SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 124
SER A 125
ASP A 107
PHE A 197
 None
 0.98A 1ismB-5jzxA:
undetectable		 1ismB-5jzxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 175
ARG A 176
GLU A 361
SER A 257
 None
FAD  A 401 (-3.9A)
K  A 402 (-4.2A)
None
 1.28A 2zt7A-5jzxA:
undetectable		 2zt7A-5jzxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 109
ILE A 150
VAL A 153
VAL A 192
 None
None
None
FAD  A 401 (-3.7A)
 0.76A 3fi0B-5jzxA:
undetectable		 3fi0B-5jzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 109
ILE A 150
VAL A 153
VAL A 192
 None
None
None
FAD  A 401 (-3.7A)
 0.76A 3fi0G-5jzxA:
undetectable		 3fi0G-5jzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 GLN A 137
VAL A 139
ILE A 150
VAL A 195
VAL A 192
 None
FAD  A 401 (-3.1A)
None
None
FAD  A 401 (-3.7A)
 1.28A 3fi0M-5jzxA:
undetectable		 3fi0M-5jzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 GLN A 137
VAL A 139
ILE A 150
VAL A 195
VAL A 192
 None
FAD  A 401 (-3.1A)
None
None
FAD  A 401 (-3.7A)
 1.31A 3fi0O-5jzxA:
undetectable		 3fi0O-5jzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 109
ILE A 150
VAL A 153
VAL A 192
 None
None
None
FAD  A 401 (-3.7A)
 0.73A 3fi0Q-5jzxA:
undetectable		 3fi0Q-5jzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 325
LEU A 342
VAL A 346
LEU A 369
PHE A 259
 None
 1.16A 3jw5B-5jzxA:
undetectable		 3jw5B-5jzxA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  42
GLY A 132
GLY A 103
GLU A 194
VAL A 192
 None
FAD  A 401 ( 4.0A)
None
None
FAD  A 401 (-3.7A)
 1.02A 3o7wA-5jzxA:
undetectable		 3o7wA-5jzxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  30
SER A 254
GLU A 337
ALA A 334
ASN A 330
 None
FAD  A 401 (-3.6A)
None
None
None
 1.44A 3t7sC-5jzxA:
undetectable		 3t7sC-5jzxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  74
GLY A 185
VAL A 191
PRO A  63
LEU A  49
 None
FAD  A 401 (-4.0A)
FAD  A 401 (-3.7A)
None
None
 1.07A 3v8vA-5jzxA:
undetectable		 3v8vA-5jzxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  93
GLN A 116
ILE A 114
GLU A 122
 None
 1.22A 4a99D-5jzxA:
undetectable		 4a99D-5jzxA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 133
GLY A  69
GLY A  68
THR A  26
LEU A  27
 FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
FAD  A 401 (-3.2A)
FAD  A 401 (-3.8A)
None
 0.96A 4n49A-5jzxA:
undetectable		 4n49A-5jzxA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  67
GLY A  68
GLY A  69
ASN A  71
GLY A 132
 FAD  A 401 (-3.3A)
FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
FAD  A 401 ( 3.6A)
FAD  A 401 ( 4.0A)
 1.03A 4obwB-5jzxA:
undetectable		 4obwB-5jzxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 233
ALA A 229
ALA A 225
SER A 205
ALA A 216
 None
 1.31A 4twdA-5jzxA:
undetectable
4twdB-5jzxA:
undetectable
4twdC-5jzxA:
undetectable
4twdD-5jzxA:
undetectable
4twdE-5jzxA:
undetectable		 4twdA-5jzxA:
22.01
4twdB-5jzxA:
22.01
4twdC-5jzxA:
22.01
4twdD-5jzxA:
22.01
4twdE-5jzxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 296
ASN A 261
PRO A 262
GLU A 361
TYR A 175
 None
None
None
K  A 402 (-4.2A)
None
 1.45A 4xqeA-5jzxA:
undetectable		 4xqeA-5jzxA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 296
ASN A 261
PRO A 262
GLU A 361
TYR A 175
 None
None
None
K  A 402 (-4.2A)
None
 1.45A 4xqeB-5jzxA:
undetectable		 4xqeB-5jzxA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 296
ASN A 261
PRO A 262
GLU A 361
TYR A 175
 None
None
None
K  A 402 (-4.2A)
None
 1.38A 4xrgB-5jzxA:
undetectable		 4xrgB-5jzxA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 129
ALA A 100
ILE A  91
LEU A 121
ILE A 127
 FAD  A 401 (-3.4A)
None
None
None
FAD  A 401 (-4.1A)
 1.16A 4xumB-5jzxA:
undetectable		 4xumB-5jzxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 354
LEU A 358
ASN A 261
PRO A 262
 None
 1.32A 4yv5B-5jzxA:
undetectable		 4yv5B-5jzxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 354
LEU A 358
ASN A 261
PRO A 262
 None
 1.33A 4yv5A-5jzxA:
undetectable		 4yv5A-5jzxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  76
GLY A  30
LEU A  24
VAL A  83
VAL A  36
 None
 1.10A 5dpdA-5jzxA:
undetectable		 5dpdA-5jzxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 245
THR A  26
PRO A 128
LEU A  72
 None
FAD  A 401 (-3.8A)
FAD  A 401 (-3.7A)
FAD  A 401 (-3.9A)
 0.97A 5fxtA-5jzxA:
undetectable		 5fxtA-5jzxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  67
ILE A 365
LEU A  64
ILE A  74
ALA A 133
 FAD  A 401 (-3.3A)
None
None
None
FAD  A 401 (-3.2A)
 0.96A 5nunA-5jzxA:
undetectable		 5nunA-5jzxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  83
PRO A 360
VAL A 339
PHE A  66
PHE A 258
 None
 1.47A 6becA-5jzxA:
undetectable
6becB-5jzxA:
undetectable
6becC-5jzxA:
undetectable		 6becA-5jzxA:
22.28
6becB-5jzxA:
22.28
6becC-5jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 144
ALA A 206
VAL A 230
SER A 205
GLY A 119
 None
 1.20A 6bklA-5jzxA:
undetectable
6bklB-5jzxA:
undetectable
6bklC-5jzxA:
undetectable
6bklD-5jzxA:
undetectable		 6bklA-5jzxA:
6.80
6bklB-5jzxA:
6.80
6bklC-5jzxA:
6.80
6bklD-5jzxA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 SER A  70
GLY A 103
GLY A 132
LEU A 193
VAL A 192
 FAD  A 401 (-2.4A)
None
FAD  A 401 ( 4.0A)
None
FAD  A 401 (-3.7A)
 1.22A 6i5zD-5jzxA:
undetectable		 6i5zD-5jzxA:
22.35