SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 11	ILE A 18 VAL A 22 ALA A 23 PHE A 26 ILE A 35	NAD A 301 (-3.8A) None None None None	0.77A	1uduA-5jy1A: undetectable	1uduA-5jy1A: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UKB_A_BEZA1300_0 (2-HYDROXY-6-OXO-7-ME THYLOCTA-2,4-DIENOAT E HYDROLASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 11	GLY A 224 ALA A 227 ALA A 231 VAL A 11 VAL A 88	None	1.13A	1ukbA-5jy1A: 4.5	1ukbA-5jy1A: 21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UKB_A_BEZA1300_0 (2-HYDROXY-6-OXO-7-ME THYLOCTA-2,4-DIENOAT E HYDROLASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	6 / 11	GLY A 224 SER A 25 ALA A 227 ALA A 231 LEU A 4 VAL A 88	None	1.44A	1ukbA-5jy1A: 4.5	1ukbA-5jy1A: 21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QE6_A_SAMA400_0 (UNCHARACTERIZED PROTEIN TFU_2867)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 ILE A 38 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) NAD A 301 (-3.7A) NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.81A	2qe6A-5jy1A: 5.2	2qe6A-5jy1A: 22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 15 ILE A 38 ASN A 39 ASP A 63 VAL A 64	NAD A 301 ( 4.2A) NAD A 301 (-3.7A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.86A	2zzmA-5jy1A: 6.8	2zzmA-5jy1A: 23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 15 ILE A 38 ASN A 39 ASP A 63 VAL A 64	NAD A 301 ( 4.2A) NAD A 301 (-3.7A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.98A	2zznA-5jy1A: 6.9	2zznA-5jy1A: 23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AY0_B_ADNB402_1 (UNCHARACTERIZED PROTEIN MJ0883)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 10	GLY A 15 ILE A 38 ASN A 39 ASP A 63 VAL A 64	NAD A 301 ( 4.2A) NAD A 301 (-3.7A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.90A	3ay0B-5jy1A: 7.0	3ay0B-5jy1A: 23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRV_A_ADNA300_1 (DIMETHYLADENOSINE TRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 11	GLY A 13 GLY A 16 GLU A 37 ILE A 38 ASP A 63	NAD A 301 (-3.4A) NAD A 301 (-4.2A) NAD A 301 (-2.8A) NAD A 301 (-3.7A) NAD A 301 (-3.8A)	0.50A	3grvA-5jy1A: 6.0	3grvA-5jy1A: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRY_A_SAMA300_0 (DIMETHYLADENOSINE TRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 16 GLU A 37 ILE A 38 ASP A 63	NAD A 301 (-3.4A) NAD A 301 (-4.2A) NAD A 301 (-2.8A) NAD A 301 (-3.7A) NAD A 301 (-3.8A)	0.49A	3gryA-5jy1A: 6.0	3gryA-5jy1A: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P97_A_SAMA263_0 (NON-STRUCTURAL PROTEIN 5)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.87A	3p97A-5jy1A: 5.5	3p97A-5jy1A: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTK_A_SAMA1263_0 (POLYPROTEIN)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.90A	4ctkA-5jy1A: 5.4	4ctkA-5jy1A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DMG_B_SAMB401_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA1493)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 11	ASP A 222 ASP A 218 ALA A 226 ASP A 246 PRO A 186	None None None None NAD A 301 (-4.5A)	1.41A	4dmgB-5jy1A: 8.4	4dmgB-5jy1A: 23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1W_A_STRA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	4 / 7	VAL A 164 ILE A 163 LEU A 108 LEU A 112	None	1.04A	4l1wA-5jy1A: undetectable	4l1wA-5jy1A: 24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EC8_C_SAMC4000_0 (GENOME POLYPROTEIN)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.89A	5ec8C-5jy1A: 2.5	5ec8C-5jy1A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EHG_A_SAMA301_0 (RNA-DIRECTED RNA POLYMERASE NS5)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.91A	5ehgA-5jy1A: 5.3	5ehgA-5jy1A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EHI_A_SAMA4001_0 (NS5 METHYLTRANSFERASE DENGUE VIRUS)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.91A	5ehiA-5jy1A: undetectable	5ehiA-5jy1A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_C_SAMC4000_0 (GENOME POLYPROTEIN)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.90A	5eifC-5jy1A: 3.6	5eifC-5jy1A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FA8_A_SAMA301_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 16 ILE A 18 ASN A 39 PHE A 92	NAD A 301 (-3.4A) NAD A 301 (-4.2A) NAD A 301 (-3.8A) None ACT A 304 ( 4.0A)	0.98A	5fa8A-5jy1A: 5.9	5fa8A-5jy1A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FA8_A_SAMA301_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 19 GLY A 21 ILE A 223 ILE A 35 ARG A 24	None	1.10A	5fa8A-5jy1A: 5.9	5fa8A-5jy1A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GLM_A_ACTA613_0 (GLYCOSIDE HYDROLASE FAMILY 43)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	3 / 3	ASP A 145 SER A 256 TYR A 254	None	0.84A	5glmA-5jy1A: undetectable	5glmA-5jy1A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HJI_A_ADNA401_1 (TRNA (GUANINE(37)-N1)-MET HYLTRANSFERASE TRM5A)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	6 / 11	GLY A 15 GLU A 37 ILE A 38 ASN A 39 ASP A 63 VAL A 64	NAD A 301 ( 4.2A) NAD A 301 (-2.8A) NAD A 301 (-3.7A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.70A	5hjiA-5jy1A: 6.7	5hjiA-5jy1A: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGP_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	ILE A 184 GLU A 233 ALA A 9 VAL A 11 LEU A 84	None	0.85A	5igpA-5jy1A: undetectable	5igpA-5jy1A: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_B_SAMB401_0 (PAVINE N-METHYLTRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 ASP A 63 VAL A 64 THR A 65	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) NAD A 301 (-3.8A) NAD A 301 (-3.6A) NAD A 301 ( 4.1A)	0.66A	5kpcB-5jy1A: undetectable	5kpcB-5jy1A: 20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQR_A_SAMA301_0 (METHYLTRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.92A	5kqrA-5jy1A: 5.1	5kqrA-5jy1A: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQS_A_SAMA307_0 (GENOME POLYPROTEIN)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.88A	5kqsA-5jy1A: 2.4	5kqsA-5jy1A: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5B_A_SAMA1001_0 (NS5 METHYLTRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.94A	5m5bA-5jy1A: 3.5	5m5bA-5jy1A: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5D_A_SAMA306_0 (METHYLTRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	ALA A 23 VAL A 22 ALA A 118 PHE A 141 ALA A 91	None None None NAD A 301 (-4.8A) NAD A 301 (-3.8A)	1.15A	5n5dA-5jy1A: 8.0	5n5dA-5jy1A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_A_SAMA301_0 (NS5)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.90A	5njvA-5jy1A: 5.4	5njvA-5jy1A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_B_SAMB301_0 (NS5)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.90A	5njvB-5jy1A: 4.5	5njvB-5jy1A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_B_C2FB702_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	4 / 5	ASP A 145 ASN A 157 ASP A 155 ASN A 97	None None EDO A 303 ( 4.2A) None	1.20A	5vooB-5jy1A: 2.2	5vooB-5jy1A: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WY0_A_SAMA800_0 (SMALL RNA 2'-O-METHYLTRANSFERA SE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 ILE A 38 ASN A 39 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) NAD A 301 (-3.7A) None NAD A 301 (-3.6A)	0.62A	5wy0A-5jy1A: 5.5	5wy0A-5jy1A: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_B_SAMB601_0 (NS5 METHYLTRANSFERASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.82A	5wz1B-5jy1A: 5.1	5wz1B-5jy1A: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ2_A_SAMA601_0 (NS5 MTASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.84A	5wz2A-5jy1A: 3.2	5wz2A-5jy1A: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ2_B_SAMB601_0 (NS5 MTASE)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 13 GLY A 15 GLY A 21 ASP A 63 VAL A 64	NAD A 301 (-3.4A) NAD A 301 ( 4.2A) None NAD A 301 (-3.8A) NAD A 301 (-3.6A)	0.83A	5wz2B-5jy1A: 3.9	5wz2B-5jy1A: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7F_A_SAMA301_0 (PUTATIVE O-METHYLTRANSFERASE RV1220C)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	GLY A 17 GLY A 13 GLY A 15 ILE A 38 ALA A 91	NAD A 301 (-3.3A) NAD A 301 (-3.4A) NAD A 301 ( 4.2A) NAD A 301 (-3.7A) NAD A 301 (-3.8A)	0.97A	5x7fA-5jy1A: 7.6	5x7fA-5jy1A: 26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5jy1	PUTATIVE SHORT-CHAIN DEHYDROGENASE/REDUCT ASE (Paraburkholderia xenovorans)	5 / 12	ALA A 125 LEU A 84 VAL A 228 THR A 12 ALA A 36	ACT A 306 ( 4.1A) None None None None	1.14A	6djzC-5jy1A: undetectable	6djzC-5jy1A: 21.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UDU_A_CIAA1003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"ILE A  18;VAL A  22;ALA A  23;PHE A  26;ILE A  35","NAD A 301 (-3.8A);None;None;None;None","0.77A","1uduA-5jy1A:undetectable","1uduA-5jy1A:20.72"],["1UKB_A_BEZA1300_0","2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE HYDROLASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A 224;ALA A 227;ALA A 231;VAL A  11;VAL A  88","None","1.13A","1ukbA-5jy1A:4.5","1ukbA-5jy1A:21.64"],["1UKB_A_BEZA1300_0","2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE HYDROLASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",6,"GLY A 224;SER A  25;ALA A 227;ALA A 231;LEU A   4;VAL A  88","None","1.44A","1ukbA-5jy1A:4.5","1ukbA-5jy1A:21.64"],["2QE6_A_SAMA400_0","UNCHARACTERIZED PROTEIN TFU_2867","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;ILE A  38;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);NAD A 301 (-3.7A);NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.81A","2qe6A-5jy1A:5.2","2qe6A-5jy1A:22.95"],["2ZZM_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  15;ILE A  38;ASN A  39;ASP A  63;VAL A  64","NAD A 301 ( 4.2A);NAD A 301 (-3.7A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.86A","2zzmA-5jy1A:6.8","2zzmA-5jy1A:23.03"],["2ZZN_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  15;ILE A  38;ASN A  39;ASP A  63;VAL A  64","NAD A 301 ( 4.2A);NAD A 301 (-3.7A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.98A","2zznA-5jy1A:6.9","2zznA-5jy1A:23.03"],["3AY0_B_ADNB402_1","UNCHARACTERIZED PROTEIN MJ0883","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  15;ILE A  38;ASN A  39;ASP A  63;VAL A  64","NAD A 301 ( 4.2A);NAD A 301 (-3.7A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.90A","3ay0B-5jy1A:7.0","3ay0B-5jy1A:23.03"],["3GRV_A_ADNA300_1","DIMETHYLADENOSINE TRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  16;GLU A  37;ILE A  38;ASP A  63","NAD A 301 (-3.4A);NAD A 301 (-4.2A);NAD A 301 (-2.8A);NAD A 301 (-3.7A);NAD A 301 (-3.8A)","0.50A","3grvA-5jy1A:6.0","3grvA-5jy1A:20.13"],["3GRY_A_SAMA300_0","DIMETHYLADENOSINE TRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  16;GLU A  37;ILE A  38;ASP A  63","NAD A 301 (-3.4A);NAD A 301 (-4.2A);NAD A 301 (-2.8A);NAD A 301 (-3.7A);NAD A 301 (-3.8A)","0.49A","3gryA-5jy1A:6.0","3gryA-5jy1A:20.13"],["3P97_A_SAMA263_0","NON-STRUCTURAL PROTEIN 5","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.87A","3p97A-5jy1A:5.5","3p97A-5jy1A:19.43"],["4CTK_A_SAMA1263_0","POLYPROTEIN","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.90A","4ctkA-5jy1A:5.4","4ctkA-5jy1A:20.65"],["4DMG_B_SAMB401_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1493","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"ASP A 222;ASP A 218;ALA A 226;ASP A 246;PRO A 186","None;None;None;None;NAD A 301 (-4.5A)","1.41A","4dmgB-5jy1A:8.4","4dmgB-5jy1A:23.68"],["4L1W_A_STRA402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",4,"VAL A 164;ILE A 163;LEU A 108;LEU A 112","None","1.04A","4l1wA-5jy1A:undetectable","4l1wA-5jy1A:24.71"],["5EC8_C_SAMC4000_0","GENOME POLYPROTEIN","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.89A","5ec8C-5jy1A:2.5","5ec8C-5jy1A:20.65"],["5EHG_A_SAMA301_0","RNA-DIRECTED RNA POLYMERASE NS5","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.91A","5ehgA-5jy1A:5.3","5ehgA-5jy1A:20.65"],["5EHI_A_SAMA4001_0","NS5 METHYLTRANSFERASE DENGUE VIRUS","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.91A","5ehiA-5jy1A:undetectable","5ehiA-5jy1A:20.65"],["5EIF_C_SAMC4000_0","GENOME POLYPROTEIN","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.90A","5eifC-5jy1A:3.6","5eifC-5jy1A:20.65"],["5FA8_A_SAMA301_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  16;ILE A  18;ASN A  39;PHE A  92","NAD A 301 (-3.4A);NAD A 301 (-4.2A);NAD A 301 (-3.8A);None;ACT A 304 ( 4.0A)","0.98A","5fa8A-5jy1A:5.9","5fa8A-5jy1A:21.40"],["5FA8_A_SAMA301_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  19;GLY A  21;ILE A 223;ILE A  35;ARG A  24","None","1.10A","5fa8A-5jy1A:5.9","5fa8A-5jy1A:21.40"],["5GLM_A_ACTA613_0","GLYCOSIDE HYDROLASE FAMILY 43","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",3,"ASP A 145;SER A 256;TYR A 254","None","0.84A","5glmA-5jy1A:undetectable","5glmA-5jy1A:21.82"],["5HJI_A_ADNA401_1","TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE TRM5A","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",6,"GLY A  15;GLU A  37;ILE A  38;ASN A  39;ASP A  63;VAL A  64","NAD A 301 ( 4.2A);NAD A 301 (-2.8A);NAD A 301 (-3.7A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.70A","5hjiA-5jy1A:6.7","5hjiA-5jy1A:23.63"],["5IGP_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"ILE A 184;GLU A 233;ALA A   9;VAL A  11;LEU A  84","None","0.85A","5igpA-5jy1A:undetectable","5igpA-5jy1A:22.12"],["5KPC_B_SAMB401_0","PAVINE N-METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;ASP A  63;VAL A  64;THR A  65","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);NAD A 301 (-3.8A);NAD A 301 (-3.6A);NAD A 301 ( 4.1A)","0.66A","5kpcB-5jy1A:undetectable","5kpcB-5jy1A:20.91"],["5KQR_A_SAMA301_0","METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.92A","5kqrA-5jy1A:5.1","5kqrA-5jy1A:21.95"],["5KQS_A_SAMA307_0","GENOME POLYPROTEIN","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.88A","5kqsA-5jy1A:2.4","5kqsA-5jy1A:21.95"],["5M5B_A_SAMA1001_0","NS5 METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.94A","5m5bA-5jy1A:3.5","5m5bA-5jy1A:22.11"],["5N5D_A_SAMA306_0","METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"ALA A  23;VAL A  22;ALA A 118;PHE A 141;ALA A  91","None;None;None;NAD A 301 (-4.8A);NAD A 301 (-3.8A)","1.15A","5n5dA-5jy1A:8.0","5n5dA-5jy1A:21.43"],["5NJV_A_SAMA301_0","NS5","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.90A","5njvA-5jy1A:5.4","5njvA-5jy1A:20.00"],["5NJV_B_SAMB301_0","NS5","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.90A","5njvB-5jy1A:4.5","5njvB-5jy1A:20.00"],["5VOO_B_C2FB702_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",4,"ASP A 145;ASN A 157;ASP A 155;ASN A  97","None;None;EDO A 303 ( 4.2A);None","1.20A","5vooB-5jy1A:2.2","5vooB-5jy1A:23.91"],["5WY0_A_SAMA800_0","SMALL RNA 2'-O-METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;ILE A  38;ASN A  39;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);NAD A 301 (-3.7A);None;NAD A 301 (-3.6A)","0.62A","5wy0A-5jy1A:5.5","5wy0A-5jy1A:19.08"],["5WZ1_B_SAMB601_0","NS5 METHYLTRANSFERASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.82A","5wz1B-5jy1A:5.1","5wz1B-5jy1A:22.93"],["5WZ2_A_SAMA601_0","NS5 MTASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.84A","5wz2A-5jy1A:3.2","5wz2A-5jy1A:22.93"],["5WZ2_B_SAMB601_0","NS5 MTASE","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  13;GLY A  15;GLY A  21;ASP A  63;VAL A  64","NAD A 301 (-3.4A);NAD A 301 ( 4.2A);None;NAD A 301 (-3.8A);NAD A 301 (-3.6A)","0.83A","5wz2B-5jy1A:3.9","5wz2B-5jy1A:22.93"],["5X7F_A_SAMA301_0","PUTATIVE O-METHYLTRANSFERASE RV1220C","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"GLY A  17;GLY A  13;GLY A  15;ILE A  38;ALA A  91","NAD A 301 (-3.3A);NAD A 301 (-3.4A);NAD A 301 ( 4.2A);NAD A 301 (-3.7A);NAD A 301 (-3.8A)","0.97A","5x7fA-5jy1A:7.6","5x7fA-5jy1A:26.67"],["6DJZ_C_GMJC301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","5jy1","PUTATIVE SHORT-CHAIN DEHYDROGENASE\/REDUCTASE","Paraburkholderia xenovorans",5,"ALA A 125;LEU A  84;VAL A 228;THR A  12;ALA A  36","ACT A 306 ( 4.1A);None;None;None;None","1.14A","6djzC-5jy1A:undetectable","6djzC-5jy1A:21.53"]]