SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 6 LEU A 186
TYR A 185
ILE A 294
GLY A 217
 None
 0.87A 2du8A-5jsbA:
undetectable		 2du8A-5jsbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 6 LEU A 186
TYR A 185
ILE A 294
GLY A 217
 None
 0.88A 2du8B-5jsbA:
undetectable		 2du8B-5jsbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 5jsb MCL-1 INHIBITOR
(synthetic
construct) 		4 / 4 LYS B  68
LEU B  92
ALA B  71
LEU B   7
 None
 1.33A 2roxA-5jsbB:
undetectable		 2roxA-5jsbB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 5 PRO A 289
SER A 285
LEU A 179
SER A 183
 None
 1.16A 3ijxH-5jsbA:
undetectable		 3ijxH-5jsbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 5 PRO A 289
SER A 285
LEU A 179
SER A 183
 None
 1.23A 3iluH-5jsbA:
undetectable		 3iluH-5jsbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 8 SER A 178
ILE A 181
TRP A 312
PHE A 315
 None
 1.28A 4cx7A-5jsbA:
undetectable
4cx7B-5jsbA:
undetectable		 4cx7A-5jsbA:
19.37
4cx7B-5jsbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 5 LEU A 267
LEU A 298
THR A 259
TRP A 305
 None
 1.50A 4do3A-5jsbA:
undetectable		 4do3A-5jsbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 6 ARG A 303
ASP A 172
VAL A 297
ASP A 296
 None
 1.28A 4xqeA-5jsbA:
undetectable		 4xqeA-5jsbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 6 ARG A 303
ASP A 172
VAL A 297
ASP A 296
 None
 1.29A 4xqeB-5jsbA:
undetectable		 4xqeB-5jsbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 6 GLY A 217
SER A 269
VAL A 265
HIS A 224
 None
 0.98A 5ewuA-5jsbA:
undetectable		 5ewuA-5jsbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		4 / 6 GLY A 217
SER A 269
VAL A 265
HIS A 224
 None
 1.03A 5ewuB-5jsbA:
undetectable		 5ewuB-5jsbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
MCL-1 INHIBITOR
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY A 219
ASN A 223
ASN B  61
ASP B  93
ASP A 218
 None
 1.19A 5yn6A-5jsbA:
undetectable		 5yn6A-5jsbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
MCL-1 INHIBITOR
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY A 219
ASN A 223
ASN B  61
ASP B  93
ASP A 218
 None
 1.21A 5yniA-5jsbA:
undetectable		 5yniA-5jsbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
MCL-1 INHIBITOR
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLY A 219
ASN A 223
ASN B  61
ASP B  93
ASP A 218
 None
 1.22A 5ynmA-5jsbA:
undetectable		 5ynmA-5jsbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens) 		5 / 12 ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
 None
 1.10A 6b52A-5jsbA:
undetectable		 6b52A-5jsbA:
20.00