SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		5 / 12 ILE A  78
LEU A 200
ASP A  47
GLY A  46
PHE A  53
 None
 1.12A 1hvyD-5jzdA:
undetectable		 1hvyD-5jzdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		9 / 11 GLU A 197
GLY A 214
GLU A 241
HIS A 276
LEU A 304
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 ( 4.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.48A 1i7qA-5jzdA:
36.1		 1i7qA-5jzdA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		8 / 10 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.45A 1i7qC-5jzdA:
24.5		 1i7qC-5jzdA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 6 SER A  25
PHE A  21
GLU A 341
GLY A 332
 None
 1.15A 1icuC-5jzdA:
undetectable
1icuD-5jzdA:
0.9		 1icuC-5jzdA:
22.62
1icuD-5jzdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		5 / 10 ALA A  77
ILE A  78
GLY A 328
CYH A 348
PHE A 181
 None
 1.41A 2b17A-5jzdA:
undetectable		 2b17A-5jzdA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		5 / 11 ARG A 347
VAL A 149
GLY A 363
LEU A 304
SER A 195
 ISC  A 401 (-3.5A)
None
ISC  A 401 (-3.3A)
ISC  A 401 ( 4.4A)
None
 1.07A 2bxeA-5jzdA:
undetectable		 2bxeA-5jzdA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		8 / 11 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.49A 2fn1A-5jzdA:
40.2		 2fn1A-5jzdA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		8 / 11 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.53A 2fn1B-5jzdA:
40.5		 2fn1B-5jzdA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		3 / 3 ARG A 206
GLU A 205
SER A  25
 None
 0.89A 2xctD-5jzdA:
1.2		 2xctD-5jzdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		7 / 12 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.48A 3r75A-5jzdA:
39.4		 3r75A-5jzdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		7 / 12 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.48A 3r75B-5jzdA:
39.2		 3r75B-5jzdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		7 / 11 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.45A 3r76A-5jzdA:
39.4		 3r76A-5jzdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		7 / 11 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.48A 3r76B-5jzdA:
39.3		 3r76B-5jzdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 7 LEU A 232
ASP A 238
SER A 215
HIS A 276
 None
None
ISC  A 401 (-2.7A)
ISC  A 401 (-3.5A)
 1.34A 4arcA-5jzdA:
undetectable		 4arcA-5jzdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		5 / 11 SER A  86
ILE A  78
LEU A 200
ASP A  47
GLY A  46
 None
 1.24A 4fogC-5jzdA:
undetectable		 4fogC-5jzdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 7 ILE A  78
ALA A  43
VAL A  44
ALA A 295
 None
 0.82A 4g77A-5jzdA:
undetectable		 4g77A-5jzdA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		5 / 12 LEU A 171
VAL A 387
ALA A 194
LEU A 191
LEU A 358
 None
 1.17A 4i1rA-5jzdA:
undetectable		 4i1rA-5jzdA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 7 GLY A 214
ASP A 238
GLY A 363
GLU A 373
 ISC  A 401 (-3.2A)
None
ISC  A 401 (-3.3A)
MG  A 402 ( 4.5A)
 0.91A 4koeA-5jzdA:
undetectable
4koeB-5jzdA:
1.3
4koeD-5jzdA:
undetectable		 4koeA-5jzdA:
22.68
4koeB-5jzdA:
22.68
4koeD-5jzdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		3 / 3 SER A  87
ALA A  77
THR A 345
 None
 0.69A 5n0xB-5jzdA:
undetectable		 5n0xB-5jzdA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 7 LEU A 232
VAL A 365
GLU A 373
SER A 368
 None
None
MG  A 402 ( 4.5A)
None
 1.27A 5umwA-5jzdA:
undetectable
5umwF-5jzdA:
undetectable		 5umwA-5jzdA:
12.03
5umwF-5jzdA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 8 PRO A 196
THR A 270
THR A 271
PRO A 280
 None
 1.34A 5x2sI-5jzdA:
undetectable
5x2sJ-5jzdA:
undetectable
5x2sK-5jzdA:
undetectable		 5x2sI-5jzdA:
17.75
5x2sJ-5jzdA:
18.75
5x2sK-5jzdA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5jzd ISOCHORISMATE
SYNTHASE ENTC
(Escherichia
coli) 		4 / 8 ASP A 187
ARG A 352
VAL A 331
GLN A 174
 None
 1.09A 6fbvD-5jzdA:
undetectable		 6fbvD-5jzdA:
15.83