SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.40A 1m8dA-5jz7C:
0.0		 1m8dA-5jz7C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.39A 1m8dB-5jz7C:
0.0		 1m8dB-5jz7C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8H_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.39A 1m8hA-5jz7C:
0.0		 1m8hA-5jz7C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8H_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.42A 1m8hB-5jz7C:
0.0		 1m8hB-5jz7C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8I_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.35A 1m8iA-5jz7C:
0.0		 1m8iA-5jz7C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8I_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.44A 1m8iB-5jz7C:
0.0		 1m8iB-5jz7C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.37A 1qomB-5jz7C:
0.0		 1qomB-5jz7C:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 ASP D  85
LYS D 103
PRO D   7
GLY D  99
LEU D   4
 None
 1.29A 2nv4A-5jz7D:
undetectable		 2nv4A-5jz7D:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 ASP D  85
LYS D 103
PRO D   7
GLY D  99
LEU D   4
 None
 1.29A 2nv4B-5jz7D:
undetectable		 2nv4B-5jz7D:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR C  91
TYR D  36
PRO D  44
TYR D  87
 None
 0.68A 2oldA-5jz7C:
14.3
2oldB-5jz7C:
14.3		 2oldA-5jz7C:
21.65
2oldB-5jz7C:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR D  36
PRO D  44
TYR D  87
TYR C  91
 None
 0.65A 2oldA-5jz7D:
20.6
2oldB-5jz7D:
20.4		 2oldA-5jz7D:
39.27
2oldB-5jz7D:
39.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 GLY C  33
ASP C 100
TRP D  96
TYR C 100
 None
 1.24A 3aruA-5jz7C:
6.7		 3aruA-5jz7C:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5jz7 BETA-NERVE GROWTH
FACTOR
MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 ASP C 101
SER C  95
SER A  19
ASP A 105
 None
 1.19A 3bc9A-5jz7C:
6.3		 3bc9A-5jz7C:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E67_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.36A 3e67B-5jz7C:
0.0		 3e67B-5jz7C:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6L_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.48A 3e6lA-5jz7C:
0.0		 3e6lA-5jz7C:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6L_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER C  59
MET C  48
ILE C  69
TRP C  36
 None
 1.42A 3e6lB-5jz7C:
0.0		 3e6lB-5jz7C:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 ASP C 100
SER C  95
ILE C  34
TRP C 103
TYR C  99
 None
 1.50A 3rzeA-5jz7C:
undetectable		 3rzeA-5jz7C:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 ILE C  52
PRO C  52
SER C  96
GLY C  33
 None
 1.17A 3tkdB-5jz7C:
undetectable		 3tkdB-5jz7C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 ILE C  52
PRO C  52
SER C  96
GLY C  33
 None
 1.17A 3tkdA-5jz7C:
undetectable		 3tkdA-5jz7C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5jz7 BETA-NERVE GROWTH
FACTOR
MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN D  52
ASP A  60
ASP A  65
 None
 0.81A 4obwD-5jz7D:
undetectable		 4obwD-5jz7D:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		5 / 7 TYR D  32
SER D  34
TYR D  36
TYR D  49
PRO D  55
 None
 0.73A 5aclA-5jz7D:
20.5		 5aclA-5jz7D:
63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 TYR D  36
GLY D  89
TRP D  91
PHE D  98
 None
 0.64A 5alcL-5jz7D:
21.9		 5alcL-5jz7D:
57.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 SER C  35
VAL C  37
ALA C  60
TRP D  91
GLY C  49
 None
 1.13A 5tzoC-5jz7C:
undetectable		 5tzoC-5jz7C:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5jz7 BETA-NERVE GROWTH
FACTOR
MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PHE A  54
THR C  31
ASP A  24
GLU A  55
 None
 1.48A 5ybbA-5jz7A:
undetectable		 5ybbA-5jz7A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens) 		5 / 10 VAL D  11
LEU D 104
GLY D  77
LEU D  78
GLN D  17
 None
 1.30A 6czmE-5jz7D:
undetectable
6czmF-5jz7D:
undetectable		 6czmE-5jz7D:
15.23
6czmF-5jz7D:
15.23