SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 THR A  71
PRO A  72
GLY A  73
THR A  78
 None
 0.87A 1h4oB-5jriA:
2.3		 1h4oB-5jriA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 PRO A 120
LYS A 109
ALA A 107
GLU A 102
 None
 1.44A 1qhyA-5jriA:
undetectable		 1qhyA-5jriA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A 103
ILE A 288
ALA A 129
THR A 131
VAL A  99
 None
None
None
FAD  A 401 (-4.0A)
None
 1.09A 2nnhA-5jriA:
undetectable		 2nnhA-5jriA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A  81
ALA A  35
ALA A 130
THR A 131
GLY A  94
 None
None
FAD  A 401 (-4.7A)
FAD  A 401 (-4.0A)
FAD  A 402 (-3.3A)
 1.05A 2ve3A-5jriA:
undetectable		 2ve3A-5jriA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A  81
ALA A  35
ALA A 130
THR A 131
GLY A  94
 None
None
FAD  A 401 (-4.7A)
FAD  A 401 (-4.0A)
FAD  A 402 (-3.3A)
 1.07A 2ve3B-5jriA:
undetectable		 2ve3B-5jriA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 SER A 117
LYS A 111
GLU A  97
TYR A 119
 FAD  A 402 ( 4.2A)
FAD  A 402 (-4.2A)
FAD  A 402 ( 4.2A)
None
 1.03A 2x7hA-5jriA:
3.1		 2x7hA-5jriA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 TRP A 270
VAL A 108
ARG A 123
 SO4  A 407 (-3.4A)
None
None
 0.89A 3b0wA-5jriA:
undetectable		 3b0wA-5jriA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 SER A 234
GLU A 229
TYR A 149
ASP A 230
 None
 1.25A 3zs3A-5jriA:
undetectable		 3zs3A-5jriA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 4 LEU A 227
ILE A 223
GLY A 235
PHE A 226
 None
 1.14A 4dc3A-5jriA:
4.8		 4dc3A-5jriA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLN A 282
THR A 277
THR A 131
LEU A 262
 None
None
FAD  A 401 (-4.0A)
None
 1.35A 4lvcC-5jriA:
2.5		 4lvcC-5jriA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 MET A 253
VAL A 236
LEU A 238
ILE A 223
LEU A 211
 None
 1.48A 5iepA-5jriA:
undetectable		 5iepA-5jriA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A 128
ILE A 315
THR A 124
VAL A 108
VAL A  96
 None
None
None
None
FAD  A 401 (-3.7A)
 1.43A 5jkwA-5jriA:
undetectable		 5jkwA-5jriA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 THR A 277
THR A 131
HIS A 260
LEU A 262
 None
FAD  A 401 (-4.0A)
FAD  A 401 ( 4.5A)
None
 1.31A 5utuH-5jriA:
3.4		 5utuH-5jriA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 LYS A 125
VAL A  19
ASP A  21
 SO4  A 404 (-4.4A)
None
None
 0.70A 6fgdA-5jriA:
4.9		 6fgdA-5jriA:
22.69