B 323","None","1.04A","4xp6A-5jr7B:undetectable","4xp6A-5jr7B:18.75"],["6G31_C_ZOLC401_0","GERANYLGERANYL PYROPHOSPHATE SYNTHASE","5jr7","CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT","Bos taurus",4,"ASP B 141;ASP B 140;ARG B 144;GLN B 273","None","1.30A","6g31C-5jr7B:undetectable","6g31C-5jr7B:13.21"]]