SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 PHE A 348
PRO A 329
THR A 120
ILE A 387
MET A 325
 HEM  A 501 (-3.9A)
None
None
None
HEM  A 501 (-3.5A)
 1.40A 1fm4A-5jxuA:
0.4		 1fm4A-5jxuA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 ILE A 167
THR A 182
ALA A 186
GLY A  72
LEU A 164
 None
 1.05A 1rjdA-5jxuA:
undetectable		 1rjdA-5jxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 ILE A 167
THR A 182
ALA A 186
GLY A  72
LEU A 164
 None
 1.02A 1rjdB-5jxuA:
undetectable		 1rjdB-5jxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 ILE A 167
THR A 182
ALA A 186
GLY A  72
LEU A 164
 None
 1.04A 1rjdC-5jxuA:
undetectable		 1rjdC-5jxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 GLY A 381
GLY A  72
GLY A 161
LEU A 163
THR A 182
 None
 0.94A 2wa2B-5jxuA:
undetectable		 2wa2B-5jxuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 5 VAL A 252
GLN A 196
PHE A 125
ARG A 255
 None
 1.46A 3bjwE-5jxuA:
undetectable		 3bjwE-5jxuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		3 / 3 ARG A  97
ASP A 185
ASP A  93
 None
 0.84A 3jayA-5jxuA:
undetectable		 3jayA-5jxuA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		3 / 3 ARG A  97
ASP A 185
ASP A  93
 None
 0.89A 3jb2A-5jxuA:
undetectable		 3jb2A-5jxuA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 11 THR A  79
LEU A  75
LEU A  73
LEU A  84
LEU A  87
 None
 1.28A 3ndvA-5jxuA:
undetectable
3ndvB-5jxuA:
undetectable		 3ndvA-5jxuA:
22.41
3ndvB-5jxuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 11 LEU A  84
LEU A  87
THR A  79
LEU A  75
LEU A  73
 None
 1.25A 3ndvA-5jxuA:
undetectable
3ndvB-5jxuA:
undetectable		 3ndvA-5jxuA:
22.41
3ndvB-5jxuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 11 THR A  79
LEU A  75
LEU A  73
LEU A  84
LEU A  87
 None
 1.27A 3ndvC-5jxuA:
undetectable
3ndvD-5jxuA:
undetectable		 3ndvC-5jxuA:
22.41
3ndvD-5jxuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 7 TYR A 351
LEU A 163
LEU A 251
PHE A  70
 None
 1.28A 3nk2X-5jxuA:
undetectable		 3nk2X-5jxuA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		3 / 3 ARG A  86
LEU A  90
THR A 190
 None
 0.90A 3oxcA-5jxuA:
undetectable		 3oxcA-5jxuA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 LEU A 164
LEU A  71
MET A  88
LEU A  91
ILE A 387
 None
 1.23A 4j24B-5jxuA:
undetectable		 4j24B-5jxuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		3 / 3 ARG A 102
GLU A 393
ARG A  97
 None
 0.96A 4mwvA-5jxuA:
undetectable		 4mwvA-5jxuA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 9 LEU A 143
GLY A 142
ILE A 387
LEU A 251
VAL A 384
 None
 1.06A 4x3mB-5jxuA:
undetectable		 4x3mB-5jxuA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 10 GLY A  72
VAL A 165
MET A  88
LEU A  75
LEU A  91
 None
 1.07A 4yb6A-5jxuA:
1.5
4yb6E-5jxuA:
1.5		 4yb6A-5jxuA:
20.25
4yb6E-5jxuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 10 GLY A  72
VAL A 165
MET A  88
LEU A  75
LEU A  91
 None
 1.08A 4yb6C-5jxuA:
1.7
4yb6F-5jxuA:
1.6		 4yb6C-5jxuA:
20.25
4yb6F-5jxuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 10 MET A  88
LEU A  75
LEU A  91
GLY A  72
VAL A 165
 None
 1.06A 4yb6A-5jxuA:
1.5
4yb6D-5jxuA:
1.5		 4yb6A-5jxuA:
20.25
4yb6D-5jxuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 10 MET A  88
LEU A  75
LEU A  91
GLY A  72
VAL A 165
 None
 1.08A 4yb6B-5jxuA:
1.5
4yb6F-5jxuA:
1.0		 4yb6B-5jxuA:
20.25
4yb6F-5jxuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		3 / 3 ASP A 343
ARG A 257
TYR A 332
 None
 0.99A 5a7mA-5jxuA:
undetectable		 5a7mA-5jxuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		3 / 3 ASP A 343
ARG A 257
TYR A 332
 None
 0.97A 5a7mB-5jxuA:
undetectable		 5a7mB-5jxuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 8 PHE A 348
PRO A 329
LEU A 347
LEU A 346
 HEM  A 501 (-3.9A)
None
None
HEM  A 501 ( 4.3A)
 0.97A 5dzkd-5jxuA:
undetectable
5dzkr-5jxuA:
undetectable		 5dzkd-5jxuA:
20.68
5dzkr-5jxuA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 8 PHE A 348
PRO A 329
LEU A 347
LEU A 346
 HEM  A 501 (-3.9A)
None
None
HEM  A 501 ( 4.3A)
 0.88A 5dzkF-5jxuA:
undetectable
5dzkT-5jxuA:
undetectable		 5dzkF-5jxuA:
20.68
5dzkT-5jxuA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 5 LEU A  75
PHE A 189
LEU A 163
PHE A 125
 None
 1.12A 5iy5P-5jxuA:
undetectable
5iy5W-5jxuA:
undetectable		 5iy5P-5jxuA:
20.25
5iy5W-5jxuA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 12 ARG A 246
GLY A  54
ALA A 353
THR A 250
GLY A 390
 None
 1.02A 5veuH-5jxuA:
undetectable		 5veuH-5jxuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 6 LEU A  75
PHE A 189
LEU A 163
PHE A 125
 None
 1.13A 5w97C-5jxuA:
undetectable
5w97J-5jxuA:
undetectable		 5w97C-5jxuA:
20.49
5w97J-5jxuA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 5 LEU A  75
PHE A 189
LEU A 163
PHE A 125
 None
 1.05A 5x1fC-5jxuA:
undetectable
5x1fJ-5jxuA:
undetectable		 5x1fC-5jxuA:
20.49
5x1fJ-5jxuA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		4 / 5 LEU A  75
PHE A 189
LEU A 163
PHE A 125
 None
 1.14A 5xdxP-5jxuA:
undetectable
5xdxW-5jxuA:
undetectable		 5xdxP-5jxuA:
20.25
5xdxW-5jxuA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5jxu DYP-TYPE PEROXIDASE
FAMILY
(Thermomonospora
curvata) 		5 / 11 THR A  62
VAL A 252
LEU A 251
ALA A  58
VAL A 236
 None
 1.34A 6dryA-5jxuA:
undetectable		 6dryA-5jxuA:
21.45