SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jtv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 PHE A 283
PHE A 324
LEU A 238
VAL A 242
PHE A 264
 None
 1.26A 1q23A-5jtvA:
undetectable
1q23B-5jtvA:
undetectable		 1q23A-5jtvA:
16.90
1q23B-5jtvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 PHE A 283
PHE A 324
LEU A 238
VAL A 242
PHE A 264
 None
 1.26A 1q23D-5jtvA:
undetectable
1q23E-5jtvA:
undetectable		 1q23D-5jtvA:
16.90
1q23E-5jtvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 11 PHE A 283
PHE A 324
LEU A 238
VAL A 242
PHE A 264
 None
 1.27A 1q23G-5jtvA:
undetectable		 1q23G-5jtvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 11 PHE A 283
PHE A 324
LEU A 238
VAL A 242
PHE A 264
 None
 1.20A 1q23J-5jtvA:
undetectable		 1q23J-5jtvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 GLU A 317
ARG A 325
LYS A 327
ASP A 346
 None
 1.49A 1rr8C-5jtvA:
undetectable		 1rr8C-5jtvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 4 LEU A 232
PRO A 399
ILE A 320
LEU A 238
 None
 1.12A 1ya4B-5jtvA:
undetectable		 1ya4B-5jtvA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 6 PHE A1063
ILE A1011
VAL A1020
PHE A1017
 None
 0.82A 2cizA-5jtvA:
undetectable		 2cizA-5jtvA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 8 LEU A 528
LYS A 476
ASN A 470
LEU A 469
 None
 1.16A 2xn3A-5jtvA:
undetectable
2xn3B-5jtvA:
undetectable		 2xn3A-5jtvA:
19.97
2xn3B-5jtvA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 4 ARG A 262
ASP A 482
GLY A 220
THR A 280
 None
 1.37A 3k4vB-5jtvA:
undetectable		 3k4vB-5jtvA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 10 GLY A 212
LYS A 209
GLN A 268
PRO A 471
PHE A 234
 None
 1.35A 4j4vB-5jtvA:
undetectable		 4j4vB-5jtvA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 6 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 1.00A 4o1zA-5jtvA:
undetectable		 4o1zA-5jtvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 ILE A 949
PRO A1006
HIS A1081
VAL A1043
 None
 1.31A 4s0vA-5jtvA:
undetectable		 4s0vA-5jtvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 ILE A 494
LEU A 431
LEU A 404
LEU A 516
TYR A 518
 None
 1.24A 4xumA-5jtvA:
undetectable		 4xumA-5jtvA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 LEU A 469
VAL A 485
PHE A 480
LEU A 216
TYR A 243
 None
 1.37A 5i8fA-5jtvA:
undetectable		 5i8fA-5jtvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 ILE A 320
LEU A 228
HIS A 451
VAL A 401
 None
 1.23A 5jmnB-5jtvA:
undetectable		 5jmnB-5jtvA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 8 GLY A 215
LEU A 216
ASN A 226
GLN A 230
PHE A 480
 None
 0.29A 5xu8A-5jtvA:
30.1		 5xu8A-5jtvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 8 LEU A 216
SER A 227
GLN A 230
PHE A 480
 None
 0.63A 5xu8A-5jtvA:
30.1		 5xu8A-5jtvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 ASN A 218
GLY A 458
HIS A 464
ASP A 481
 None
 0.66A 6gh9A-5jtvA:
26.3		 6gh9A-5jtvA:
8.81