SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		3 / 3 THR A 394
THR A 392
PRO A 396
 None
 0.83A 1a7yB-5jwbA:
undetectable		 1a7yB-5jwbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 9 LEU A 305
VAL A 205
GLY A 207
ALA A 308
SER A 309
 None
None
NAD  A 608 (-3.3A)
NAD  A 608 ( 4.9A)
NAD  A 608 (-4.7A)
 1.21A 1pxxB-5jwbA:
undetectable		 1pxxB-5jwbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 10 LEU A 305
VAL A 205
GLY A 207
ALA A 308
SER A 309
 None
None
NAD  A 608 (-3.3A)
NAD  A 608 ( 4.9A)
NAD  A 608 (-4.7A)
 1.21A 1pxxD-5jwbA:
undetectable		 1pxxD-5jwbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		3 / 3 THR A 394
THR A 392
PRO A 396
 None
 0.79A 1qfiB-5jwbA:
undetectable		 1qfiB-5jwbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 11 PHE A 531
ILE A 223
PHE A 222
ILE A 234
PHE A 180
 None
ACT  A 610 ( 4.5A)
None
None
None
 1.16A 2dg4A-5jwbA:
undetectable		 2dg4A-5jwbA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 7 GLY A 207
GLY A 208
VAL A 278
SER A 309
 NAD  A 608 (-3.3A)
NAD  A 608 ( 4.8A)
NAD  A 608 (-4.2A)
NAD  A 608 (-4.7A)
 0.48A 2oa1B-5jwbA:
9.8		 2oa1B-5jwbA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 5 LEU A 181
LEU A 304
CYH A 187
THR A 188
 None
None
None
ACT  A 611 ( 4.4A)
 1.30A 2oaxD-5jwbA:
undetectable		 2oaxD-5jwbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 7 PHE A 465
PRO A 432
THR A 433
TRP A 469
 None
 1.37A 2q6kA-5jwbA:
undetectable		 2q6kA-5jwbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 6 PHE A 465
PRO A 432
THR A 433
TRP A 469
 None
 1.37A 2q6oB-5jwbA:
undetectable		 2q6oB-5jwbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 12 ILE A 344
ILE A 317
LEU A 333
CYH A 355
LEU A 144
 None
None
None
MG  A 602 (-3.2A)
None
 1.18A 2qo5A-5jwbA:
undetectable		 2qo5A-5jwbA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 8 ASN A  92
SER A 513
PHE A 101
ASN A 100
 None
 1.11A 2wekA-5jwbA:
2.1		 2wekA-5jwbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 8 ASN A  92
SER A 513
PHE A 101
ASN A 100
 None
 1.13A 2wekB-5jwbA:
2.5		 2wekB-5jwbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 6 ILE A 317
ILE A  44
TYR A 141
LEU A 321
 None
 1.00A 3adsA-5jwbA:
undetectable		 3adsA-5jwbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 12 GLY A  49
GLY A 353
GLY A 149
LEU A 311
ALA A 439
 FAD  A 601 (-3.1A)
FAD  A 601 ( 3.3A)
MG  A 602 (-3.2A)
None
FAD  A 601 (-3.6A)
 1.06A 3kkzB-5jwbA:
2.7		 3kkzB-5jwbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 7 LEU A 139
LEU A 115
CYH A 129
ASN A 128
 None
 0.97A 3lm8B-5jwbA:
undetectable
3lm8D-5jwbA:
undetectable		 3lm8B-5jwbA:
19.76
3lm8D-5jwbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		3 / 3 GLY A 246
THR A 274
ASN A 248
 None
 0.72A 3v4tD-5jwbA:
undetectable		 3v4tD-5jwbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 6 THR A 435
ASN A 438
GLY A 353
ASP A 354
 FAD  A 601 (-3.6A)
None
FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
 1.24A 3w9tE-5jwbA:
undetectable		 3w9tE-5jwbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 9 ILE A  69
LEU A  46
ILE A 146
ILE A 145
ILE A 349
 None
FAD  A 601 ( 4.4A)
None
None
None
 1.01A 3zosA-5jwbA:
undetectable		 3zosA-5jwbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 6 ILE A 454
VAL A 449
LYS A 338
LEU A 446
 None
 1.11A 4em2A-5jwbA:
undetectable		 4em2A-5jwbA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 8 ASP A 336
ASP A 426
GLU A 337
GLU A 365
 None
 1.12A 4gkhC-5jwbA:
undetectable
4gkhK-5jwbA:
undetectable		 4gkhC-5jwbA:
19.13
4gkhK-5jwbA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		3 / 3 VAL A 481
SER A 497
TRP A 500
 None
CXS  A 614 ( 4.8A)
CXS  A 614 (-3.8A)
 0.12A 5jwaA-5jwbA:
56.9		 5jwaA-5jwbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JWA_A_ACTA610_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 4 ASP A 221
LYS A 225
HIS A 479
ARG A 529
 CXS  A 614 (-3.7A)
CXS  A 614 (-2.4A)
CXS  A 614 (-3.6A)
CXS  A 614 (-2.3A)
 0.47A 5jwaA-5jwbA:
56.9		 5jwaA-5jwbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JWA_A_ACTA613_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 4 ASP A 520
LYS A 523
THR A 524
PRO A 530
 ACT  A 612 (-3.3A)
ACT  A 612 (-3.7A)
ACT  A 612 (-4.5A)
None
 0.21A 5jwaA-5jwbA:
56.9		 5jwaA-5jwbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JWA_H_ACTH610_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		4 / 4 ASP A 221
LYS A 225
HIS A 479
ARG A 529
 CXS  A 614 (-3.7A)
CXS  A 614 (-2.4A)
CXS  A 614 (-3.6A)
CXS  A 614 (-2.3A)
 0.57A 5jwaH-5jwbA:
56.9		 5jwaH-5jwbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		6 / 6 ILE A 157
VAL A 206
TYR A 277
VAL A 278
TRP A 307
SER A 309
 None
NAD  A 608 (-4.8A)
None
NAD  A 608 (-4.2A)
None
NAD  A 608 (-4.7A)
 1.46A 5jwaH-5jwbA:
56.9		 5jwaH-5jwbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		3 / 3 SER A 241
SER A 239
PHE A 286
 None
 0.90A 5mugA-5jwbA:
undetectable		 5mugA-5jwbA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 12 LEU A 268
VAL A 272
GLY A 212
LEU A 273
ILE A 270
 None
 1.06A 6dgxB-5jwbA:
undetectable		 6dgxB-5jwbA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 12 LEU A 268
VAL A 272
GLY A 212
LEU A 273
ILE A 270
 None
 1.07A 6dh6B-5jwbA:
undetectable		 6dh6B-5jwbA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE
(Plasmodium
falciparum) 		5 / 12 VAL A 203
ILE A 306
GLY A 212
LEU A 304
ILE A 240
 None
 1.05A 6dh6B-5jwbA:
undetectable		 6dh6B-5jwbA:
11.40