SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		3 / 3 ASN A  88
ALA A 110
ASN A 112
 None
 0.79A 1n4fA-5jw6A:
undetectable		 1n4fA-5jw6A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		5 / 10 ALA A  51
LEU A  34
LEU A  67
SER A  43
LEU A  69
 SO4  A 402 ( 4.4A)
None
None
SO4  A 402 (-2.8A)
None
 1.22A 2ceoB-5jw6A:
undetectable		 2ceoB-5jw6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 7 MET A 252
VAL A 255
PHE A 335
ARG A 321
 None
 1.10A 2kotA-5jw6A:
undetectable		 2kotA-5jw6A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 7 VAL A 156
ILE A 344
GLY A 314
ARG A 309
 None
 0.82A 3bjwB-5jw6A:
undetectable		 3bjwB-5jw6A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 7 VAL A 156
ILE A 344
GLY A 314
ARG A 309
 None
 0.78A 3bjwF-5jw6A:
undetectable		 3bjwF-5jw6A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 7 VAL A 156
ILE A 344
GLY A 314
ARG A 309
 None
 0.83A 3bjwH-5jw6A:
undetectable		 3bjwH-5jw6A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 4 SER A  17
GLY A  16
GLY A 186
GLY A 188
 SO4  A 403 (-2.8A)
None
SO4  A 403 (-3.8A)
SO4  A 403 (-3.9A)
 0.92A 3bogB-5jw6A:
undetectable
3bogD-5jw6A:
undetectable		 3bogB-5jw6A:
undetectable
3bogD-5jw6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		5 / 11 VAL A 296
GLU A 268
LEU A 166
PHE A 259
PHE A 170
 None
 1.25A 3tbgA-5jw6A:
undetectable		 3tbgA-5jw6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 4 PRO A 172
LEU A 220
HIS A 130
LEU A 133
 None
 1.37A 3vw7A-5jw6A:
undetectable		 3vw7A-5jw6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		3 / 3 SER A 194
MET A 198
ASP A 249
 None
 0.97A 4mm4B-5jw6A:
undetectable		 4mm4B-5jw6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 7 ILE A  95
GLY A  13
THR A  15
LEU A  69
 None
None
SO4  A 402 (-3.2A)
None
 0.99A 5esmA-5jw6A:
undetectable		 5esmA-5jw6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		5 / 12 ALA A 347
GLY A 348
SER A 349
GLU A 355
GLU A 280
 None
 1.21A 5nwuA-5jw6A:
undetectable		 5nwuA-5jw6A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		5 / 12 VAL A  11
ALA A  39
TYR A  48
ALA A  14
GLY A  13
 None
SO4  A 402 (-3.1A)
None
None
None
 1.31A 5tzoA-5jw6A:
undetectable		 5tzoA-5jw6A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		5 / 12 VAL A  11
ALA A  39
TYR A  48
ALA A  14
GLY A  13
 None
SO4  A 402 (-3.1A)
None
None
None
 1.30A 5tzoC-5jw6A:
undetectable		 5tzoC-5jw6A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		3 / 3 THR A 180
MET A 252
HIS A 251
 None
 1.00A 5uunA-5jw6A:
undetectable		 5uunA-5jw6A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		4 / 5 ARG A  70
PHE A  22
LEU A  12
LEU A  64
 None
 1.11A 5veuH-5jw6A:
undetectable		 5veuH-5jw6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		5 / 12 VAL A 178
LEU A 212
VAL A 156
GLY A 158
PHE A 163
 None
 1.05A 6a94B-5jw6A:
undetectable		 6a94B-5jw6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Aspergillus
fumigatus) 		3 / 3 ARG A 323
PHE A 297
PHE A 254
 None
 1.00A 6nknC-5jw6A:
undetectable
6nknJ-5jw6A:
undetectable		 6nknC-5jw6A:
19.73
6nknJ-5jw6A:
10.00