SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 124
LEU A  62
LEU A  42
GLY A 112
ALA A  70
 None
 1.09A 1b02A-5jzbA:
undetectable		 1b02A-5jzbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 135
ASN A  58
ILE A 284
ASN A 280
 None
 0.92A 1e06A-5jzbA:
undetectable		 1e06A-5jzbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 249
VAL A 251
TRP A 223
 None
 0.96A 1gmkA-5jzbA:
undetectable
1gmkB-5jzbA:
undetectable		 1gmkA-5jzbA:
5.31
1gmkB-5jzbA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  26
PHE A  88
GLY A  75
GLY A 116
LEU A  42
 None
 1.13A 1igxA-5jzbA:
undetectable		 1igxA-5jzbA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 SER A  79
VAL A  18
LEU A  24
 None
 0.70A 1yajG-5jzbA:
12.3		 1yajG-5jzbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 169
ILE A 184
MET A 177
 None
None
6OT  A 301 ( 4.9A)
 0.82A 2h42C-5jzbA:
undetectable		 2h42C-5jzbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A  88
GLY A  44
ASN A 113
PHE A  55
TYR A  76
 None
 1.41A 2piwA-5jzbA:
undetectable		 2piwA-5jzbA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 228
ARG A 230
PRO A 128
 None
 1.04A 2wljA-5jzbA:
undetectable		 2wljA-5jzbA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  55
ASN A  58
PHE A 279
 None
 1.04A 2zbuD-5jzbA:
2.8		 2zbuD-5jzbA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  62
PHE A  66
PHE A 286
GLY A 112
LEU A 136
 None
 1.34A 3tbgA-5jzbA:
undetectable		 3tbgA-5jzbA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  62
PHE A  66
PHE A 286
GLY A 112
LEU A 136
 None
 1.34A 3tbgC-5jzbA:
undetectable		 3tbgC-5jzbA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 11 HIS A  43
GLN A  73
GLY A 140
GLY A 141
MET A 222
 None
None
6OT  A 301 (-3.1A)
None
None
 1.34A 4fglA-5jzbA:
2.3
4fglB-5jzbA:
2.1		 4fglA-5jzbA:
21.55
4fglB-5jzbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 228
GLU A 218
TYR A 227
 None
 0.88A 4r29D-5jzbA:
undetectable		 4r29D-5jzbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 264
ILE A 236
LEU A 134
GLY A 138
ALA A 252
 None
 1.35A 5fctA-5jzbA:
undetectable		 5fctA-5jzbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 153
GLY A 154
ARG A 157
ASN A 113
LEU A 174
 PO4  A 302 ( 4.7A)
None
PO4  A 302 (-2.7A)
None
None
 1.34A 5fhzD-5jzbA:
3.3		 5fhzD-5jzbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 THR A  12
LEU A 103
VAL A 108
LEU A  96
 None
 1.02A 6bqgA-5jzbA:
undetectable		 6bqgA-5jzbA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
ASP A 101
SER A  79
LEU A  69
LEU A  42
 None
 1.19A 6ew0F-5jzbA:
2.9		 6ew0F-5jzbA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 112
LEU A  42
VAL A 243
PHE A 173
 None
 0.95A 6h7lA-5jzbA:
undetectable		 6h7lA-5jzbA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 112
LEU A  42
VAL A 243
PHE A 173
 None
 0.95A 6h7lB-5jzbA:
undetectable		 6h7lB-5jzbA:
15.67