SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A  53
TRP A  61
TRP A  32
 None
 1.27A 1c4dA-5jscA:
undetectable
1c4dB-5jscA:
undetectable		 1c4dA-5jscA:
4.10
1c4dB-5jscA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 ARG A  87
ALA A 259
ASP A  98
GLY A 263
 None
 1.15A 1e7bA-5jscA:
undetectable		 1e7bA-5jscA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 ARG A  87
ALA A 259
ASP A  98
GLY A 263
 None
 1.11A 1e7cA-5jscA:
3.1		 1e7cA-5jscA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 109
ALA A 246
LEU A 245
VAL A  66
VAL A 127
 None
 0.94A 2zulA-5jscA:
undetectable		 2zulA-5jscA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 109
ALA A 246
LEU A 245
VAL A  66
VAL A 127
 None
 0.94A 3dmhA-5jscA:
undetectable		 3dmhA-5jscA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 9 ARG A 232
ALA A 196
VAL A 198
ILE A 111
GLY A 115
 None
 1.25A 3el4B-5jscA:
undetectable		 3el4B-5jscA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 4 LEU A 236
GLY A 237
GLY A 114
THR A 116
 None
 0.93A 3si7A-5jscA:
undetectable		 3si7A-5jscA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 8 PHE A  18
ALA A 314
THR A 255
LEU A  85
 None
 0.82A 4ejgB-5jscA:
undetectable		 4ejgB-5jscA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 113
ALA A 135
ILE A  78
LEU A 124
GLY A  75
 None
 1.25A 4l9qA-5jscA:
2.3		 4l9qA-5jscA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 4 LEU A  85
PHE A  18
LEU A 262
GLU A  88
 None
None
EDO  A 502 (-4.8A)
EDO  A 502 (-2.7A)
 1.29A 4p7nA-5jscA:
undetectable		 4p7nA-5jscA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 107
GLY A 105
LEU A 101
ILE A 111
SER A 112
 None
 1.06A 4qtuB-5jscA:
undetectable		 4qtuB-5jscA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 367
SER A 261
ALA A 327
ALA A 330
TYR A 373
 None
None
None
None
FAD  A 500 (-4.7A)
 1.31A 4u14A-5jscA:
3.4		 4u14A-5jscA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 5jsc PUTATIVE ACYL-COA
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 110
GLY A 107
SER A 108
LEU A 124
ASP A 177
 None
 1.50A 5vlmF-5jscA:
undetectable		 5vlmF-5jscA:
19.46