SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 GLY A 397
VAL A 404
ALA A 417
VAL A 449
VAL A 468
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.65A 1fmoE-5jznA:
25.3		 1fmoE-5jznA:
35.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
VAL A 449
VAL A 468
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.62A 1fmoE-5jznA:
25.3		 1fmoE-5jznA:
35.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 463
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.76A 1m17A-5jznA:
24.8		 1m17A-5jznA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 11 ASN A 435
ILE A 512
THR A 546
LEU A 440
VAL A 443
 None
None
SO4  A 702 (-3.3A)
None
None
 1.07A 1rv7A-5jznA:
undetectable
1rv7B-5jznA:
undetectable		 1rv7A-5jznA:
16.79
1rv7B-5jznA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		4 / 5 ILE A 624
TRP A 613
LEU A 628
PRO A 586
 None
 1.26A 1s8fA-5jznA:
undetectable
1s8fB-5jznA:
undetectable		 1s8fA-5jznA:
21.91
1s8fB-5jznA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 440
VAL A 449
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 1.06A 1t46A-5jznA:
21.9		 1t46A-5jznA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.82A 1uwhA-5jznA:
23.7		 1uwhA-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.82A 1uwhB-5jznA:
23.6		 1uwhB-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
 0.77A 1uwjA-5jznA:
7.1		 1uwjA-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ILE A 396
VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
 0.89A 1uwjB-5jznA:
7.1		 1uwjB-5jznA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
VAL A 449
VAL A 468
ASP A 472
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
None
GUI  A 701 (-4.0A)
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2eufB-5jznA:
27.4		 2eufB-5jznA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 LEU A 440
PHE A 534
LEU A 502
ILE A 507
TYR A 501
 None
 1.21A 2f78A-5jznA:
undetectable		 2f78A-5jznA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 LEU A 440
PHE A 534
LEU A 502
ILE A 507
TYR A 501
 None
 1.28A 2f78B-5jznA:
undetectable		 2f78B-5jznA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
VAL A 468
ASP A 511
LYS A 513
ASN A 516
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-4.0A)
None
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2fumA-5jznA:
22.3		 2fumA-5jznA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
MET A 465
VAL A 468
LYS A 513
ASN A 516
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.0A)
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2fumB-5jznA:
27.4		 2fumB-5jznA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.73A 2itoA-5jznA:
24.0		 2itoA-5jznA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 GLY A 397
VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.71A 2ityA-5jznA:
24.1		 2ityA-5jznA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 9 VAL A 404
ALA A 417
GLY A 471
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.65A 2xp2A-5jznA:
7.7		 2xp2A-5jznA:
26.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.40A 2y7jA-5jznA:
31.7		 2y7jA-5jznA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 10 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.46A 2y7jB-5jznA:
35.1		 2y7jB-5jznA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 10 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.48A 2y7jC-5jznA:
31.9		 2y7jC-5jznA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 10 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.55A 2y7jD-5jznA:
34.9		 2y7jD-5jznA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 10 ARG A 394
ALA A 417
LYS A 419
VAL A 449
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 3aoxA-5jznA:
22.5		 3aoxA-5jznA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LEU A 451
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.55A 3bbtB-5jznA:
22.1		 3bbtB-5jznA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 GLY A 397
GLU A 406
ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.55A 3c7qA-5jznA:
21.6		 3c7qA-5jznA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 440
LEU A 467
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
 0.76A 3hecA-5jznA:
23.4		 3hecA-5jznA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 8 ALA A 417
LYS A 419
GLU A 436
LEU A 463
LEU A 467
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
 0.61A 3lfaA-5jznA:
23.4		 3lfaA-5jznA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 11 ILE A 396
ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.80A 3miyA-5jznA:
23.3		 3miyA-5jznA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 ILE A 396
ALA A 417
LYS A 419
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.72A 3miyB-5jznA:
23.2		 3miyB-5jznA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 ILE A 396
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 0.68A 3ti1A-5jznA:
24.3		 3ti1A-5jznA:
32.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
LEU A 463
MET A 465
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.62A 3ug2A-5jznA:
23.7		 3ug2A-5jznA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LEU A 467
GLY A 471
ASP A 472
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.65A 3zbfA-5jznA:
24.4		 3zbfA-5jznA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
LYS A 419
GLU A 436
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.79A 4ag8A-5jznA:
21.9		 4ag8A-5jznA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 11 ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.53A 4agdA-5jznA:
21.3		 4agdA-5jznA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 440
GLY A 471
LEU A 502
HIS A 509
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
None
None
 0.97A 4asdA-5jznA:
21.8		 4asdA-5jznA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 GLY A 397
VAL A 404
ALA A 417
LEU A 463
MET A 465
GLY A 471
ASP A 475
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.75A 4i22A-5jznA:
22.1		 4i22A-5jznA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 GLY A 397
VAL A 404
ALA A 417
LYS A 419
LEU A 463
GLY A 471
ASP A 475
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 1.02A 4i22A-5jznA:
22.1		 4i22A-5jznA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 VAL A 404
ALA A 417
ASP A 472
ASP A 475
ASP A 511
LYS A 513
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.1A)
None
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.53A 4i41A-5jznA:
29.0		 4i41A-5jznA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 11 VAL A 404
ALA A 417
ASP A 472
GLU A 515
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.82A 4iaaA-5jznA:
28.8		 4iaaA-5jznA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 GLY A 397
VAL A 404
ALA A 417
LEU A 451
LEU A 463
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.58A 4ifgA-5jznA:
26.3		 4ifgA-5jznA:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 10 ILE A 396
ALA A 417
VAL A 449
MET A 465
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.46A 4ks8A-5jznA:
26.8		 4ks8A-5jznA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
GLU A 436
VAL A 449
MET A 465
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.68A 4mxyA-5jznA:
25.3		 4mxyA-5jznA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
GLU A 436
VAL A 449
MET A 465
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.68A 4mxzA-5jznA:
25.3		 4mxzA-5jznA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 9 VAL A 404
ALA A 417
ASP A 472
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.77A 4ogrI-5jznA:
26.5		 4ogrI-5jznA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
ALA A 417
GLU A 436
MET A 465
LEU A 518
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.78A 4qmnA-5jznA:
29.3		 4qmnA-5jznA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 11 ILE A 396
ALA A 417
GLU A 436
MET A 465
LEU A 518
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 4qmsA-5jznA:
29.4		 4qmsA-5jznA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
GLY A 397
VAL A 404
ALA A 417
MET A 465
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
 0.44A 4qmzA-5jznA:
29.0		 4qmzA-5jznA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 10 ILE A 396
ALA A 417
LEU A 467
VAL A 468
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
 0.57A 4rz7A-5jznA:
11.8		 4rz7A-5jznA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		4 / 6 ARG A 394
ALA A 417
MET A 465
LEU A 518
 None
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
 0.51A 4wboC-5jznA:
26.0		 4wboC-5jznA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
GLU A 436
LEU A 463
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.56A 4wkqA-5jznA:
24.5		 4wkqA-5jznA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.71A 4wkqA-5jznA:
24.5		 4wkqA-5jznA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LYS A 419
GLY A 532
ASP A 533
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
None
 0.90A 4xv2A-5jznA:
23.5		 4xv2A-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 ALA A 417
LYS A 419
GLY A 532
ASP A 533
PHE A 534
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
None
 0.80A 4xv2B-5jznA:
23.5		 4xv2B-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.79A 4xv2B-5jznA:
23.5		 4xv2B-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 9 VAL A 404
ALA A 417
GLY A 471
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.66A 5aaaA-5jznA:
23.2		 5aaaA-5jznA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.84A 5cswA-5jznA:
23.3		 5cswA-5jznA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.81A 5cswB-5jznA:
23.4		 5cswB-5jznA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 8 GLU A 557
GLY A 565
VAL A 632
ASP A 569
HIS A 503
 None
 1.41A 5f8yA-5jznA:
undetectable		 5f8yA-5jznA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ARG A 394
ALA A 417
LYS A 419
GLY A 471
LEU A 518
GLY A 532
 None
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
 0.84A 5h2uC-5jznA:
22.5		 5h2uC-5jznA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
GLY A 532
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
 0.60A 5h2uD-5jznA:
22.7		 5h2uD-5jznA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.85A 5hi2A-5jznA:
23.9		 5hi2A-5jznA:
27.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 GLY A 397
VAL A 404
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 0.63A 5l2iA-5jznA:
7.9		 5l2iA-5jznA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ILE A 396
GLY A 397
VAL A 404
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 1.14A 5l2tA-5jznA:
8.0		 5l2tA-5jznA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 GLY A 397
VAL A 404
ALA A 417
MET A 465
LEU A 467
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 ( 4.7A)
 0.66A 5lw1H-5jznA:
19.6		 5lw1H-5jznA:
14.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 10 VAL A 404
ALA A 417
VAL A 449
MET A 465
VAL A 468
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
 0.55A 5n3hA-5jznA:
29.3		 5n3hA-5jznA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
GLY A 397
ALA A 417
GLU A 436
GLY A 471
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.8A)
 0.83A 5vc3A-5jznA:
28.1		 5vc3A-5jznA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
VAL A 449
LEU A 463
GLY A 471
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.7A)
 1.07A 5vcvA-5jznA:
23.5		 5vcvA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		4 / 4 VAL A 449
LEU A 467
ASN A 516
ASP A 533
 None
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.84A 5vcyA-5jznA:
27.5		 5vcyA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ARG A 394
VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 5y7zA-5jznA:
26.1		 5y7zA-5jznA:
14.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ARG A 394
VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 5y7zA-5jznA:
26.1		 5y7zA-5jznA:
32.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
GLU A 436
LEU A 463
LEU A 467
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.70A 5y7zB-5jznA:
26.1		 5y7zB-5jznA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.58A 5y80A-5jznA:
25.1		 5y80A-5jznA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 GLY A 397
VAL A 404
ALA A 417
LEU A 463
ASP A 475
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.61A 5yu9B-5jznA:
22.4		 5yu9B-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 VAL A 404
ALA A 417
LEU A 463
GLY A 471
ASP A 475
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
 0.53A 5yu9C-5jznA:
21.9		 5yu9C-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 VAL A 404
ALA A 417
LYS A 419
LEU A 463
GLY A 471
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
 0.73A 5yu9C-5jznA:
21.9		 5yu9C-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 LEU A 581
VAL A 616
SER A 619
PHE A 608
VAL A 606
 None
 1.37A 6a94A-5jznA:
undetectable		 6a94A-5jznA:
20.95