SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 579
PHE A 360
ILE A 635
PRO A 632
LEU A 316
 None
 1.04A 1dlsA-5jtaA:
undetectable		 1dlsA-5jtaA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 579
PHE A 360
ILE A 635
PRO A 632
LEU A 316
 None
 1.09A 1drfA-5jtaA:
undetectable		 1drfA-5jtaA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 344
VAL A 368
GLY A 308
LEU A 306
 None
 0.67A 1dzmA-5jtaA:
undetectable		 1dzmA-5jtaA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 1h4oA-5jtaA:
undetectable
1h4oB-5jtaA:
undetectable		 1h4oA-5jtaA:
13.65
1h4oB-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 1h4oB-5jtaA:
undetectable		 1h4oB-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.50A 1h4oC-5jtaA:
undetectable
1h4oD-5jtaA:
undetectable		 1h4oC-5jtaA:
13.65
1h4oD-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 1h4oD-5jtaA:
undetectable		 1h4oD-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 1h4oE-5jtaA:
undetectable
1h4oF-5jtaA:
undetectable		 1h4oE-5jtaA:
13.65
1h4oF-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_F_BEZF1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.47A 1h4oF-5jtaA:
undetectable		 1h4oF-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 1h4oH-5jtaA:
undetectable		 1h4oH-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.49A 1hd2A-5jtaA:
undetectable		 1hd2A-5jtaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 725
THR A 662
VAL A 182
 None
 0.89A 1hxbA-5jtaA:
undetectable		 1hxbA-5jtaA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 308
ASN A 348
GLY A 300
ALA A 297
LEU A 197
 None
 1.11A 1jg4A-5jtaA:
undetectable		 1jg4A-5jtaA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 637
HIS A 633
ARG A 652
ALA A 605
LEU A 598
 None
 1.22A 1mjlA-5jtaA:
undetectable
1mjlB-5jtaA:
undetectable		 1mjlA-5jtaA:
10.27
1mjlB-5jtaA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 637
HIS A 633
GLU A 599
ARG A 652
ALA A 605
 None
 1.11A 1mjlA-5jtaA:
undetectable
1mjlB-5jtaA:
undetectable		 1mjlA-5jtaA:
10.27
1mjlB-5jtaA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.50A 1oc3A-5jtaA:
undetectable		 1oc3A-5jtaA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_B_BEZB201_0
(PEROXIREDOXIN 5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 1oc3B-5jtaA:
undetectable		 1oc3B-5jtaA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 477
TRP A 578
ILE A 635
THR A 572
TYR A 312
 None
 1.41A 2gl0B-5jtaA:
undetectable
2gl0C-5jtaA:
undetectable		 2gl0B-5jtaA:
11.85
2gl0C-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 578
ILE A 635
THR A 572
TYR A 312
HIS A 477
 None
 1.39A 2gl0A-5jtaA:
undetectable
2gl0C-5jtaA:
undetectable		 2gl0A-5jtaA:
11.85
2gl0C-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 477
TRP A 578
ILE A 635
THR A 572
TYR A 312
 None
 1.41A 2gl0D-5jtaA:
undetectable
2gl0E-5jtaA:
undetectable		 2gl0D-5jtaA:
11.85
2gl0E-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 477
TRP A 578
ILE A 635
THR A 572
TYR A 312
 None
 1.35A 2gl0E-5jtaA:
undetectable
2gl0F-5jtaA:
undetectable		 2gl0E-5jtaA:
11.85
2gl0F-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 TRP A 578
ILE A 635
THR A 572
TYR A 312
HIS A 477
 None
 1.40A 2gl0D-5jtaA:
undetectable
2gl0F-5jtaA:
undetectable		 2gl0D-5jtaA:
11.85
2gl0F-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 414
HIS A 415
PRO A 416
HIS A 468
 None
 1.08A 2ombC-5jtaA:
undetectable
2ombD-5jtaA:
undetectable		 2ombC-5jtaA:
14.54
2ombD-5jtaA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
 None
 1.48A 2vl2A-5jtaA:
undetectable
2vl2C-5jtaA:
undetectable		 2vl2A-5jtaA:
14.58
2vl2C-5jtaA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 579
PHE A 360
ILE A 635
PRO A 632
LEU A 316
 None
 1.16A 2w3bB-5jtaA:
undetectable		 2w3bB-5jtaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 399
GLU A 394
ARG A 539
ILE A 506
 None
 1.45A 3e7gC-5jtaA:
undetectable
3e7gD-5jtaA:
undetectable		 3e7gC-5jtaA:
20.68
3e7gD-5jtaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 357
GLU A 424
THR A 425
HIS A 429
 None
 1.41A 3glqA-5jtaA:
undetectable		 3glqA-5jtaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 357
GLU A 424
THR A 425
HIS A 429
 None
 1.39A 3glqB-5jtaA:
undetectable		 3glqB-5jtaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 474
PRO A 358
ARG A 404
HIS A 415
 None
 1.48A 3ltwA-5jtaA:
undetectable		 3ltwA-5jtaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 357
GLU A 424
THR A 425
HIS A 429
 None
 1.36A 3n58A-5jtaA:
undetectable		 3n58A-5jtaA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 598
MET A 590
ASP A 549
 None
 0.81A 3v5wA-5jtaA:
undetectable		 3v5wA-5jtaA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 576
ASP A 557
ILE A 493
PHE A 574
LEU A 598
 None
 1.01A 4m2xA-5jtaA:
undetectable		 4m2xA-5jtaA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.31A 4w5qA-5jtaA:
undetectable		 4w5qA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.29A 4w5rA-5jtaA:
undetectable		 4w5rA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.29A 4w5tA-5jtaA:
undetectable		 4w5tA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 206
TYR A 238
ALA A 241
 None
 0.41A 4ybnA-5jtaA:
undetectable		 4ybnA-5jtaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.27A 4z4cA-5jtaA:
undetectable		 4z4cA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 591
ALA A 594
PHE A 574
THR A 573
 None
 1.38A 4z4fA-5jtaA:
undetectable		 4z4fA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.26A 4z4fA-5jtaA:
undetectable		 4z4fA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 591
ALA A 594
PHE A 574
THR A 573
 None
 1.34A 4z4hA-5jtaA:
undetectable		 4z4hA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 516
ALA A 507
LYS A 533
THR A 528
 None
 1.25A 4z4iA-5jtaA:
undetectable		 4z4iA-5jtaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 215
ASP A 212
ARG A 349
LEU A 353
 None
 1.04A 5hwaA-5jtaA:
undetectable		 5hwaA-5jtaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 608
SER A 611
ASP A 557
 None
 0.58A 5kvaB-5jtaA:
undetectable		 5kvaB-5jtaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 MET A 364
VAL A 368
LEU A 318
THR A 324
ALA A 327
 None
 1.06A 5vm8B-5jtaA:
undetectable		 5vm8B-5jtaA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 488
PRO A 403
SER A 412
ASP A 557
ARG A 482
 None
 1.14A 5zvgA-5jtaA:
undetectable		 5zvgA-5jtaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5jta NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 488
PRO A 403
SER A 412
ASP A 557
ARG A 482
 None
 1.13A 5zvgB-5jtaA:
undetectable		 5zvgB-5jtaA:
19.76