SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Rhinovirus
C;
Rhinovirus
C) 		3 / 3 GLU B  79
ILE B  81
ARG A 273
 None
 0.81A 1cd2A-5k0uB:
undetectable		 1cd2A-5k0uB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 6 HIS C  99
GLY C 258
TYR C  98
GLU C 261
 None
 0.97A 1dmaB-5k0uC:
undetectable		 1dmaB-5k0uC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 8 TYR A 185
THR C 147
THR A 248
ASP A 183
 None
 0.93A 1dz9A-5k0uA:
undetectable		 1dz9A-5k0uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 7 GLY C 136
ALA C 133
THR A 243
SER A 247
 None
 0.90A 1gtfL-5k0uC:
1.5
1gtfM-5k0uC:
0.7		 1gtfL-5k0uC:
13.78
1gtfM-5k0uC:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Rhinovirus
C) 		3 / 4 LYS A 104
ALA A 100
MET B 228
 None
 1.00A 1hk3A-5k0uA:
undetectable		 1hk3A-5k0uA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 5 TYR C 144
TYR A 185
PRO A 188
ASP A 186
 None
 1.50A 1i7zB-5k0uC:
1.3		 1i7zB-5k0uC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 8 TYR A 185
THR C 147
THR A 248
ASP A 183
 None
 0.95A 1o76B-5k0uA:
undetectable		 1o76B-5k0uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 6 LEU B  25
VAL A 121
ILE A 130
MET A 204
 None
 1.15A 2hyyC-5k0uB:
undetectable		 2hyyC-5k0uB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 7 ILE B 112
LEU B 102
GLY B  99
PHE B  93
 None
 0.86A 2tsrA-5k0uB:
undetectable		 2tsrA-5k0uB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 5 PHE A 114
PHE A 181
PHE A 106
ILE C 188
 None
 1.39A 2v0mD-5k0uA:
undetectable		 2v0mD-5k0uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Rhinovirus
C;
Rhinovirus
C) 		4 / 5 PHE A 171
PHE B  28
LEU B  25
PHE A 132
 None
 1.32A 3abmP-5k0uA:
undetectable
3abmW-5k0uA:
undetectable		 3abmP-5k0uA:
21.31
3abmW-5k0uA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		3 / 3 PHE C  92
GLN C 263
PHE C 106
 None
 0.84A 3rv5A-5k0uC:
undetectable		 3rv5A-5k0uC:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5k0u CAPSID PROTEIN VP3
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 5 LEU B 156
GLY B 126
PHE B 196
ARG C 197
 None
 1.04A 3smtA-5k0uB:
undetectable		 3smtA-5k0uB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5k0u CAPSID PROTEIN VP2
CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 5 LEU C 183
GLY C 184
MET B  67
PHE C 176
 None
 1.31A 3uq6B-5k0uC:
undetectable		 3uq6B-5k0uC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 7 ASP C 171
ARG C 157
HIS C 154
HIS A 251
 None
 1.42A 3zodA-5k0uC:
undetectable		 3zodA-5k0uC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 5 MET C  96
LEU C 218
PRO C 251
SER C 104
 None
 1.48A 4kmmB-5k0uC:
undetectable		 4kmmB-5k0uC:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 8 HIS B 184
ASP B 180
ARG B 176
ARG B 175
 None
 1.21A 4uhxA-5k0uB:
undetectable		 4uhxA-5k0uB:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		3 / 3 ALA C 250
TYR C  64
PRO C  56
 None
 0.62A 4zdyA-5k0uC:
undetectable		 4zdyA-5k0uC:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 4 VAL A 233
ILE C 127
ASN C 222
VAL C 206
 None
 1.21A 5ajqA-5k0uA:
undetectable		 5ajqA-5k0uA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		5 / 11 ALA B 209
VAL B 130
LEU B  82
LEU B  92
VAL B 188
 None
 0.98A 5eb5A-5k0uB:
undetectable		 5eb5A-5k0uB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 8 THR A 243
SER A 247
GLY C 136
ALA C 133
 None
 0.90A 5eevL-5k0uA:
1.6
5eevV-5k0uA:
undetectable		 5eevL-5k0uA:
15.02
5eevV-5k0uA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 8 THR A 243
SER A 247
GLY C 136
ALA C 133
 None
 0.90A 5eewL-5k0uA:
1.6
5eewV-5k0uA:
undetectable		 5eewL-5k0uA:
15.02
5eewV-5k0uA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 8 THR A 243
SER A 247
GLY C 136
ALA C 133
 None
 0.90A 5ef3L-5k0uA:
1.6
5ef3V-5k0uA:
1.6		 5ef3L-5k0uA:
15.02
5ef3V-5k0uA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		5 / 12 ASP C  84
ALA C  85
ASP C  61
GLY C 105
TYR C 208
 None
 1.36A 5hfjA-5k0uC:
undetectable		 5hfjA-5k0uC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 7 LEU C  82
ILE C 245
THR C 110
TRP C  78
 None
 1.24A 5ljcA-5k0uC:
undetectable		 5ljcA-5k0uC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 8 PRO C 190
ILE C 209
VAL A 233
ILE C 127
 None
 0.92A 5mzrE-5k0uC:
undetectable		 5mzrE-5k0uC:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 7 ILE B 112
LEU B 102
GLY B  99
PHE B  93
 None
 0.86A 5nooA-5k0uB:
undetectable		 5nooA-5k0uB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 7 ILE B 112
LEU B 102
GLY B  99
PHE B  93
 None
 0.88A 5nooB-5k0uB:
undetectable		 5nooB-5k0uB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O45_B_CCSB13_0
(PHE-MEA-9KK-SAR-ASP-
VAL-MEA-TYR-SAR-TRP-
TYR-LEU-CCS-GLY-NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		5 / 9 GLU C 129
ASP A 183
ASN C 222
TYR A 179
GLY A 184
 None
 1.41A 5o45A-5k0uC:
0.0
5o45B-5k0uC:
undetectable		 5o45A-5k0uC:
17.54
5o45B-5k0uC:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5k0u CAPSID PROTEIN VP1
(Rhinovirus
C) 		3 / 3 GLY A 205
VAL A 118
MET A 116
 None
 0.66A 5ycpA-5k0uA:
undetectable		 5ycpA-5k0uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5k0u CAPSID PROTEIN VP2
(Rhinovirus
C) 		5 / 9 ILE C 227
SER C 152
SER C  75
GLY C  77
THR C 110
 None
 1.50A 6awpA-5k0uC:
undetectable		 6awpA-5k0uC:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		4 / 7 VAL B  72
PRO B  85
PHE B 116
LEU B  84
 None
 1.16A 6aycA-5k0uB:
undetectable		 6aycA-5k0uB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5k0u CAPSID PROTEIN VP1
(Rhinovirus
C) 		5 / 12 GLU A  71
PRO A 226
PHE A 106
PRO A 234
PHE A 108
 None
 1.18A 6becA-5k0uA:
3.8
6becB-5k0uA:
2.9
6becC-5k0uA:
3.5		 6becA-5k0uA:
19.57
6becB-5k0uA:
19.57
6becC-5k0uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C) 		4 / 8 GLY A  43
GLN C 192
SER A  45
TYR C  35
 None
 0.95A 6eqpA-5k0uA:
undetectable		 6eqpA-5k0uA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Rhinovirus
C;
Rhinovirus
C) 		4 / 6 ASP C 215
TYR A 179
GLU C 129
ASP A 183
 None
 1.03A 6mn5C-5k0uC:
undetectable		 6mn5C-5k0uC:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5k0u CAPSID PROTEIN VP3
(Rhinovirus
C) 		5 / 12 LEU B  84
ILE B  53
LEU B  98
GLY B  99
PHE B  93
 None
 1.08A 6qxsB-5k0uB:
undetectable		 6qxsB-5k0uB:
20.12