SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5jxb DISKS LARGE HOMOLOG
4,SYNGAP
(Homo
sapiens;
Mus
musculus) 		5 / 12 ILE A 311
ILE A 313
ALA A 344
LEU A 376
ILE A 324
 None
 1.26A 1xzxX-5jxbA:
undetectable		 1xzxX-5jxbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5jxb DISKS LARGE HOMOLOG
4,SYNGAP
(Homo
sapiens;
Mus
musculus) 		5 / 10 ILE A 324
ILE A 356
LEU A 376
ASN A 378
ILE A 374
 None
 1.20A 2nnhB-5jxbA:
undetectable		 2nnhB-5jxbA:
14.19