SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jtw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 ALA B1067
VAL B1123
TRP B1077
 None
 0.86A 1micA-5jtwB:
undetectable
1micB-5jtwB:
undetectable		 1micA-5jtwB:
3.06
1micB-5jtwB:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 VAL B1329
VAL B1380
LEU B 944
LEU B1331
 None
 0.77A 1pthA-5jtwB:
undetectable		 1pthA-5jtwB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 VAL B1329
VAL B1380
LEU B 944
LEU B1331
 None
 0.76A 1pthB-5jtwB:
undetectable		 1pthB-5jtwB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.11A 2igtA-5jtwB:
undetectable		 2igtA-5jtwB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.11A 2igtB-5jtwB:
undetectable		 2igtB-5jtwB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.13A 2igtC-5jtwB:
undetectable		 2igtC-5jtwB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ARG B1026
ILE B1307
ILE B1195
ALA B1199
THR B1203
 None
 1.14A 2j0dA-5jtwB:
undetectable		 2j0dA-5jtwB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 VAL B 854
VAL B 927
ASP B 925
VAL B 913
 None
 1.02A 2qbnA-5jtwB:
undetectable		 2qbnA-5jtwB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 LEU B1088
LEU B1022
ALA B1148
VAL B1306
LEU B1132
 None
 1.22A 3b0wA-5jtwB:
undetectable		 3b0wA-5jtwB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 LYS B1030
LEU B1312
ASP B1310
SER B1286
 None
 1.09A 3dzgA-5jtwB:
undetectable		 3dzgA-5jtwB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 5 ASP B1029
ILE B1049
VAL B1085
THR B1305
 None
 1.08A 3eigA-5jtwB:
undetectable		 3eigA-5jtwB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 LEU B 931
VAL B 869
VAL B 872
PHE B 899
LEU B 851
 None
 1.11A 3medA-5jtwB:
undetectable
3medB-5jtwB:
undetectable		 3medA-5jtwB:
22.03
3medB-5jtwB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 5 SER B 893
ARG B 895
PRO B 896
VAL B 854
 None
 1.05A 3sufC-5jtwB:
undetectable		 3sufC-5jtwB:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 5 SER B 842
ASP B 973
ASP B 971
ILE B 969
 None
 1.39A 3uj7B-5jtwB:
undetectable		 3uj7B-5jtwB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 4 ILE B 772
VAL B 927
VAL B 914
ARG B 916
 None
 0.67A 4m6tA-5jtwB:
undetectable		 4m6tA-5jtwB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 THR B1305
ALA B1019
PHE B1144
LEU B1018
VAL B1085
 None
 1.18A 5hw4A-5jtwB:
undetectable		 5hw4A-5jtwB:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 THR B1305
ALA B1019
PHE B1144
LEU B1018
VAL B1085
 None
 1.21A 5hw4C-5jtwB:
undetectable		 5hw4C-5jtwB:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 LEU B1141
THR B1203
ALA B1199
ILE B1195
ILE B1147
 None
 1.07A 5mioB-5jtwB:
undetectable		 5mioB-5jtwB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 4 LEU B1270
LEU B1273
SER B1313
ALA B1318
 None
 1.10A 5uunA-5jtwB:
4.2		 5uunA-5jtwB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5jtw COMPLEMENT C4-A
(Homo
sapiens) 		4 / 4 LEU B1273
LEU B1270
SER B1286
ALA B1266
 None
 1.09A 5uunA-5jtwB:
4.2		 5uunA-5jtwB:
17.53