SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens;
Salmonella
enterica)
5 / 10 ALA A 341
GLU B  26
ARG A 296
ILE A 324
LEU A 382
None
1.43A 1a52A-5jw7A:
undetectable
1a52A-5jw7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens;
Salmonella
enterica)
5 / 10 ALA A 341
GLU B  26
ARG A 296
ILE A 324
LEU A 382
None
1.46A 1a52B-5jw7A:
undetectable
1a52B-5jw7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 12 LEU A 290
LEU A 273
VAL A 271
SER A 266
PHE A 243
None
1.15A 1eqbA-5jw7A:
undetectable
1eqbA-5jw7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 12 LEU A 290
LEU A 273
VAL A 271
SER A 266
PHE A 243
None
1.16A 1eqbB-5jw7A:
undetectable
1eqbB-5jw7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 12 LEU A 290
LEU A 273
VAL A 271
SER A 266
PHE A 243
None
1.15A 1eqbD-5jw7A:
undetectable
1eqbD-5jw7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
4 / 5 LEU A 326
GLU A 370
ALA A 374
LEU A 331
None
1.12A 1eta2-5jw7A:
undetectable
1eta2-5jw7A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Salmonella
enterica;
Homo
sapiens)
4 / 6 PRO A 334
LEU B  25
HIS A 297
ARG A 296
None
1.40A 1oafA-5jw7A:
undetectable
1oafA-5jw7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.73A 1v54N-5jw7B:
undetectable
1v54W-5jw7B:
undetectable
1v54N-5jw7B:
10.76
1v54W-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.76A 2dyrN-5jw7B:
undetectable
2dyrW-5jw7B:
undetectable
2dyrN-5jw7B:
10.76
2dyrW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.75A 2eijN-5jw7B:
undetectable
2eijW-5jw7B:
undetectable
2eijN-5jw7B:
10.76
2eijW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.80A 2eikN-5jw7B:
undetectable
2eikW-5jw7B:
undetectable
2eikN-5jw7B:
10.76
2eikW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.77A 2eilN-5jw7B:
undetectable
2eilW-5jw7B:
undetectable
2eilN-5jw7B:
10.76
2eilW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
4 / 7 SER A 231
ALA A 200
SER A 198
ASN A 227
None
1.05A 2i91A-5jw7A:
undetectable
2i91A-5jw7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
4 / 7 SER A 231
ALA A 200
SER A 198
ASN A 227
None
1.05A 2i91B-5jw7A:
3.3
2i91B-5jw7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
4 / 8 SER A 264
ILE A 286
HIS A 242
ASP A 244
None
1.12A 2xadA-5jw7A:
undetectable
2xadA-5jw7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.73A 3ablA-5jw7B:
undetectable
3ablJ-5jw7B:
undetectable
3ablA-5jw7B:
10.76
3ablJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.69A 3ablN-5jw7B:
undetectable
3ablW-5jw7B:
undetectable
3ablN-5jw7B:
10.76
3ablW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.73A 3ag3N-5jw7B:
undetectable
3ag3W-5jw7B:
undetectable
3ag3N-5jw7B:
10.76
3ag3W-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 12 GLN A 282
PHE A 345
THR A 359
ASN A 351
GLY A 353
None
1.45A 3aodC-5jw7A:
undetectable
3aodC-5jw7A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.77A 3asnN-5jw7B:
undetectable
3asnW-5jw7B:
undetectable
3asnN-5jw7B:
10.76
3asnW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
4 / 8 MET A 333
ILE A 360
PRO A 314
TRP A 330
None
1.30A 4f4dB-5jw7A:
undetectable
4f4dB-5jw7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 9 LEU A 346
LEU A 331
THR A 359
LEU A 357
ILE A 360
None
1.21A 4ubsA-5jw7A:
2.2
4ubsA-5jw7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.69A 5b1bA-5jw7B:
undetectable
5b1bJ-5jw7B:
undetectable
5b1bA-5jw7B:
10.76
5b1bJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 10 GLY A 327
LEU A 306
ASN A 269
LEU A 290
LEU A 301
None
1.31A 5fhzC-5jw7A:
undetectable
5fhzC-5jw7A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
4 / 6 VAL A 395
LEU A 399
CYH A 391
LEU A 387
None
1.21A 5hrqB-5jw7A:
undetectable
5hrqI-5jw7A:
undetectable
5hrqJ-5jw7A:
undetectable
5hrqB-5jw7A:
8.45
5hrqI-5jw7A:
4.49
5hrqJ-5jw7A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 12 LEU A 253
PHE A 248
PHE A 233
THR A 261
LEU A 211
None
1.15A 5iepA-5jw7A:
undetectable
5iepA-5jw7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.68A 5iy5A-5jw7B:
undetectable
5iy5J-5jw7B:
undetectable
5iy5A-5jw7B:
10.76
5iy5J-5jw7B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Salmonella
enterica;
Homo
sapiens)
5 / 11 VAL A 317
SER A 318
GLU B  58
PRO A 314
LEU A 294
None
1.49A 5jh7B-5jw7A:
undetectable
5jh7B-5jw7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica)
5 / 12 PHE A 202
ILE A 223
SER A 251
PHE A 207
LEU A 211
None
1.23A 5uanB-5jw7A:
undetectable
5uanB-5jw7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.67A 5xdqA-5jw7B:
undetectable
5xdqJ-5jw7B:
undetectable
5xdqA-5jw7B:
10.76
5xdqJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.72A 5xdxN-5jw7B:
undetectable
5xdxW-5jw7B:
undetectable
5xdxN-5jw7B:
10.76
5xdxW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.68A 5zcoA-5jw7B:
undetectable
5zcoJ-5jw7B:
undetectable
5zcoA-5jw7B:
10.76
5zcoJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 8 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.70A 5zcqN-5jw7B:
undetectable
5zcqW-5jw7B:
undetectable
5zcqN-5jw7B:
10.76
5zcqW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.66A 6nmfA-5jw7B:
undetectable
6nmfJ-5jw7B:
undetectable
6nmfA-5jw7B:
10.76
6nmfJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 7 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.76A 6nmpA-5jw7B:
undetectable
6nmpJ-5jw7B:
undetectable
6nmpA-5jw7B:
10.76
6nmpJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo
sapiens)
4 / 5 ILE B  23
LEU B  48
THR B  33
LEU B  34
None
0.73A 6nmpN-5jw7B:
undetectable
6nmpW-5jw7B:
undetectable
6nmpN-5jw7B:
10.76
6nmpW-5jw7B:
18.68