SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Thermosynechococ
cus
elongatus) 		5 / 12 PHE A 713
ILE A 616
THR A 625
LEU A 618
ILE A 704
 None
 1.27A 1kqwA-5jyuA:
undetectable		 1kqwA-5jyuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Thermosynechococ
cus
elongatus) 		5 / 12 PHE A 713
ILE A 616
THR A 625
LEU A 618
LEU A 706
 None
 1.24A 2rctA-5jyuA:
undetectable		 2rctA-5jyuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Thermosynechococ
cus
elongatus) 		3 / 3 LEU A 654
ARG A 650
ILE A 641
 None
 0.60A 2xn5B-5jyuA:
undetectable		 2xn5B-5jyuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Thermosynechococ
cus
elongatus) 		4 / 7 ILE A 704
THR A 625
LEU A 618
VAL A 640
 None
 0.78A 3ua5B-5jyuA:
undetectable		 3ua5B-5jyuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Thermosynechococ
cus
elongatus) 		4 / 5 ILE A 690
ASP A 669
GLU A 663
VAL A 619
 None
 1.22A 4nkxC-5jyuA:
undetectable		 4nkxC-5jyuA:
11.73