SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 VAL A 174
LEU A 594
ILE A 191
GLY A 193
ALA A 192
None
0.89A 1cqeA-5jxrA:
undetectable
1cqeA-5jxrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 VAL A 174
LEU A 594
ILE A 191
GLY A 193
ALA A 192
None
0.87A 1cqeB-5jxrA:
undetectable
1cqeB-5jxrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 VAL A 174
LEU A 594
ILE A 191
GLY A 193
ALA A 192
None
0.84A 1eqhA-5jxrA:
undetectable
1eqhA-5jxrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 VAL A 174
LEU A 594
ILE A 191
GLY A 193
ALA A 192
None
0.83A 1eqhB-5jxrA:
0.6
1eqhB-5jxrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 THR A 566
ALA A 596
ASP A 593
LEU A 575
ILE A 561
None
1.26A 1errA-5jxrA:
undetectable
1errA-5jxrA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 8 PHE A 560
TYR A 531
ILE A 561
VAL A 509
None
0.68A 1fslB-5jxrA:
undetectable
1fslB-5jxrA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 7 ALA A 171
ILE A 231
ILE A 198
GLU A 202
None
0.92A 1oniD-5jxrA:
undetectable
1oniF-5jxrA:
0.6
1oniD-5jxrA:
10.97
1oniF-5jxrA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
3 / 3 GLU A 165
TRP A 588
LYS A 137
None
1.36A 1qu2A-5jxrA:
undetectable
1qu2A-5jxrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 VAL A 174
LEU A 594
ILE A 191
GLY A 193
ALA A 192
None
0.85A 2aylB-5jxrA:
0.1
2aylB-5jxrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
GLU A 132
GLU A 156
ARG A 136
ARG A 149
None
1.35A 2htqA-5jxrA:
undetectable
2htqA-5jxrA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 6 ARG A 400
GLN A 220
ASN A 337
LEU A 228
None
1.18A 2nyrA-5jxrA:
undetectable
2nyrA-5jxrA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
3 / 3 SER A 516
GLU A 132
ASP A 126
None
0.84A 2zulA-5jxrA:
undetectable
2zulA-5jxrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
3 / 3 LEU A 485
TRP A 428
TYR A 479
None
1.00A 3aicG-5jxrA:
undetectable
3aicG-5jxrA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 8 LYS A 491
ARG A 141
GLN A 425
GLU A 621
None
1.10A 3dh0A-5jxrA:
2.1
3dh0A-5jxrA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 THR A 221
THR A 218
GLU A 253
ILE A 290
LEU A 197
None
1.48A 3gwxB-5jxrA:
undetectable
3gwxB-5jxrA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
3 / 3 GLU A 474
ASP A 482
ASP A 524
None
0.67A 3jb2A-5jxrA:
undetectable
3jb2A-5jxrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.41A 3k37A-5jxrA:
undetectable
3k37A-5jxrA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.39A 3k39A-5jxrA:
undetectable
3k39A-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.39A 3k39C-5jxrA:
undetectable
3k39C-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
ARG A 136
ARG A 149
None
1.50A 3k39D-5jxrA:
undetectable
3k39D-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.40A 3k39D-5jxrA:
undetectable
3k39D-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.38A 3k39E-5jxrA:
undetectable
3k39E-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.41A 3k39F-5jxrA:
undetectable
3k39F-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.38A 3k39G-5jxrA:
undetectable
3k39G-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.41A 3k39H-5jxrA:
undetectable
3k39H-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.38A 3k39I-5jxrA:
undetectable
3k39I-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.39A 3k39J-5jxrA:
undetectable
3k39J-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.41A 3k39K-5jxrA:
undetectable
3k39K-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.38A 3k39L-5jxrA:
undetectable
3k39L-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.39A 3k39M-5jxrA:
undetectable
3k39M-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.40A 3k39N-5jxrA:
undetectable
3k39N-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
LEU A 161
GLU A 132
GLU A 156
ARG A 136
None
1.38A 3k39P-5jxrA:
undetectable
3k39P-5jxrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 HIS A 351
VAL A 386
LEU A 389
TRP A 374
PHE A 371
None
1.12A 3kk6B-5jxrA:
undetectable
3kk6B-5jxrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 10 ILE A 296
THR A 291
VAL A 329
ILE A 330
ILE A 311
None
1.46A 3kpbD-5jxrA:
undetectable
3kpbD-5jxrA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 LEU A 225
LEU A 239
ILE A 290
ILE A 312
PHE A 333
None
1.14A 4a79B-5jxrA:
undetectable
4a79B-5jxrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 LEU A 225
LEU A 239
ILE A 290
ILE A 312
PHE A 333
None
1.14A 4a7aB-5jxrA:
undetectable
4a7aB-5jxrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 6 ILE A 312
LEU A 266
ILE A 290
CYH A 289
None
0.87A 4asdA-5jxrA:
undetectable
4asdA-5jxrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 7 HIS A 466
ASN A 488
TYR A 468
PHE A 528
None
1.36A 4awuA-5jxrA:
undetectable
4awuA-5jxrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 157
GLU A 132
GLU A 156
ARG A 136
ARG A 149
None
1.33A 4cpzH-5jxrA:
undetectable
4cpzH-5jxrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 PHE A 365
LEU A 356
GLY A 101
PHE A 396
THR A 103
None
1.38A 4mubA-5jxrA:
undetectable
4mubA-5jxrA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 11 GLY A 569
GLU A 160
GLN A 514
ASP A 587
GLU A 172
None
1.27A 4qc6A-5jxrA:
0.0
4qc6A-5jxrA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLY A 193
ILE A 198
SER A 199
ILE A 603
ALA A 192
None
1.17A 4qtuD-5jxrA:
undetectable
4qtuD-5jxrA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 7 ASN A 129
GLU A 130
GLU A 131
GLU A 124
None
1.36A 4r87I-5jxrA:
undetectable
4r87I-5jxrA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 VAL A 457
LEU A 454
VAL A 624
ILE A 620
GLY A 169
None
0.96A 4y8wC-5jxrA:
undetectable
4y8wC-5jxrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 ILE A 573
ARG A 602
PHE A 562
LEU A 510
CYH A 534
None
1.29A 5fhzA-5jxrA:
undetectable
5fhzA-5jxrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 4 LEU A 571
LEU A 102
GLY A 101
GLU A 543
None
0.93A 5hhjA-5jxrA:
undetectable
5hhjA-5jxrA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
5 / 12 GLU A 523
ARG A 151
ILE A 486
LEU A 485
LEU A 499
None
1.15A 5toaB-5jxrA:
undetectable
5toaB-5jxrA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
3 / 3 ARG A 567
ARG A 136
ARG A  97
None
0.97A 6bplA-5jxrA:
1.8
6bplB-5jxrA:
2.9
6bplA-5jxrA:
8.61
6bplB-5jxrA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 4 LEU A 161
ASP A 158
GLN A 459
VAL A 417
None
1.32A 6bzoF-5jxrA:
undetectable
6bzoF-5jxrA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila)
4 / 7 ARG A 535
TYR A 533
GLU A 523
ASP A 520
None
1.25A 6mn5B-5jxrA:
undetectable
6mn5B-5jxrA:
8.41