SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 TRP A 258
VAL A 256
TRP A 252
 None
None
SF4  A 302 (-3.9A)
 0.93A 1gmkC-5jsyA:
undetectable
1gmkD-5jsyA:
undetectable		 1gmkC-5jsyA:
4.30
1gmkD-5jsyA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 4 GLY A 237
ASP A 235
GLY A 231
THR A 227
 None
 1.02A 1hxbB-5jsyA:
undetectable		 1hxbB-5jsyA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 SER A 223
PHE A 226
TYR A 234
GLY A 237
LEU A 214
 None
None
None
None
SF4  A 301 (-4.7A)
 1.19A 1kglA-5jsyA:
undetectable		 1kglA-5jsyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 9 GLY A 267
PRO A 157
GLY A 158
GLY A 126
GLY A 125
 SF4  A 302 ( 4.6A)
None
None
None
None
 0.99A 1mxdA-5jsyA:
undetectable		 1mxdA-5jsyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 11 GLY A 267
PRO A 157
GLY A 158
GLY A 126
GLY A 125
 SF4  A 302 ( 4.6A)
None
None
None
None
 1.03A 1mxgA-5jsyA:
undetectable		 1mxgA-5jsyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 PHE A 203
LEU A 193
VAL A 154
ALA A 122
ALA A 117
 None
 1.34A 1q23A-5jsyA:
undetectable
1q23B-5jsyA:
undetectable		 1q23A-5jsyA:
22.22
1q23B-5jsyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 6 PRO A 160
GLY A 158
PRO A 157
ILE A 156
GLY A 119
 SF4  A 303 ( 4.0A)
None
None
None
SF4  A 303 (-3.6A)
 1.47A 1usqB-5jsyA:
undetectable		 1usqB-5jsyA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  58
LEU A  13
ALA A 104
GLU A 107
 None
 0.97A 1xvaA-5jsyA:
undetectable
1xvaB-5jsyA:
undetectable		 1xvaA-5jsyA:
23.12
1xvaB-5jsyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 LEU A  37
VAL A  36
VAL A  10
LEU A 116
LEU A 174
 None
 1.07A 2hc4A-5jsyA:
undetectable		 2hc4A-5jsyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		3 / 3 ARG A 198
SER A 195
TYR A 124
 None
 0.90A 2q2hA-5jsyA:
undetectable
2q2hB-5jsyA:
undetectable		 2q2hA-5jsyA:
18.79
2q2hB-5jsyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 10 PHE A  11
LEU A 144
VAL A 153
VAL A 140
LEU A 105
 None
 0.75A 3gwxA-5jsyA:
undetectable		 3gwxA-5jsyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 6 PRO A 110
GLY A 109
LEU A 144
ASN A 147
 None
 0.98A 3zqtA-5jsyA:
undetectable		 3zqtA-5jsyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 11 ALA A 117
GLY A 197
ILE A 156
ASP A 194
PRO A 271
 None
 1.13A 4dcmA-5jsyA:
undetectable		 4dcmA-5jsyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		5 / 12 ALA A 104
ALA A 122
ILE A  76
LEU A 144
GLY A 109
 None
 1.21A 4r38C-5jsyA:
undetectable		 4r38C-5jsyA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 6 LEU A  43
LEU A  74
VAL A  75
PHE A  11
 None
 1.19A 4uswA-5jsyA:
undetectable		 4uswA-5jsyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 4 ILE A 156
ASN A 155
ILE A  76
VAL A  75
 None
 1.25A 4uy87-5jsyA:
undetectable		 4uy87-5jsyA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 6 GLY A  20
THR A  19
VAL A  23
HIS A  46
 SF4  A 303 ( 3.9A)
None
None
None
 1.04A 5ewuA-5jsyA:
undetectable		 5ewuA-5jsyA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 7 ILE A  58
GLY A  92
PHE A 143
ASP A 103
 None
 1.13A 5hieA-5jsyA:
undetectable		 5hieA-5jsyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 6 THR A 243
GLY A 267
GLU A 270
ILE A 127
 SF4  A 302 (-4.3A)
SF4  A 302 ( 4.6A)
None
None
 0.89A 5kmfA-5jsyA:
undetectable
5kmfC-5jsyA:
undetectable		 5kmfA-5jsyA:
19.82
5kmfC-5jsyA:
19.82