SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		5 / 12 GLY A  22
GLY A 262
ASP A 264
HIS A 291
PHE A 293
 None
 0.58A 1ffyA-5k0tA:
24.4		 1ffyA-5k0tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		5 / 12 HIS A  23
GLY A  22
GLY A 262
ASP A 264
HIS A 291
 None
 1.21A 1ffyA-5k0tA:
24.4		 1ffyA-5k0tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 PHE A 289
PHE A 333
ALA A 290
ILE A 261
 None
 1.01A 1fxhA-5k0tA:
undetectable
1fxhB-5k0tA:
undetectable		 1fxhA-5k0tA:
17.89
1fxhB-5k0tA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		8 / 11 ALA A  11
GLY A  22
HIS A  23
GLU A  26
GLY A 262
ASP A 264
ILE A 265
HIS A 291
 415  A 601 ( 4.0A)
None
None
None
None
None
415  A 601 ( 4.0A)
None
 0.44A 1pg2A-5k0tA:
40.6		 1pg2A-5k0tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		6 / 12 GLY A  22
HIS A  23
GLY A 262
ASP A 264
HIS A 291
PHE A 293
 None
 0.55A 1qu2A-5k0tA:
24.4		 1qu2A-5k0tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		5 / 12 GLY A  22
HIS A  23
ASP A 264
HIS A 291
PHE A 293
 None
 0.66A 1qu3A-5k0tA:
28.6		 1qu3A-5k0tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		3 / 3 ALA A 111
VAL A 113
TRP A 109
 None
 0.95A 1w5uA-5k0tA:
undetectable
1w5uB-5k0tA:
undetectable		 1w5uA-5k0tA:
5.42
1w5uB-5k0tA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		3 / 3 TRP A 109
ALA A 111
VAL A 113
 None
 0.94A 2izqC-5k0tA:
undetectable
2izqD-5k0tA:
undetectable		 2izqC-5k0tA:
5.42
2izqD-5k0tA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 6 LEU A 475
ILE A 367
VAL A 375
ALA A 450
 None
 0.98A 2j5mA-5k0tA:
undetectable		 2j5mA-5k0tA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		9 / 11 ALA A  11
ALA A  13
GLY A  22
HIS A  23
GLU A  26
GLY A 262
ASP A 264
ILE A 265
HIS A 291
 415  A 601 ( 4.0A)
None
None
None
None
None
None
415  A 601 ( 4.0A)
None
 0.44A 2x1lA-5k0tA:
50.4		 2x1lA-5k0tA:
61.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		10 / 12 ALA A  11
ALA A  13
GLY A  22
HIS A  23
GLU A  26
GLY A 262
ASP A 264
ILE A 265
HIS A 291
LEU A 294
 415  A 601 ( 4.0A)
None
None
None
None
None
None
415  A 601 ( 4.0A)
None
None
 0.54A 2x1lB-5k0tA:
53.8		 2x1lB-5k0tA:
61.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		9 / 11 ALA A  11
ALA A  13
GLY A  22
HIS A  23
GLU A  26
GLY A 262
ASP A 264
ILE A 265
HIS A 291
 415  A 601 ( 4.0A)
None
None
None
None
None
None
415  A 601 ( 4.0A)
None
 0.35A 2x1lC-5k0tA:
53.5		 2x1lC-5k0tA:
61.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 ILE A 415
LEU A 412
ARG A 400
MET A 403
 None
 0.92A 3ablA-5k0tA:
undetectable
3ablJ-5k0tA:
undetectable		 3ablA-5k0tA:
21.60
3ablJ-5k0tA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 ILE A  28
GLY A  22
VAL A 331
LEU A 314
 None
 0.92A 3elzA-5k0tA:
undetectable		 3elzA-5k0tA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		5 / 12 GLN A  37
ILE A 415
VAL A 460
ILE A 458
ALA A 399
 None
 0.98A 3fpjA-5k0tA:
undetectable		 3fpjA-5k0tA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		3 / 3 TRP A 109
ALA A 111
VAL A 113
 None
 0.98A 3l8lC-5k0tA:
undetectable
3l8lD-5k0tA:
undetectable		 3l8lC-5k0tA:
5.42
3l8lD-5k0tA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 5 HIS A 101
SER A  97
ASP A  92
THR A 239
 None
 1.33A 3okxB-5k0tA:
undetectable		 3okxB-5k0tA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 6 ILE A 415
LEU A 412
ARG A 400
MET A 403
 None
 1.14A 3wg7A-5k0tA:
undetectable
3wg7J-5k0tA:
undetectable		 3wg7A-5k0tA:
21.60
3wg7J-5k0tA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		5 / 12 GLY A 242
ILE A  94
HIS A 101
LEU A 241
THR A 235
 None
 1.36A 4pooA-5k0tA:
2.5		 4pooA-5k0tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 ILE A 415
LEU A 412
ARG A 400
MET A 403
 None
 0.97A 5b1bA-5k0tA:
undetectable
5b1bJ-5k0tA:
undetectable		 5b1bA-5k0tA:
21.60
5b1bJ-5k0tA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 6 PHE A 312
HIS A  23
PRO A  19
MET A  82
 None
 1.32A 5dzka-5k0tA:
undetectable
5dzko-5k0tA:
undetectable		 5dzka-5k0tA:
19.49
5dzko-5k0tA:
1.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 THR A  96
ASP A  51
ASP A 232
GLY A  54
 None
415  A 601 (-3.1A)
415  A 601 ( 4.6A)
415  A 601 (-3.5A)
 0.93A 5hwaA-5k0tA:
undetectable		 5hwaA-5k0tA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 ILE A 415
LEU A 412
ARG A 400
MET A 403
 None
 0.96A 5iy5A-5k0tA:
0.3
5iy5J-5k0tA:
undetectable		 5iy5A-5k0tA:
21.60
5iy5J-5k0tA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 7 PHE A 165
ALA A 124
GLY A 125
TYR A 127
 None
 0.90A 5uxdA-5k0tA:
2.0		 5uxdA-5k0tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		3 / 3 GLY A 221
TRP A 109
VAL A 113
 None
 0.76A 5vuoB-5k0tA:
undetectable		 5vuoB-5k0tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 5k0t METHIONINE--TRNA
LIGASE
(Brucella
suis) 		4 / 6 TYR A   7
THR A  48
TYR A 237
THR A  30
 None
 1.06A 6cnkA-5k0tA:
4.2
6cnkB-5k0tA:
4.5		 6cnkA-5k0tA:
9.42
6cnkB-5k0tA:
9.42