SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 9 LEU H  21
LEU H  91
ILE H  44
LYS H 231
ILE H 103
 None
 1.34A 1hzeA-5jrpH:
undetectable
1hzeB-5jrpH:
undetectable		 1hzeA-5jrpH:
18.33
1hzeB-5jrpH:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 9 ILE H 103
LEU H  21
LEU H  91
ILE H  44
LYS H 231
 None
 1.34A 1hzeA-5jrpH:
undetectable
1hzeB-5jrpH:
undetectable		 1hzeA-5jrpH:
18.33
1hzeB-5jrpH:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 LEU H  91
ILE H 109
TRP H 139
TYR H  70
 None
 1.25A 2zlcA-5jrpH:
undetectable		 2zlcA-5jrpH:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ASP H 137
SER H 108
SER H  36
TYR H 110
 None
 1.03A 4lv9A-5jrpH:
undetectable
4lv9B-5jrpH:
undetectable		 4lv9A-5jrpH:
17.19
4lv9B-5jrpH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 7 TYR H 110
ASP H 137
SER H 108
SER H  36
 None
 1.01A 4lv9A-5jrpH:
undetectable
4lv9B-5jrpH:
undetectable		 4lv9A-5jrpH:
17.19
4lv9B-5jrpH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 TRP H  43
GLY H  42
ILE H  30
SER H  31
TYR H  60
 None
 1.19A 4rtpA-5jrpH:
undetectable		 4rtpA-5jrpH:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 TRP H  43
GLY H  56
ILE H  30
SER H  31
TYR H  60
 None
 1.38A 4rtrA-5jrpH:
undetectable		 4rtrA-5jrpH:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 TRP H  43
GLY H  42
ILE H  30
SER H  31
TYR H  60
 None
 1.18A 4rtsA-5jrpH:
undetectable		 4rtsA-5jrpH:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 CYH H 226
ASN H 229
THR H 195
VAL H 211
VAL H 212
 None
 1.49A 5wggA-5jrpH:
undetectable		 5wggA-5jrpH:
18.64