SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 12 ILE A  16
GLY A  15
LEU A 341
LEU A 333
TYR A 337
 None
 1.30A 1fm6X-5jygA:
undetectable		 1fm6X-5jygA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 11 LEU A  79
ILE A  82
GLU A 133
LEU A  94
LEU A  93
 None
 1.31A 1mrqA-5jygA:
undetectable		 1mrqA-5jygA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 12 ILE A 261
THR A 167
ASP A 161
GLY A 290
GLY A 288
 None
None
MG  A 401 (-3.8A)
None
ADP  A 402 ( 4.2A)
 1.02A 1rjdA-5jygA:
undetectable		 1rjdA-5jygA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 12 ILE A 261
THR A 167
ASP A 161
GLY A 290
GLY A 288
 None
None
MG  A 401 (-3.8A)
None
ADP  A 402 ( 4.2A)
 0.99A 1rjdB-5jygA:
undetectable		 1rjdB-5jygA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 12 ILE A 261
THR A 167
ASP A 161
GLY A 290
GLY A 288
 None
None
MG  A 401 (-3.8A)
None
ADP  A 402 ( 4.2A)
 1.03A 1rjdC-5jygA:
undetectable		 1rjdC-5jygA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 12 ALA A 253
SER A 222
GLY A 225
THR A 226
THR A 228
 None
ADP  A 402 (-3.5A)
None
None
None
 1.15A 2zifA-5jygA:
undetectable		 2zifA-5jygA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 PRO A 103
HIS A 136
LEU A  14
ALA A 101
 None
 1.31A 3gv1A-5jygA:
undetectable
3gv1C-5jygA:
undetectable		 3gv1A-5jygA:
17.29
3gv1C-5jygA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 11 ARG A 292
GLY A  19
LEU A  34
THR A  23
ALA A  24
 ADP  A 402 (-4.3A)
ADP  A 402 (-3.1A)
None
None
None
 0.99A 3kw2A-5jygA:
undetectable		 3kw2A-5jygA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 11 ARG A 292
GLY A  19
LEU A  34
THR A  23
ALA A  24
 ADP  A 402 (-4.3A)
ADP  A 402 (-3.1A)
None
None
None
 1.05A 3kw2B-5jygA:
undetectable		 3kw2B-5jygA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 9 GLY A 288
ALA A 287
ASP A 161
ILE A 159
GLY A 322
 ADP  A 402 ( 4.2A)
None
MG  A 401 (-3.8A)
None
None
 1.04A 3ogpB-5jygA:
undetectable		 3ogpB-5jygA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ASP A  17
GLY A 322
VAL A 315
HIS A  22
 MG  A 401 ( 4.6A)
None
None
None
 0.85A 4c5nC-5jygA:
undetectable		 4c5nC-5jygA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ARG A 305
GLU A 263
ILE A 262
ASP A 260
 None
 1.13A 4d33A-5jygA:
undetectable		 4d33A-5jygA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 7 ARG A 305
GLU A 263
ILE A 262
ASP A 260
 None
 1.12A 4d33B-5jygA:
undetectable		 4d33B-5jygA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ARG A 305
GLU A 263
ILE A 262
ASP A 260
 None
 1.07A 4d39A-5jygA:
undetectable		 4d39A-5jygA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 7 ARG A 305
GLU A 263
ILE A 262
ASP A 260
 None
 1.11A 4d39B-5jygA:
undetectable		 4d39B-5jygA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		3 / 3 LEU A 196
ILE A 200
ARG A 203
 None
 0.65A 4mk4B-5jygA:
undetectable		 4mk4B-5jygA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 TYR A 276
ASN A 156
GLU A 180
LEU A 268
 None
 1.30A 4twdB-5jygA:
undetectable
4twdC-5jygA:
undetectable		 4twdB-5jygA:
22.52
4twdC-5jygA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 TYR A 276
ASN A 156
GLU A 180
LEU A 268
 None
 1.27A 4twdD-5jygA:
undetectable
4twdE-5jygA:
undetectable		 4twdD-5jygA:
22.52
4twdE-5jygA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 ARG A  71
ILE A  70
ILE A  82
ASP A  84
 None
 1.20A 4w5qA-5jygA:
4.7		 4w5qA-5jygA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 LEU A 269
LEU A 268
ASN A 156
ILE A 158
 None
 0.93A 4ww7A-5jygA:
undetectable		 4ww7A-5jygA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		6 / 12 VAL A 211
ASP A 193
GLY A 189
ALA A 164
THR A  20
VAL A  38
 None
None
None
ADP  A 402 (-3.4A)
ADP  A 402 (-3.4A)
None
 1.19A 4xdrA-5jygA:
undetectable		 4xdrA-5jygA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		6 / 10 GLY A 163
GLY A 189
LYS A 218
SER A 222
GLY A 289
ILE A 293
 ADP  A 402 (-3.5A)
None
ADP  A 402 (-3.1A)
ADP  A 402 (-3.5A)
ADP  A 402 (-3.2A)
None
 1.42A 5aqfC-5jygA:
15.8		 5aqfC-5jygA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		6 / 10 GLY A 163
GLY A 189
LYS A 218
SER A 222
GLY A 289
ILE A 293
 ADP  A 402 (-3.5A)
None
ADP  A 402 (-3.1A)
ADP  A 402 (-3.5A)
ADP  A 402 (-3.2A)
None
 1.36A 5aqyA-5jygA:
20.7		 5aqyA-5jygA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 SER A 291
GLY A 150
ARG A 324
GLY A 322
 None
 0.89A 5cdnR-5jygA:
undetectable
5cdnS-5jygA:
undetectable		 5cdnR-5jygA:
22.97
5cdnS-5jygA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		5 / 12 GLY A  19
HIS A  22
GLY A 163
ASP A 161
LEU A  18
 ADP  A 402 (-3.1A)
None
ADP  A 402 (-3.5A)
MG  A 401 (-3.8A)
None
 1.01A 5hg0B-5jygA:
undetectable		 5hg0B-5jygA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 6 ARG A  71
ILE A  70
ILE A  82
ASP A  84
 None
 1.21A 6cbdA-5jygA:
2.0		 6cbdA-5jygA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ASP A 245
ILE A 200
ARG A 243
ASN A 210
 None
 1.18A 6hisA-5jygA:
undetectable
6hisB-5jygA:
undetectable		 6hisA-5jygA:
12.97
6hisB-5jygA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ASP A 245
ILE A 200
ARG A 243
ASN A 210
 None
 1.17A 6hisB-5jygA:
undetectable
6hisC-5jygA:
undetectable		 6hisB-5jygA:
12.97
6hisC-5jygA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ASP A 245
ILE A 200
ARG A 243
ASN A 210
 None
 1.17A 6hisC-5jygA:
undetectable
6hisD-5jygA:
undetectable		 6hisC-5jygA:
12.97
6hisD-5jygA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ASP A 245
ILE A 200
ARG A 243
ASN A 210
 None
 1.18A 6hisD-5jygA:
undetectable
6hisE-5jygA:
undetectable		 6hisD-5jygA:
12.97
6hisE-5jygA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5jyg ACTIN-LIKE ATPASE
(Magnetospirillum
magneticum) 		4 / 8 ASN A 210
ASP A 245
ILE A 200
ARG A 243
 None
 1.18A 6hisA-5jygA:
undetectable
6hisE-5jygA:
undetectable		 6hisA-5jygA:
12.97
6hisE-5jygA:
12.97