SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 8 SER A 113
VAL A 111
ALA A 169
GLU A 114
None
0.88A 1dmiA-5jryA:
undetectable
1dmiB-5jryA:
undetectable
1dmiA-5jryA:
21.88
1dmiB-5jryA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 TRP A 235
LEU A 454
LEU A 407
GLY A 406
PHE A 405
None
GOL  A 502 (-3.9A)
NDP  A 500 ( 4.8A)
None
None
1.10A 1hvyD-5jryA:
undetectable
1hvyD-5jryA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 9 LEU A 105
ALA A 160
GLY A 185
ALA A 186
LEU A 193
None
1.13A 1nr6A-5jryA:
undetectable
1nr6A-5jryA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 ILE A 433
VAL A 269
GLY A 410
ALA A 409
LEU A 397
None
1.09A 1r9oA-5jryA:
undetectable
1r9oA-5jryA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 ASP A  52
LYS A  55
ARG A  58
None
1.13A 1ra8A-5jryA:
undetectable
1ra8A-5jryA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 ALA A 165
THR A 108
PHE A 149
None
0.79A 2c6nB-5jryA:
undetectable
2c6nB-5jryA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 6 ARG A 334
SER A 331
SER A 333
GLU A 332
None
1.37A 2c8aC-5jryA:
undetectable
2c8aC-5jryA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 6 SER A 403
SER A 452
LEU A 407
GLY A 406
None
None
NDP  A 500 ( 4.8A)
None
0.91A 2j2pA-5jryA:
undetectable
2j2pC-5jryA:
undetectable
2j2pA-5jryA:
17.71
2j2pC-5jryA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 6 SER A 403
SER A 452
LEU A 407
GLY A 406
None
None
NDP  A 500 ( 4.8A)
None
0.90A 2j2pD-5jryA:
undetectable
2j2pF-5jryA:
undetectable
2j2pD-5jryA:
17.71
2j2pF-5jryA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 TRP A 235
LEU A 454
LEU A 407
GLY A 406
PHE A 405
None
GOL  A 502 (-3.9A)
NDP  A 500 ( 4.8A)
None
None
1.05A 2kceB-5jryA:
undetectable
2kceB-5jryA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 ARG A  79
VAL A  68
THR A 196
None
0.79A 2nmzA-5jryA:
undetectable
2nmzA-5jryA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 8 LEU A 105
ARG A  79
SER A 151
VAL A 184
None
None
NDP  A 500 (-4.7A)
None
1.18A 2qd2A-5jryA:
2.8
2qd2A-5jryA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 LEU A  87
GLN A 283
LEU A 176
PRO A 178
VAL A 205
None
1.28A 2qd4A-5jryA:
2.9
2qd4A-5jryA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 LEU A  87
GLN A 283
LEU A 176
PRO A 178
VAL A 205
None
1.35A 2qd4B-5jryA:
undetectable
2qd4B-5jryA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 11 ALA A 170
CYH A 147
GLY A 145
ILE A 144
VAL A 247
None
None
None
None
GOL  A 502 ( 4.9A)
1.31A 2uxpB-5jryA:
0.9
2uxpB-5jryA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 7 ASN A  12
SER A 204
ALA A  49
ALA A  50
ALA A  46
None
1.45A 3a2qA-5jryA:
undetectable
3a2qA-5jryA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 THR A 228
PHE A 381
GLU A 101
ALA A  91
PHE A 153
NDP  A 500 (-4.0A)
NDP  A 500 (-3.2A)
None
None
NDP  A 500 (-3.9A)
0.97A 3apxA-5jryA:
undetectable
3apxA-5jryA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 8 GLY A 410
VAL A 431
LEU A 426
ARG A 290
None
1.14A 3bgdB-5jryA:
3.5
3bgdB-5jryA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 ARG A  79
VAL A  68
THR A 196
None
0.78A 3k4vD-5jryA:
undetectable
3k4vD-5jryA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 LEU A 365
LEU A 305
LEU A 273
VAL A 436
ALA A 385
None
1.08A 3r9cA-5jryA:
undetectable
3r9cA-5jryA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 7 LEU A  37
ALA A  17
ASP A  20
TYR A   8
None
1.19A 3rodD-5jryA:
undetectable
3rodD-5jryA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 TYR A   8
ASP A  39
ASP A  44
None
0.74A 4a6eA-5jryA:
3.5
4a6eA-5jryA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 PHE A 405
ASP A 402
ARG A 377
None
0.86A 4eahF-5jryA:
undetectable
4eahF-5jryA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 PHE A 405
ASP A 402
ARG A 377
None
0.86A 4eahG-5jryA:
undetectable
4eahG-5jryA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 7 PHE A  80
ASN A  96
GLY A 100
THR A 103
None
0.66A 4ejjB-5jryA:
undetectable
4ejjB-5jryA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 11 ILE A 291
ALA A 274
LEU A 273
VAL A 269
LEU A 301
None
1.12A 4g1bB-5jryA:
5.0
4g1bB-5jryA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 4 ALA A  42
ALA A  45
ALA A  46
ALA A  49
None
0.10A 4oadA-5jryA:
undetectable
4oadA-5jryA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 4 ALA A  42
ALA A  45
ALA A  46
ALA A  49
None
0.09A 4oaeA-5jryA:
undetectable
4oaeA-5jryA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 4 ALA A  46
ALA A  49
ALA A  50
ALA A  53
None
0.13A 4oaeA-5jryA:
undetectable
4oaeA-5jryA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 GLY A 325
PRO A 326
GLN A 283
None
0.39A 4oltB-5jryA:
undetectable
4oltB-5jryA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 GLY A 325
PRO A 326
GLN A 283
None
0.25A 4qwpB-5jryA:
undetectable
4qwpB-5jryA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 MET A 360
GLN A 280
TYR A 279
None
1.13A 4udcA-5jryA:
undetectable
4udcA-5jryA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
None
1.25A 4w5oA-5jryA:
4.5
4w5oA-5jryA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 SER A 452
GLY A 447
GLY A 429
LEU A 454
GLY A 455
None
NDP  A 500 ( 4.7A)
None
GOL  A 502 (-3.9A)
None
0.99A 4yvgA-5jryA:
undetectable
4yvgA-5jryA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
None
1.24A 4z4cA-5jryA:
4.4
4z4cA-5jryA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
None
1.26A 4z4dA-5jryA:
2.7
4z4dA-5jryA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
4 / 5 PHE A 439
PRO A 437
VAL A 432
PHE A 412
None
1.24A 4z4eA-5jryA:
2.9
4z4eA-5jryA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
3 / 3 ASP A 271
ARG A 272
TYR A 268
None
1.03A 5a7mB-5jryA:
undetectable
5a7mB-5jryA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 LEU A 301
TYR A 376
VAL A 288
ALA A 385
LEU A 365
None
1.01A 5ikrB-5jryA:
undetectable
5ikrB-5jryA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 LEU A 301
TYR A 376
VAL A 288
ALA A 385
LEU A 365
None
1.10A 5jvzA-5jryA:
undetectable
5jvzA-5jryA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 GLU A 427
VAL A 428
ASP A 402
ALA A 409
GLY A 251
None
None
None
None
NDP  A 500 (-3.0A)
1.22A 5syeB-5jryA:
undetectable
5syeB-5jryA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans)
5 / 12 LEU A 198
GLN A  66
VAL A  68
HIS A  71
LEU A 193
None
1.29A 5ubbA-5jryA:
3.4
5ubbA-5jryA:
19.11