SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.24A 1db1A-5jx3A:
undetectable		 1db1A-5jx3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.23A 1rk3A-5jx3A:
undetectable		 1rk3A-5jx3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 11 VAL A 116
VAL A  64
TYR A 156
LEU A 202
ILE A 198
 None
 1.16A 1t6zB-5jx3A:
undetectable		 1t6zB-5jx3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 11 LEU A 110
ILE A  89
ASP A 192
GLY A 179
TYR A 156
 None
 1.21A 1zz1A-5jx3A:
undetectable		 1zz1A-5jx3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		4 / 7 SER A  88
PHE A 189
GLY A 179
ILE A 166
 GOL  A 402 (-3.5A)
None
None
None
 1.00A 2bdmA-5jx3A:
undetectable		 2bdmA-5jx3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.27A 2hc4A-5jx3A:
undetectable		 2hc4A-5jx3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.22A 2zlcA-5jx3A:
undetectable		 2zlcA-5jx3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 ALA A  93
ILE A 217
GLY A 215
ILE A 113
ILE A  89
 None
 0.92A 3nduA-5jx3A:
undetectable		 3nduA-5jx3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 ALA A  93
ILE A 217
GLY A 215
ILE A 113
ILE A  89
 None
 0.93A 3nduD-5jx3A:
undetectable		 3nduD-5jx3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 9 ALA A  93
ILE A 217
GLY A 215
ILE A 113
ILE A  89
 None
 1.01A 3ndwB-5jx3A:
undetectable		 3ndwB-5jx3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 ALA A  93
ILE A 217
GLY A 215
ILE A 113
ILE A  89
 None
 0.90A 3tkgC-5jx3A:
undetectable		 3tkgC-5jx3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.24A 3vt3A-5jx3A:
undetectable		 3vt3A-5jx3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.19A 3vt7A-5jx3A:
undetectable		 3vt7A-5jx3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 12 ALA A  93
ILE A 217
GLY A 215
ILE A 113
ILE A  89
 None
 1.06A 4njvD-5jx3A:
undetectable		 4njvD-5jx3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 8 GLY A  66
TYR A  70
PHE A  79
SER A  88
ASN A 120
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.8A)
GOL  A 402 (-3.5A)
GOL  A 402 (-2.7A)
 0.78A 4wryA-5jx3A:
21.5		 4wryA-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		4 / 8 GLY A  66
TYR A  70
SER A  88
HIS A 181
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.5A)
GOL  A 403 (-3.9A)
 0.85A 4wryA-5jx3A:
21.5		 4wryA-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 8 GLY A  66
TYR A  70
PHE A  79
SER A  88
ASN A 120
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.8A)
GOL  A 402 (-3.5A)
GOL  A 402 (-2.7A)
 0.80A 4wrzA-5jx3A:
21.5		 4wrzA-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		4 / 8 GLY A  66
TYR A  70
SER A  88
HIS A 181
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.5A)
GOL  A 403 (-3.9A)
 0.94A 4wrzA-5jx3A:
21.5		 4wrzA-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		4 / 7 GLY A  66
TYR A  70
PHE A  79
ASN A 120
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.8A)
GOL  A 402 (-2.7A)
 0.87A 4ws0A-5jx3A:
21.7		 4ws0A-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		5 / 8 GLY A  66
TYR A  70
PHE A  79
SER A  88
ASN A 120
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.8A)
GOL  A 402 (-3.5A)
GOL  A 402 (-2.7A)
 0.80A 4ws1A-5jx3A:
21.8		 4ws1A-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		4 / 8 GLY A  66
TYR A  70
SER A  88
HIS A 181
 GOL  A 402 (-3.1A)
GOL  A 402 (-3.6A)
GOL  A 402 (-3.5A)
GOL  A 403 (-3.9A)
 0.85A 4ws1A-5jx3A:
21.8		 4ws1A-5jx3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5jx3 URACIL-DNA
GLYCOSYLASE
(Vaccinia
virus) 		4 / 8 TYR A  15
SER A   3
THR A  12
THR A   5
 None
 1.11A 5jhdE-5jx3A:
undetectable
5jhdG-5jx3A:
undetectable		 5jhdE-5jx3A:
22.61
5jhdG-5jx3A:
18.13