SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 GLY A 454
SER A 447
LEU A 436
LEU A 445
HIS A 457
 None
 1.25A 1a8uA-5jwzA:
undetectable		 1a8uA-5jwzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 GLY A 454
SER A 447
LEU A 436
LEU A 445
HIS A 457
 None
 1.22A 1a8uB-5jwzA:
undetectable		 1a8uB-5jwzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 ALA A  15
VAL A 463
TRP A 363
 None
 0.91A 1c4dC-5jwzA:
undetectable
1c4dD-5jwzA:
undetectable		 1c4dC-5jwzA:
2.12
1c4dD-5jwzA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 TRP A 363
ALA A  15
VAL A 463
 None
 0.93A 1c4dC-5jwzA:
undetectable
1c4dD-5jwzA:
undetectable		 1c4dC-5jwzA:
2.12
1c4dD-5jwzA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 TRP A  64
VAL A  62
TRP A  67
 None
 1.06A 1gmkC-5jwzA:
undetectable
1gmkD-5jwzA:
undetectable		 1gmkC-5jwzA:
2.12
1gmkD-5jwzA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 9 GLY A 132
PRO A  24
GLY A 130
GLY A 123
GLY A 124
 None
 1.14A 1mxdA-5jwzA:
undetectable		 1mxdA-5jwzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 4 GLY A  71
VAL A  73
TRP A  69
GLY A 101
 None
 1.17A 1ng8A-5jwzA:
undetectable		 1ng8A-5jwzA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 4 GLY A  71
VAL A  73
TRP A  69
GLY A 101
 None
 1.18A 1ng8B-5jwzA:
undetectable		 1ng8B-5jwzA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.38A 1rqpA-5jwzA:
undetectable		 1rqpA-5jwzA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.37A 1rqpB-5jwzA:
undetectable		 1rqpB-5jwzA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.38A 1rqpC-5jwzA:
undetectable		 1rqpC-5jwzA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 4 GLY A 454
SER A 447
ILE A  17
HIS A 457
 None
 1.15A 1yajJ-5jwzA:
undetectable		 1yajJ-5jwzA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 7 GLY A 274
SER A 302
SER A 320
GLU A 384
 None
 1.00A 2c8aB-5jwzA:
undetectable		 2c8aB-5jwzA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 7 GLY A 274
SER A 302
SER A 320
GLU A 384
 None
 1.03A 2c8aD-5jwzA:
undetectable		 2c8aD-5jwzA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 7 SER A  51
ASP A  49
ARG A 109
GLU A  32
 None
 1.02A 2cdqB-5jwzA:
undetectable		 2cdqB-5jwzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 GLY A  25
GLY A 130
GLU A 387
ILE A 428
VAL A 404
 None
 1.01A 2oxtC-5jwzA:
undetectable		 2oxtC-5jwzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 8 PRO A 150
SER A 151
VAL A  73
GLY A 124
 None
 1.14A 2qd3A-5jwzA:
undetectable		 2qd3A-5jwzA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 9 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.40A 2v7uC-5jwzA:
0.0		 2v7uC-5jwzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 9 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.40A 2v7uA-5jwzA:
0.0		 2v7uA-5jwzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1300_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 9 ASP A 296
ASP A 288
SER A 290
TYR A 298
PHE A 301
 None
 1.40A 2v7uB-5jwzA:
0.0		 2v7uB-5jwzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 MET A 382
GLU A 430
ASN A 722
 None
 1.10A 3a27A-5jwzA:
undetectable		 3a27A-5jwzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 GLU A 567
SER A 538
VAL A 544
 CA  A 803 ( 4.4A)
None
None
 0.84A 3eeoA-5jwzA:
undetectable		 3eeoA-5jwzA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 5 PRO A 291
VAL A 292
THR A 265
GLY A 271
 None
 1.11A 3elzB-5jwzA:
undetectable		 3elzB-5jwzA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 GLY A 493
TRP A 537
VAL A 526
 None
 0.74A 3n62B-5jwzA:
undetectable		 3n62B-5jwzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 GLY A 493
TRP A 537
VAL A 526
 None
 0.76A 3n65B-5jwzA:
undetectable		 3n65B-5jwzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 GLY A 493
TRP A 537
VAL A 526
 None
 0.74A 3n66B-5jwzA:
undetectable		 3n66B-5jwzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 TYR A 319
GLY A 300
SER A 263
THR A 261
 None
 0.93A 3tj7A-5jwzA:
undetectable
3tj7B-5jwzA:
undetectable		 3tj7A-5jwzA:
12.29
3tj7B-5jwzA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 TYR A 319
GLY A 300
SER A 263
THR A 261
 None
 0.93A 3tj7C-5jwzA:
undetectable
3tj7D-5jwzA:
undetectable		 3tj7C-5jwzA:
12.29
3tj7D-5jwzA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 SER A 263
THR A 261
TYR A 319
GLY A 300
 None
 0.95A 3tj7C-5jwzA:
undetectable
3tj7D-5jwzA:
undetectable		 3tj7C-5jwzA:
12.29
3tj7D-5jwzA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 LEU A 364
ILE A  17
GLY A  21
ILE A 452
ARG A 724
 None
 1.03A 3uj6A-5jwzA:
undetectable		 3uj6A-5jwzA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 9 ILE A  17
GLY A  19
VAL A 433
THR A 431
GLN A 727
 None
 1.34A 4acaB-5jwzA:
undetectable
4acaC-5jwzA:
undetectable		 4acaB-5jwzA:
21.95
4acaC-5jwzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 ALA A 509
ALA A 443
PRO A 444
THR A 458
 None
 1.05A 4dtzB-5jwzA:
undetectable		 4dtzB-5jwzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.03A 4e47A-5jwzA:
undetectable		 4e47A-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.03A 4e47B-5jwzA:
undetectable		 4e47B-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.01A 4e47C-5jwzA:
undetectable		 4e47C-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 PHE A 681
ASP A 652
ARG A 678
 None
 0.87A 4eahF-5jwzA:
undetectable		 4eahF-5jwzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 PHE A 681
ASP A 652
ARG A 678
 None
 0.87A 4eahG-5jwzA:
undetectable		 4eahG-5jwzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 SER A  77
ASP A  78
ASP A  83
GLU A  32
 None
 1.06A 4eysA-5jwzA:
undetectable		 4eysA-5jwzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 GLY A 193
PRO A 150
ASN A 191
GLY A 123
 None
 0.82A 4fjpA-5jwzA:
undetectable		 4fjpA-5jwzA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 9 GLY A 128
GLY A 130
ARG A 129
PHE A  22
GLY A 266
 None
 1.42A 4h2gA-5jwzA:
undetectable		 4h2gA-5jwzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.05A 4jdsA-5jwzA:
undetectable		 4jdsA-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.05A 4jdsB-5jwzA:
undetectable		 4jdsB-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.03A 4jdsC-5jwzA:
undetectable		 4jdsC-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 ALA A 542
GLY A 541
GLY A 493
ASN A 494
TRP A 537
 None
 1.13A 4jlgA-5jwzA:
undetectable		 4jlgA-5jwzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 8 LEU A 258
VAL A 306
TRP A 196
LEU A 260
 None
 0.83A 4pwdC-5jwzA:
undetectable		 4pwdC-5jwzA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 10 THR A 281
GLU A 201
ASP A 212
ASP A 200
GLY A 256
 None
 1.47A 4qb9A-5jwzA:
undetectable		 4qb9A-5jwzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 GLU A 429
ILE A 452
THR A 431
HIS A 457
 None
 1.24A 4qwpA-5jwzA:
undetectable		 4qwpA-5jwzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 7 SER A 106
ASP A  60
ARG A 724
GLY A  44
 None
 1.06A 5btfA-5jwzA:
undetectable
5btfC-5jwzA:
undetectable
5btfD-5jwzA:
undetectable		 5btfA-5jwzA:
22.45
5btfC-5jwzA:
22.45
5btfD-5jwzA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 GLY A 523
LEU A 473
SER A 475
ILE A 501
VAL A 520
 None
 1.03A 5dpdA-5jwzA:
undetectable		 5dpdA-5jwzA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 GLY A 523
LEU A 473
SER A 475
ILE A 501
VAL A 520
 None
 1.12A 5dpdB-5jwzA:
undetectable		 5dpdB-5jwzA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 8 VAL A 654
ALA A 622
GLY A 631
SER A 645
 None
 0.78A 5e26C-5jwzA:
undetectable
5e26D-5jwzA:
undetectable		 5e26C-5jwzA:
19.54
5e26D-5jwzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 ARG A  16
ASN A  14
THR A  40
GLY A 723
THR A 431
 None
 1.40A 5oj0A-5jwzA:
undetectable		 5oj0A-5jwzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 LEU A  58
LEU A  59
GLY A  44
GLY A  43
LEU A  75
 None
 1.10A 5uc1A-5jwzA:
undetectable		 5uc1A-5jwzA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 LEU A  58
LEU A  59
GLY A  44
GLY A  43
LEU A  75
 None
 1.10A 5uc1B-5jwzA:
undetectable		 5uc1B-5jwzA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 ILE A  17
LEU A 364
VAL A 361
ALA A  38
TYR A  46
 None
 1.14A 5uxdB-5jwzA:
3.0		 5uxdB-5jwzA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		3 / 3 GLY A 493
TRP A 537
VAL A 526
 None
 0.75A 5vuoB-5jwzA:
undetectable		 5vuoB-5jwzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		5 / 12 ALA A 672
LEU A 632
GLY A 687
ALA A 686
LEU A 612
 None
 1.36A 5x23A-5jwzA:
undetectable		 5x23A-5jwzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 5 PRO A 486
GLY A 487
THR A 488
ASN A 507
 None
 1.02A 5x23A-5jwzA:
undetectable		 5x23A-5jwzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 PRO A 486
GLY A 487
THR A 488
ASN A 507
 None
 0.93A 5x24A-5jwzA:
undetectable		 5x24A-5jwzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5jwz CELLULOSE-BINDING
FAMILY II
(Streptomyces
sp.
SirexAA-E) 		4 / 6 PRO A 486
GLY A 487
THR A 488
ASN A 507
 None
 0.80A 5xxiA-5jwzA:
undetectable		 5xxiA-5jwzA:
20.38