SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.53A 3huoA-5jxaH:
undetectable		 3huoA-5jxaH:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 111
ARG H  66
VAL H  18
PHE H  82
 None
 1.38A 3jx4A-5jxaH:
undetectable
3jx4B-5jxaH:
undetectable		 3jx4A-5jxaH:
20.89
3jx4B-5jxaH:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 PHE H  82
VAL H 111
ARG H  66
VAL H  18
 None
 1.32A 3jx6A-5jxaH:
undetectable
3jx6B-5jxaH:
undetectable		 3jx6A-5jxaH:
20.89
3jx6B-5jxaH:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG H  23
TRP H  76
GLY H  76
 None
 1.00A 4e7cA-5jxaH:
undetectable		 4e7cA-5jxaH:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.30A 4m7kH-5jxaH:
21.1		 4m7kH-5jxaH:
68.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 111
ARG H  66
VAL H  18
PHE H  82
 None
 1.38A 5addA-5jxaH:
undetectable
5addB-5jxaH:
undetectable		 5addA-5jxaH:
20.89
5addB-5jxaH:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jxa VRC03 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 111
ARG H  66
VAL H  18
PHE H  82
 None
 1.37A 5adeA-5jxaH:
undetectable
5adeB-5jxaH:
undetectable		 5adeA-5jxaH:
20.89
5adeB-5jxaH:
20.89