SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5juf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		5 / 12 GLY A   8
LEU A   3
ILE A  72
ILE A  55
LEU A  52
 None
 1.23A 1kyvA-5jufA:
undetectable
1kyvE-5jufA:
undetectable		 1kyvA-5jufA:
22.96
1kyvE-5jufA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		5 / 12 ILE A  55
LEU A  52
GLY A   8
LEU A   3
ILE A  72
 None
 1.23A 1kyvB-5jufA:
undetectable
1kyvC-5jufA:
undetectable		 1kyvB-5jufA:
22.96
1kyvC-5jufA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		5 / 12 ILE A  55
LEU A  52
GLY A   8
LEU A   3
ILE A  72
 None
 1.23A 1kyvC-5jufA:
undetectable
1kyvD-5jufA:
undetectable		 1kyvC-5jufA:
22.96
1kyvD-5jufA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 6 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 0.99A 1mt1A-5jufA:
undetectable
1mt1F-5jufA:
undetectable		 1mt1A-5jufA:
9.35
1mt1F-5jufA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 6 ILE A 187
LEU A 210
ASP A 209
LEU A 163
 None
 1.01A 1mt1B-5jufA:
undetectable
1mt1C-5jufA:
undetectable		 1mt1B-5jufA:
13.87
1mt1C-5jufA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 0.97A 1n13I-5jufA:
undetectable
1n13L-5jufA:
undetectable		 1n13I-5jufA:
9.35
1n13L-5jufA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 PHE A 158
VAL A 165
ASP A 162
ILE A 166
 None
 0.99A 1p7rA-5jufA:
undetectable		 1p7rA-5jufA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 8 LYS A  42
GLU A  44
ILE A  38
GLU A 143
 None
 0.96A 2j9dJ-5jufA:
undetectable
2j9dK-5jufA:
undetectable
2j9dL-5jufA:
undetectable		 2j9dJ-5jufA:
18.69
2j9dK-5jufA:
18.69
2j9dL-5jufA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 ILE A 187
LEU A 210
ASP A 209
LEU A 163
 None
 0.98A 2qqcB-5jufA:
undetectable
2qqcC-5jufA:
undetectable		 2qqcB-5jufA:
13.55
2qqcC-5jufA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 0.98A 2qqcA-5jufA:
undetectable
2qqcF-5jufA:
undetectable		 2qqcA-5jufA:
9.35
2qqcF-5jufA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 1.00A 2qqcG-5jufA:
undetectable
2qqcJ-5jufA:
undetectable		 2qqcG-5jufA:
9.35
2qqcJ-5jufA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 0.99A 2qqcI-5jufA:
undetectable
2qqcL-5jufA:
undetectable		 2qqcI-5jufA:
9.35
2qqcL-5jufA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 1.07A 2qqdA-5jufA:
undetectable
2qqdE-5jufA:
undetectable		 2qqdA-5jufA:
9.35
2qqdE-5jufA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		3 / 3 GLU A  23
GLN A  36
ARG A  39
 None
 0.79A 2w3bB-5jufA:
undetectable		 2w3bB-5jufA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 8 ILE A  74
VAL A 107
SER A  45
TYR A  78
 None
 0.93A 2yoeB-5jufA:
1.9
2yoeC-5jufA:
5.1		 2yoeB-5jufA:
22.85
2yoeC-5jufA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 6 GLU A 142
PHE A 149
TYR A 169
HIS A 172
 None
 1.03A 4uciA-5jufA:
undetectable		 4uciA-5jufA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 7 GLU A 142
PHE A 149
TYR A 169
HIS A 172
 None
 0.98A 4uciB-5jufA:
undetectable		 4uciB-5jufA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5juf TRANSCRIPTIONAL
REGULATOR
(Streptococcus
thermophilus) 		4 / 6 ARG A  84
GLU A  80
GLU A 106
VAL A 107
 None
 1.13A 5h4dA-5jufA:
undetectable		 5h4dA-5jufA:
22.67