SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 8 ASP A 721
SER A 722
SER A 563
ARG A 662
 OGA  A 802 ( 4.8A)
None
None
None
 0.95A 1meiA-5jz8A:
undetectable		 1meiA-5jz8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 HIS A 679
HIS A 725
VAL A 727
ARG A 735
SER A 668
 MN  A 801 ( 3.4A)
MN  A 801 ( 3.4A)
OGA  A 802 ( 4.9A)
OGA  A 802 (-2.2A)
OGA  A 802 (-2.5A)
 1.18A 1uofA-5jz8A:
6.9		 1uofA-5jz8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 8 TYR A 667
PHE A 612
ALA A 640
MET A 605
 None
ACT  A 803 (-4.8A)
None
None
 1.00A 1x8vA-5jz8A:
undetectable		 1x8vA-5jz8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 TRP A 576
LEU A 717
LYS A 709
 None
 1.20A 1yajK-5jz8A:
undetectable		 1yajK-5jz8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 645
THR A 649
 None
 0.76A 209dC-5jz8A:
undetectable		 209dC-5jz8A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
COAGULATION FACTOR X
(Homo
sapiens) 		5 / 12 GLY A 663
ASP A 741
PHE A 719
GLY A 681
ASP B 103
 None
None
OGA  A 802 (-4.9A)
None
OGA  A 802 ( 3.2A)
 1.25A 2fqyA-5jz8A:
undetectable		 2fqyA-5jz8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
COAGULATION FACTOR X
(Homo
sapiens;
Homo
sapiens) 		5 / 11 GLY B 104
ASP A 524
GLY B 106
HIS A 530
PHE A 527
 None
 1.34A 2hmaA-5jz8B:
undetectable		 2hmaA-5jz8B:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 7 ARG A 562
LEU A 619
ARG A 703
ILE A 702
 None
 1.08A 3ln1C-5jz8A:
undetectable		 3ln1C-5jz8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 5 ARG A 562
LEU A 619
ARG A 703
ILE A 702
 None
 1.07A 3ln1D-5jz8A:
undetectable		 3ln1D-5jz8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 5 GLU A 403
GLY A 400
TYR A 405
ASP A 386
 None
 1.31A 3w9tD-5jz8A:
undetectable		 3w9tD-5jz8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 12 GLY A 461
GLY A 463
ASP A 469
ASN A 472
VAL A 476
 None
 0.98A 4fr0A-5jz8A:
undetectable		 4fr0A-5jz8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ASP A 523
LEU A 549
GLY A 550
 None
 0.50A 4xmfA-5jz8A:
undetectable		 4xmfA-5jz8A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 8 GLY A 438
GLN A 444
LEU A 440
THR A 442
 None
 1.00A 5syjA-5jz8A:
undetectable		 5syjA-5jz8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 ASP A 720
HIS A 725
THR A 680
GLY A 681
GLU A 617
 None
MN  A 801 ( 3.4A)
None
None
None
 1.36A 6mb5A-5jz8A:
undetectable		 6mb5A-5jz8A:
11.19