SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jvb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 7 GLU A  40
GLU A  36
LEU A  49
GLU A  48
 None
 1.14A 1linA-5jvbA:
undetectable		 1linA-5jvbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 9 VAL A 163
LEU A 177
VAL A 104
GLY A 106
ALA A 174
 None
 1.15A 1pxxB-5jvbA:
undetectable		 1pxxB-5jvbA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.19A 1pxxC-5jvbA:
undetectable		 1pxxC-5jvbA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 10 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.19A 1pxxD-5jvbA:
undetectable		 1pxxD-5jvbA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 LEU A  49
ASN A  32
PHE A 240
GLU A  40
LEU A  39
 None
 1.30A 2bxfB-5jvbA:
undetectable		 2bxfB-5jvbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 10 ALA A 227
LEU A 216
LEU A 220
LEU A  43
ARG A 213
 None
 1.40A 2ceoB-5jvbA:
undetectable		 2ceoB-5jvbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 8 LEU A 185
SER A 132
VAL A 157
GLY A 158
 None
2PO  A 301 (-2.5A)
None
None
 0.93A 2qd5B-5jvbA:
3.8		 2qd5B-5jvbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 11 ASP A  54
LEU A  20
ASP A 127
ILE A  59
SER A  56
 None
 1.41A 3o94B-5jvbA:
undetectable		 3o94B-5jvbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 LEU A 185
TYR A  55
VAL A 157
GLY A 126
LEU A 177
 None
2PO  A 301 (-4.5A)
None
None
None
 1.27A 3pghA-5jvbA:
undetectable		 3pghA-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 11 VAL A 163
LEU A 177
TYR A 125
GLY A 106
ALA A 174
 None
 1.15A 3pghB-5jvbA:
undetectable		 3pghB-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 11 VAL A 163
LEU A 177
VAL A 104
GLY A 106
ALA A 174
 None
 1.16A 3pghB-5jvbA:
undetectable		 3pghB-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.32A 4coxC-5jvbA:
undetectable		 4coxC-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 9 ALA A 166
ILE A 105
GLY A 106
ILE A 112
VAL A 157
 None
 1.11A 4nptA-5jvbA:
undetectable		 4nptA-5jvbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.29A 4otyA-5jvbA:
undetectable		 4otyA-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.28A 4otyB-5jvbA:
undetectable		 4otyB-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 GLY A 170
GLU A 109
ILE A 122
ALA A 124
VAL A 155
 None
 0.98A 4u8yB-5jvbA:
undetectable		 4u8yB-5jvbA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 GLY A 170
GLU A 109
ILE A 122
ALA A 124
VAL A 155
 None
 1.01A 4u95B-5jvbA:
undetectable		 4u95B-5jvbA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.27A 5ikqA-5jvbA:
undetectable		 5ikqA-5jvbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
 None
 1.30A 5ikqB-5jvbA:
undetectable		 5ikqB-5jvbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 LEU A 185
TYR A  55
VAL A 157
GLY A 126
SER A 133
LEU A 177
 None
2PO  A 301 (-4.5A)
None
None
2PO  A 301 ( 4.4A)
None
 1.29A 5jvzA-5jvbA:
undetectable		 5jvzA-5jvbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 LEU A 185
TYR A  55
GLY A 126
SER A 133
LEU A 177
 None
2PO  A 301 (-4.5A)
None
2PO  A 301 ( 4.4A)
None
 1.04A 5jvzB-5jvbA:
undetectable		 5jvzB-5jvbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 7 GLY A 158
PHE A 156
SER A 133
ASP A 127
 None
None
2PO  A 301 ( 4.4A)
None
 1.00A 5n5dB-5jvbA:
2.4		 5n5dB-5jvbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 8 PRO A 137
THR A 131
TYR A 125
PRO A 180
 None
2PO  A 301 (-3.6A)
None
None
 1.21A 5x2sI-5jvbA:
undetectable
5x2sJ-5jvbA:
undetectable
5x2sK-5jvbA:
undetectable		 5x2sI-5jvbA:
19.86
5x2sJ-5jvbA:
23.48
5x2sK-5jvbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 5 TYR A 100
GLN A 207
GLY A 260
ILE A 136
 None
 1.44A 6debB-5jvbA:
undetectable		 6debB-5jvbA:
15.07