SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens) 		4 / 8 VAL A  34
TYR A  78
ASP A  82
LEU A  65
 None
 1.19A 1pk2A-5jzvA:
undetectable		 1pk2A-5jzvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens) 		6 / 12 PRO A  12
LYS A  16
THR A  17
ASN A  33
GLY A  35
ARG A  39
 ADP  A 201 ( 4.9A)
ADP  A 201 (-2.8A)
ADP  A 201 (-4.3A)
None
None
None
 0.76A 2axnA-5jzvA:
9.0		 2axnA-5jzvA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens) 		4 / 5 SER A 135
ARG A  96
GLY A  10
GLU A 123
 None
 1.19A 3k9fA-5jzvA:
undetectable
3k9fB-5jzvA:
undetectable
3k9fC-5jzvA:
undetectable		 3k9fA-5jzvA:
17.10
3k9fB-5jzvA:
17.10
3k9fC-5jzvA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens) 		4 / 6 SER A 135
ARG A  96
GLY A  10
GLU A 123
 None
 1.09A 5btcA-5jzvA:
undetectable
5btcC-5jzvA:
undetectable
5btcD-5jzvA:
undetectable		 5btcA-5jzvA:
18.30
5btcC-5jzvA:
18.30
5btcD-5jzvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens) 		4 / 4 VAL A  14
GLU A 123
GLY A  10
LEU A  95
 ADP  A 201 (-4.2A)
None
None
None
 1.21A 5g5gC-5jzvA:
undetectable		 5g5gC-5jzvA:
13.10