SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		5 / 12 LEU A  51
VAL A  50
SER A  47
LEU A 132
LEU A 171
 6OU  A 201 (-4.4A)
None
6OU  A 201 (-3.5A)
None
6OU  A 201 (-4.9A)
 1.29A 2hc4A-5jxdA:
undetectable		 2hc4A-5jxdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		5 / 12 LEU A  51
VAL A  50
SER A  47
LEU A 132
LEU A 171
 6OU  A 201 (-4.4A)
None
6OU  A 201 (-3.5A)
None
6OU  A 201 (-4.9A)
 1.33A 2zlcA-5jxdA:
undetectable		 2zlcA-5jxdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		4 / 7 LEU A 132
VAL A 106
LEU A  75
LEU A 182
 None
6OU  A 201 ( 4.9A)
6OU  A 201 ( 4.9A)
None
 0.95A 3g8iA-5jxdA:
undetectable		 3g8iA-5jxdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		5 / 11 LEU A 128
ILE A 198
ILE A 189
LEU A 185
VAL A  57
 None
None
6OU  A 201 ( 4.9A)
None
None
 0.99A 3w67A-5jxdA:
undetectable		 3w67A-5jxdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		5 / 12 LEU A 128
ILE A 198
ILE A 189
LEU A 185
VAL A  57
 None
None
6OU  A 201 ( 4.9A)
None
None
 1.01A 3w68C-5jxdA:
undetectable		 3w68C-5jxdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		3 / 3 ARG A 154
LYS A  73
LYS A  77
 None
 1.26A 4k50A-5jxdA:
undetectable		 4k50A-5jxdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		3 / 3 ARG A 154
LYS A  73
LYS A  77
 None
 1.24A 4k50E-5jxdA:
undetectable		 4k50E-5jxdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		3 / 3 ARG A 154
LYS A  73
LYS A  77
 None
 1.23A 4k50I-5jxdA:
undetectable		 4k50I-5jxdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		4 / 5 SER A 129
ARG A 125
LEU A 168
ASP A 164
 None
 1.38A 4xdtA-5jxdA:
undetectable		 4xdtA-5jxdA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8
(Mus
musculus) 		5 / 12 VAL A  71
LEU A 185
VAL A  57
HIS A 181
LEU A 182
 None
 1.18A 5ubbA-5jxdA:
undetectable		 5ubbA-5jxdA:
25.79