SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5jyl SCFV TSP7
(Mus
musculus) 		6 / 12 TYR B 174
GLN B 227
PHE B 236
VAL B  37
ALA B  97
TRP B 109
 None
 0.59A 1h8sA-5jylB:
22.9		 1h8sA-5jylB:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jyl SCFV TSP7
(Mus
musculus) 		3 / 3 ARG B  99
VAL B  37
TRP B  47
 None
 1.08A 1qw6A-5jylB:
undetectable		 1qw6A-5jylB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jyl SCFV TSP7
(Mus
musculus) 		3 / 3 ARG B  99
VAL B  37
TRP B  47
 None
 1.01A 1qwcA-5jylB:
undetectable		 1qwcA-5jylB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jyl SCFV TSP7
(Mus
musculus) 		3 / 3 ARG B  99
VAL B  37
TRP B  47
 None
 1.01A 1vagA-5jylB:
undetectable		 1vagA-5jylB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jyl SCFV TSP7
(Mus
musculus) 		3 / 3 ARG B  99
VAL B  37
TRP B  47
 None
 1.03A 1zviA-5jylB:
undetectable		 1zviA-5jylB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5jyl CADHERIN-3
(Homo
sapiens) 		4 / 6 LEU A  61
GLN A  23
LEU A  60
GLU A  54
 None
 0.88A 3h5gB-5jylA:
undetectable
3h5gC-5jylA:
undetectable		 3h5gB-5jylA:
19.54
3h5gC-5jylA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5jyl SCFV TSP7
(Mus
musculus) 		3 / 3 ILE B 221
SER B 150
SER B 152
 None
 0.40A 3iltH-5jylB:
undetectable		 3iltH-5jylB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5jyl SCFV TSP7
(Mus
musculus) 		4 / 4 LEU B 153
GLY B 154
LEU B 216
GLU B 217
 None
 0.95A 3tgvB-5jylB:
undetectable		 3tgvB-5jylB:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5jyl SCFV TSP7
(Mus
musculus) 		4 / 5 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 None
None
None
CL  B 303 (-4.9A)
 0.30A 4m7kH-5jylB:
23.5		 4m7kH-5jylB:
47.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5jyl SCFV TSP7
(Mus
musculus) 		5 / 12 VAL B  93
GLU B   6
GLY B 110
TYR B  94
GLN B   1
 PO4  B 302 ( 4.9A)
None
None
None
None
 1.47A 5fhrA-5jylB:
undetectable		 5fhrA-5jylB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jyl SCFV TSP7
(Mus
musculus) 		3 / 3 ARG B  99
VAL B  37
TRP B  47
 None
 1.04A 5fvoA-5jylB:
undetectable		 5fvoA-5jylB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5jyl CADHERIN-3
SCFV TSP7
(Homo
sapiens;
Mus
musculus) 		3 / 3 ASP A  90
SER A  87
TYR B  54
 GOL  B 301 ( 4.7A)
None
GOL  B 301 (-3.9A)
 0.86A 5glmA-5jylA:
undetectable		 5glmA-5jylA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5jyl SCFV TSP7
(Mus
musculus) 		5 / 12 LEU B 184
TYR B 188
TYR B 170
ASN B 172
MET B 142
 None
 1.48A 5kklB-5jylB:
undetectable		 5kklB-5jylB:
12.89