SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 12 GLN A 103
TYR A 296
TYR A 278
GLY A 271
GLY A 269
 None
 1.20A 1httC-5jt8A:
undetectable		 1httC-5jt8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 12 GLN A 103
TYR A 296
TYR A 278
GLY A 271
GLY A 269
 None
 1.15A 1httD-5jt8A:
undetectable		 1httD-5jt8A:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		7 / 10 GLN A 113
GLY A 117
SER A 118
TRP A 120
PHE A 122
HIS A 263
ALA A 264
 CSO  A 119 ( 3.6A)
CSO  A 119 ( 3.9A)
CSO  A 119 ( 3.8A)
None
None
CSO  A 119 ( 4.0A)
CSO  A 119 ( 3.7A)
 0.26A 1stfE-5jt8A:
27.7
1stfI-5jt8A:
undetectable		 1stfE-5jt8A:
30.94
1stfI-5jt8A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 6 ILE A 177
VAL A 207
VAL A 268
ILE A 234
 CL  A 402 ( 4.4A)
None
None
None
 0.71A 1uwhA-5jt8A:
undetectable		 1uwhA-5jt8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 5 TYR A 242
TYR A  52
ILE A  47
GLY A 253
 NO3  A 405 (-4.5A)
None
None
None
 1.36A 2du8J-5jt8A:
undetectable		 2du8J-5jt8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 7 GLN A 113
GLY A 117
HIS A 263
TRP A 285
 CSO  A 119 ( 3.6A)
CSO  A 119 ( 3.9A)
CSO  A 119 ( 4.0A)
None
 0.42A 3ai8A-5jt8A:
24.8		 3ai8A-5jt8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 12 VAL A 265
ILE A 281
ASN A 283
HIS A 237
VAL A 297
 None
 1.11A 4a97B-5jt8A:
undetectable
4a97C-5jt8A:
undetectable		 4a97B-5jt8A:
22.73
4a97C-5jt8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 8 VAL A 268
TYR A 278
VAL A 232
ILE A 281
 None
 1.05A 4aftD-5jt8A:
undetectable
4aftE-5jt8A:
undetectable		 4aftD-5jt8A:
21.69
4aftE-5jt8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 11 ILE A  54
ASP A  59
PHE A  34
LYS A  35
ILE A   7
 None
 1.19A 4p68A-5jt8A:
undetectable		 4p68A-5jt8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 12 GLN A 103
TYR A 296
TYR A 278
GLY A 271
GLY A 269
 None
 1.20A 5e3iA-5jt8A:
undetectable		 5e3iA-5jt8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 11 GLN A 103
TYR A 296
TYR A 278
GLY A 271
GLY A 269
 None
 1.19A 5e3iB-5jt8A:
undetectable		 5e3iB-5jt8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		5 / 12 GLU A  62
ASP A 262
GLY A 238
ASN A 240
ASN A  55
 None
None
None
NO3  A 405 (-3.9A)
None
 1.44A 5kc4A-5jt8A:
undetectable		 5kc4A-5jt8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 5 LEU A 181
TYR A 187
LEU A 147
TYR A 175
 None
 1.39A 5ki6A-5jt8A:
undetectable		 5ki6A-5jt8A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 5 TYR A 210
SER A 169
ALA A 172
THR A 151
 None
NO3  A 404 (-3.8A)
None
None
 1.29A 5n0wB-5jt8A:
undetectable		 5n0wB-5jt8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		4 / 5 TYR A 210
SER A 169
ALA A 172
THR A 151
 None
NO3  A 404 (-3.8A)
None
None
 1.30A 5n4iA-5jt8A:
undetectable		 5n4iA-5jt8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		3 / 3 HIS A  44
GLU A  43
TRP A  40
 None
 1.08A 5odqD-5jt8A:
undetectable		 5odqD-5jt8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		3 / 3 HIS A  44
GLU A  43
TRP A  40
 None
 1.01A 5odrD-5jt8A:
undetectable		 5odrD-5jt8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5jt8 BLO T 1 ALLERGEN
(Blomia
tropicalis) 		3 / 3 TYR A 132
HIS A 206
MET A 176
 None
 1.08A 6af6A-5jt8A:
undetectable		 6af6A-5jt8A:
19.80