SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 SER A 206
VAL A 207
TYR A 219
GLY A 250
PRO A 251
 NAD  A 901 (-3.1A)
None
NAD  A 901 (-4.6A)
IOD  A 903 (-4.5A)
IOD  A 903 (-4.4A)
 0.64A 1equA-5jydA:
25.7		 1equA-5jydA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 206
VAL A 207
TYR A 219
GLY A 250
PRO A 251
 NAD  A 901 (-3.1A)
None
NAD  A 901 (-4.6A)
IOD  A 903 (-4.5A)
IOD  A 903 (-4.4A)
 0.42A 1fdsA-5jydA:
25.4		 1fdsA-5jydA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 206
VAL A 207
TYR A 219
GLY A 250
PRO A 251
 NAD  A 901 (-3.1A)
None
NAD  A 901 (-4.6A)
IOD  A 903 (-4.5A)
IOD  A 903 (-4.4A)
 0.64A 1fduA-5jydA:
25.6		 1fduA-5jydA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 206
VAL A 207
TYR A 219
GLY A 250
PRO A 251
 NAD  A 901 (-3.1A)
None
NAD  A 901 (-4.6A)
IOD  A 903 (-4.5A)
IOD  A 903 (-4.4A)
 0.61A 1fduC-5jydA:
25.4		 1fduC-5jydA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A  67
VAL A  96
ILE A  98
GLY A  77
GLY A  82
 None
 1.03A 1k6cA-5jydA:
undetectable		 1k6cA-5jydA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 PRO A 249
GLY A  80
SER A  79
ALA A 286
ALA A  85
 NAD  A 901 (-3.9A)
NAD  A 901 (-3.0A)
MG  A 902 ( 2.1A)
None
None
 1.31A 1nw5A-5jydA:
2.2		 1nw5A-5jydA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ARG A 211
TYR A 219
GLN A 257
SER A 274
 IOD  A 904 ( 3.8A)
NAD  A 901 (-4.6A)
NAD  A 901 (-3.7A)
None
 1.20A 1nx9A-5jydA:
3.6		 1nx9A-5jydA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ARG A 211
TYR A 219
GLN A 257
SER A 274
 IOD  A 904 ( 3.8A)
NAD  A 901 (-4.6A)
NAD  A 901 (-3.7A)
None
 1.20A 1nx9B-5jydA:
5.2		 1nx9B-5jydA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ARG A 211
TYR A 219
GLN A 257
SER A 274
 IOD  A 904 ( 3.8A)
NAD  A 901 (-4.6A)
NAD  A 901 (-3.7A)
None
 1.21A 1nx9C-5jydA:
3.5		 1nx9C-5jydA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ARG A 211
TYR A 219
GLN A 257
SER A 274
 IOD  A 904 ( 3.8A)
NAD  A 901 (-4.6A)
NAD  A 901 (-3.7A)
None
 1.18A 1nx9D-5jydA:
4.8		 1nx9D-5jydA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 TYR A 289
ILE A  81
ALA A  86
LEU A  73
ILE A  98
 None
NAD  A 901 (-3.8A)
None
None
None
 1.16A 1uduA-5jydA:
undetectable		 1uduA-5jydA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 TYR A 289
ILE A  81
ALA A  86
PHE A  89
ILE A  98
 None
NAD  A 901 (-3.8A)
None
None
None
 1.09A 1uduA-5jydA:
undetectable		 1uduA-5jydA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  77
ILE A  81
ALA A 286
ILE A 115
HIS A  56
 None
NAD  A 901 (-3.8A)
None
None
None
 1.12A 1ve3A-5jydA:
6.5		 1ve3A-5jydA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  77
ILE A  81
ALA A 286
ILE A 115
HIS A  56
 None
NAD  A 901 (-3.8A)
None
None
None
 0.96A 1ve3B-5jydA:
6.3		 1ve3B-5jydA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 SER A 259
LEU A 256
GLY A  80
ILE A  98
 None
NAD  A 901 (-3.6A)
NAD  A 901 (-3.0A)
None
 0.92A 2bdmA-5jydA:
undetectable		 2bdmA-5jydA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 GLY A  99
GLU A 104
ALA A  97
VAL A  96
PHE A  89
 None
NAD  A 901 ( 2.6A)
None
None
None
 1.22A 2drdA-5jydA:
undetectable		 2drdA-5jydA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 292
VAL A  74
ILE A  81
ALA A 307
PHE A  89
 None
None
NAD  A 901 (-3.8A)
None
None
 1.18A 2gj5A-5jydA:
undetectable		 2gj5A-5jydA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 154
ILE A  81
LEU A 256
TYR A 219
ALA A 248
 None
NAD  A 901 (-3.8A)
NAD  A 901 (-3.6A)
NAD  A 901 (-4.6A)
None
 1.32A 2iyfB-5jydA:
5.8		 2iyfB-5jydA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 110
HIS A  56
GLU A  58
 IOD  A 908 ( 4.4A)
None
None
 0.77A 2x45B-5jydA:
undetectable		 2x45B-5jydA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 110
HIS A  56
GLU A  58
 IOD  A 908 ( 4.4A)
None
None
 0.79A 2x45C-5jydA:
undetectable		 2x45C-5jydA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 SER A 274
GLY A 277
GLY A 309
GLY A 280
 None
 0.90A 3bogB-5jydA:
undetectable
3bogD-5jydA:
undetectable		 3bogB-5jydA:
undetectable
3bogD-5jydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 ASN A 245
ALA A 300
ARG A 243
 None
 0.73A 3tj7C-5jydA:
undetectable
3tj7D-5jydA:
undetectable		 3tj7C-5jydA:
17.92
3tj7D-5jydA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 TYR A 252
GLY A  82
GLY A  80
ILE A  87
ALA A  85
 None
None
NAD  A 901 (-3.0A)
None
None
 1.11A 4qtuB-5jydA:
6.7		 4qtuB-5jydA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  93
ALA A  94
ILE A 151
THR A  72
VAL A 153
 None
 0.92A 4xdrA-5jydA:
undetectable		 4xdrA-5jydA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 GLN A 257
GLN A 159
PRO A 263
ALA A 161
 NAD  A 901 (-3.7A)
None
None
None
 1.34A 5odcA-5jydA:
1.8
5odcG-5jydA:
4.2		 5odcA-5jydA:
19.05
5odcG-5jydA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A 263
ALA A 161
GLN A 257
GLN A 159
 None
None
NAD  A 901 (-3.7A)
None
 1.34A 5odcA-5jydA:
1.9
5odcG-5jydA:
2.0		 5odcA-5jydA:
19.05
5odcG-5jydA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 TYR A 289
PRO A  54
THR A 254
THR A 204
VAL A 153
 None
None
NAD  A 901 (-2.9A)
NAD  A 901 (-4.0A)
None
 1.37A 5wggA-5jydA:
0.0		 5wggA-5jydA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5jyd SHORT CHAIN
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  80
GLU A 110
VAL A 111
LEU A 114
ILE A 115
 NAD  A 901 (-3.0A)
IOD  A 908 ( 4.4A)
None
None
None
 0.77A 6ectA-5jydA:
4.8		 6ectA-5jydA:
23.86