SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
3 / 3 VAL A 400
VAL A 327
TRP A 401
None
NH4  A 516 (-3.6A)
None
0.96A 1bdwA-5jx5A:
undetectable
1bdwB-5jx5A:
undetectable
1bdwA-5jx5A:
5.47
1bdwB-5jx5A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
4 / 5 SER A 423
ASN A 375
ALA A 427
ASP A 409
None
1.36A 1lqtA-5jx5A:
undetectable
1lqtB-5jx5A:
undetectable
1lqtA-5jx5A:
21.48
1lqtB-5jx5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
4 / 5 SER A 423
ASN A 375
ALA A 427
ASP A 409
None
1.35A 1lquA-5jx5A:
undetectable
1lquB-5jx5A:
undetectable
1lquA-5jx5A:
21.48
1lquB-5jx5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 10 GLU A 246
THR A 325
LEU A 297
LEU A 343
TYR A 339
None
1.34A 2ha6A-5jx5A:
undetectable
2ha6A-5jx5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 10 GLU A 246
THR A 325
LEU A 297
LEU A 343
TYR A 339
None
1.36A 2ha6B-5jx5A:
undetectable
2ha6B-5jx5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 11 GLY A 351
SER A 349
ILE A 308
ALA A 291
THR A 325
None
1.14A 2nnhA-5jx5A:
undetectable
2nnhA-5jx5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 12 GLY A 280
GLN A 282
MET A 243
LEU A 199
ILE A 311
None
1.33A 3mneA-5jx5A:
undetectable
3mneA-5jx5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
4 / 7 GLU A 336
GLN A 341
TYR A 339
PRO A 368
None
0.99A 3ugrA-5jx5A:
5.9
3ugrA-5jx5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 9 LEU A 347
ALA A 291
ASP A 290
LEU A 272
ILE A 308
None
None
NH4  A 516 ( 2.7A)
None
None
1.39A 3wsjA-5jx5A:
undetectable
3wsjA-5jx5A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 11 VAL A 183
ILE A 229
SER A 228
MET A 243
LEU A 199
None
None
EDO  A 511 ( 3.9A)
None
None
1.40A 4lhmA-5jx5A:
undetectable
4lhmA-5jx5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 9 ASN A 342
ALA A 301
ILE A 250
GLY A 251
THR A 325
None
None
EDO  A 507 (-3.7A)
EDO  A 507 (-4.2A)
None
1.12A 4nptA-5jx5A:
undetectable
4nptA-5jx5A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
3 / 3 ARG A 185
GLU A 146
TYR A 186
None
0.90A 4r29D-5jx5A:
undetectable
4r29D-5jx5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)
5jx5 GLUCANASE
(Orpinomyces
sp.
Y102)
5 / 9 ILE A 308
ALA A 291
ILE A 250
ILE A 245
LEU A 272
None
None
EDO  A 507 (-3.7A)
None
None
1.08A 5mvmA-5jx5A:
undetectable
5mvmE-5jx5A:
undetectable
5mvmA-5jx5A:
13.88
5mvmE-5jx5A:
13.88