SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jrj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 ILE A 100
THR A  83
SER A  86
ILE A  87
LEU A 121
 None
 0.80A 1ddrA-5jrjA:
2.4		 1ddrA-5jrjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 9 ILE A 100
LEU A 222
CYH A 136
ALA A 132
LEU A 156
 None
 0.94A 1e7bA-5jrjA:
undetectable		 1e7bA-5jrjA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		6 / 10 ALA A 132
LEU A 185
SER A 188
LEU A 139
ALA A 138
ILE A 100
 None
 1.39A 1g5yC-5jrjA:
undetectable		 1g5yC-5jrjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 5 LEU A 282
GLY A 285
LYS A 293
TYR A 298
 None
 1.37A 1gtiF-5jrjA:
undetectable		 1gtiF-5jrjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 4 GLY A 279
ASP A 268
GLY A 274
THR A  49
 None
 1.07A 1hxbB-5jrjA:
undetectable		 1hxbB-5jrjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 ILE A 189
VAL A 196
ALA A 138
CYH A 136
VAL A 150
 None
 1.30A 2g72B-5jrjA:
undetectable		 2g72B-5jrjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 11 ALA A 259
ILE A  60
VAL A 253
LEU A  82
ILE A  69
 None
 1.23A 2h42A-5jrjA:
undetectable		 2h42A-5jrjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		3 / 3 ARG A 331
ARG A 324
ARG A 277
 None
 1.08A 2jb7A-5jrjA:
undetectable
2jb7B-5jrjA:
undetectable
2jb7C-5jrjA:
undetectable		 2jb7A-5jrjA:
18.26
2jb7B-5jrjA:
18.26
2jb7C-5jrjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 5 PRO A  74
ILE A 232
ARG A 233
ASP A 231
 None
 1.26A 2rhmD-5jrjA:
2.5		 2rhmD-5jrjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 7 ILE A  56
VAL A  39
GLY A  38
GLY A 335
 None
 0.77A 2wd9A-5jrjA:
undetectable		 2wd9A-5jrjA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 CYH A 136
ILE A 100
ILE A 148
LEU A 222
LEU A 133
 None
 1.13A 3em0B-5jrjA:
undetectable		 3em0B-5jrjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 4 GLY A 279
ASP A 268
GLY A 274
THR A  49
 None
 1.08A 3k4vC-5jrjA:
undetectable		 3k4vC-5jrjA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 5 ILE A 232
PHE A 267
ASP A 268
GLU A 248
 None
 1.06A 3kp6A-5jrjA:
undetectable
3kp6B-5jrjA:
undetectable		 3kp6A-5jrjA:
18.13
3kp6B-5jrjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 10 ILE A  71
ASP A  55
GLY A  50
SER A  51
PHE A 267
 None
 1.07A 4bwlC-5jrjA:
undetectable		 4bwlC-5jrjA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 ILE A 100
THR A  83
SER A  86
ILE A  87
LEU A 121
 None
 0.81A 4dfrA-5jrjA:
2.5		 4dfrA-5jrjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 LEU A  84
LEU A 114
ILE A 199
GLN A 201
THR A 109
 None
None
None
ATP  A 402 (-3.0A)
None
 1.04A 4f4dA-5jrjA:
undetectable		 4f4dA-5jrjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 ALA A 265
GLU A 280
GLY A 279
GLN A  85
GLY A 274
 None
 1.22A 4uilH-5jrjA:
undetectable
4uilL-5jrjA:
undetectable		 4uilH-5jrjA:
20.83
4uilL-5jrjA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.25A 4w5qA-5jrjA:
2.5		 4w5qA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.25A 4w5rA-5jrjA:
2.7		 4w5rA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.29A 4w5tA-5jrjA:
2.6		 4w5tA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.30A 4z4cA-5jrjA:
undetectable		 4z4cA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.27A 4z4fA-5jrjA:
2.8		 4z4fA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 5 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.27A 4z4gA-5jrjA:
undetectable		 4z4gA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 ASP A 146
ALA A 144
THR A 194
THR A 192
 None
 1.29A 4z4iA-5jrjA:
2.9		 4z4iA-5jrjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 11 THR A  81
ALA A  88
GLY A 115
ALA A 111
ASP A 107
 ADP  A 401 ( 3.6A)
None
None
None
ATP  A 402 ( 3.4A)
 1.35A 5bxnV-5jrjA:
undetectable
5bxnW-5jrjA:
undetectable		 5bxnV-5jrjA:
21.31
5bxnW-5jrjA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 7 TYR A  72
ILE A 199
GLY A  78
THR A 249
 None
None
ADP  A 401 ( 3.2A)
None
 0.99A 5esmA-5jrjA:
undetectable		 5esmA-5jrjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 8 SER A  48
LEU A 339
ILE A 326
ALA A 323
 None
 0.81A 5te8B-5jrjA:
undetectable		 5te8B-5jrjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 LEU A 133
PHE A 198
ILE A 100
ALA A  98
GLY A  66
 None
 1.00A 5veuA-5jrjA:
undetectable		 5veuA-5jrjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		5 / 12 LEU A 133
PHE A 198
ILE A 100
ALA A  98
GLY A  66
 None
 1.02A 5veuH-5jrjA:
undetectable		 5veuH-5jrjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 GLU A 327
LYS A 329
GLU A 325
ALA A 323
 None
 1.08A 6an0A-5jrjA:
2.9		 6an0A-5jrjA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 6 LYS A 329
ARG A 324
GLU A 325
ALA A 323
 None
 1.20A 6an0A-5jrjA:
2.9		 6an0A-5jrjA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 5jrj PROTEIN RECA
(Herbaspirillum
seropedicae) 		4 / 5 ILE A 100
SER A 124
ALA A 138
LEU A 185
 None
 1.03A 6dwnA-5jrjA:
undetectable		 6dwnA-5jrjA:
15.43