SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  47
LEU A  49
THR A 128
VAL A 126
 None
 0.92A 1dvxB-5jvfA:
undetectable		 1dvxB-5jvfA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 MET A  99
PHE A 139
ALA A  67
ILE A  70
 None
None
IOD  A 304 ( 4.2A)
None
 1.06A 1fxhA-5jvfA:
undetectable
1fxhB-5jvfA:
undetectable		 1fxhA-5jvfA:
23.00
1fxhB-5jvfA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 260
LEU A 121
ASN A 120
VAL A  10
 None
None
None
IOD  A 302 (-4.5A)
 1.38A 1lqtA-5jvfA:
2.2		 1lqtA-5jvfA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 260
LEU A 121
ASN A 120
VAL A  10
 None
None
None
IOD  A 302 (-4.5A)
 1.38A 1lqtB-5jvfA:
3.3		 1lqtB-5jvfA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 260
LEU A 121
ASN A 120
VAL A  10
 None
None
None
IOD  A 302 (-4.5A)
 1.38A 1lquA-5jvfA:
3.3		 1lquA-5jvfA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 260
LEU A 121
ASN A 120
VAL A  10
 None
None
None
IOD  A 302 (-4.5A)
 1.37A 1lquB-5jvfA:
2.6		 1lquB-5jvfA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 163
LEU A 167
VAL A 136
ALA A 143
ALA A 142
 None
 1.15A 1n5xA-5jvfA:
undetectable		 1n5xA-5jvfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 163
LEU A 167
VAL A 136
ALA A 143
ALA A 142
 None
 1.14A 1n5xB-5jvfA:
undetectable		 1n5xB-5jvfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 117
ARG A 260
ARG A  40
ILE A  13
PHE A 114
 None
 1.42A 1y0xX-5jvfA:
undetectable		 1y0xX-5jvfA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  44
ASP A  46
PRO A  84
ILE A  89
 None
 1.00A 2aofB-5jvfA:
undetectable		 2aofB-5jvfA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  79
PHE A 114
PHE A 266
LEU A 124
ALA A  47
 None
 1.28A 3apvA-5jvfA:
undetectable		 3apvA-5jvfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 146
PHE A 266
PHE A 114
LEU A 270
ALA A  47
 None
 1.47A 3apvA-5jvfA:
undetectable		 3apvA-5jvfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  79
PHE A 114
PHE A 266
LEU A 124
ALA A  47
 None
 1.26A 3apvB-5jvfA:
undetectable		 3apvB-5jvfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  79
PHE A 114
PHE A 266
LEU A 124
ALA A  47
 None
 1.28A 3apwB-5jvfA:
undetectable		 3apwB-5jvfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 149
ASP A 127
ILE A 214
ASN A 181
 None
None
None
IOD  A 311 (-4.3A)
 1.03A 3avpA-5jvfA:
undetectable		 3avpA-5jvfA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A  47
LEU A  49
THR A 128
VAL A 126
 None
 0.98A 3d2tB-5jvfA:
undetectable		 3d2tB-5jvfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 267
LEU A 270
ILE A  70
ALA A 113
 None
 0.95A 3n8yB-5jvfA:
undetectable		 3n8yB-5jvfA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  47
LEU A  49
THR A 128
VAL A 126
 None
 0.89A 3ozkB-5jvfA:
undetectable		 3ozkB-5jvfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 263
ASN A 258
ARG A 260
PHE A 265
 IOD  A 302 (-4.9A)
IOD  A 302 ( 4.9A)
None
None
 0.79A 4m5mA-5jvfA:
undetectable		 4m5mA-5jvfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5jvf SITE-DETERMINING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 SER A  28
THR A 128
GLY A  17
GLY A  18
 None
None
None
IOD  A 311 (-3.5A)
 0.72A 4yjiA-5jvfA:
undetectable		 4yjiA-5jvfA:
20.44