SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5jze RNA-DEPENDENT RNA
POLYMERASE
(Thiafora
orthonairovirus) 		3 / 3 LEU A 158
PHE A  32
ARG A 140
 None
 0.83A 1xdkF-5jzeA:
undetectable		 1xdkF-5jzeA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5jze RNA-DEPENDENT RNA
POLYMERASE
(Thiafora
orthonairovirus) 		4 / 5 LEU A 106
LEU A  85
GLY A  86
GLY A  84
 None
 0.69A 3si7C-5jzeA:
undetectable
3si7D-5jzeA:
undetectable		 3si7C-5jzeA:
19.27
3si7D-5jzeA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jze RNA-DEPENDENT RNA
POLYMERASE
(Thiafora
orthonairovirus) 		4 / 4 LEU A   7
ARG A 161
ILE A 160
PHE A  32
 None
 1.28A 5kirB-5jzeA:
undetectable		 5kirB-5jzeA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5jze RNA-DEPENDENT RNA
POLYMERASE
(Thiafora
orthonairovirus) 		5 / 12 ARG A 161
ASN A  33
HIS A  29
PHE A  31
LEU A  28
 None
 1.44A 6a5kA-5jzeA:
undetectable		 6a5kA-5jzeA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5jze RNA-DEPENDENT RNA
POLYMERASE
(Thiafora
orthonairovirus) 		5 / 12 ARG A 161
ASN A  33
HIS A  29
PHE A  31
LEU A  28
 None
 1.43A 6a5mA-5jzeA:
undetectable		 6a5mA-5jzeA:
14.85