SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 12 GLY A  42
ASN A  43
ASP A 235
ASP A 264
PHE A 245
 None
 1.44A 2b9eA-5k0wA:
undetectable		 2b9eA-5k0wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 7 TYR A 193
TYR A 257
GLN A 260
PHE A 262
 None
 1.35A 2qmqA-5k0wA:
undetectable		 2qmqA-5k0wA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 12 ASP A 124
GLY A 178
VAL A 127
SER A 240
HIS A 241
 None
None
None
None
ZN  A 301 (-3.3A)
 1.24A 3d91B-5k0wA:
undetectable		 3d91B-5k0wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 5 PRO A 150
THR A 144
VAL A 143
GLY A 132
 None
 1.07A 3elzA-5k0wA:
0.7		 3elzA-5k0wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		3 / 3 TYR A 215
ASP A 135
ASP A 126
 None
 0.89A 3ou7B-5k0wA:
undetectable		 3ou7B-5k0wA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 7 GLN A  98
HIS A 103
GLU A  72
PRO A  28
 ZN  A 302 ( 2.6A)
ZN  A 301 (-3.3A)
None
None
 1.39A 3ql6A-5k0wA:
undetectable		 3ql6A-5k0wA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 9 ALA A 106
GLY A  69
LEU A  52
ASN A  67
ILE A  76
 None
 1.40A 3wdmA-5k0wA:
undetectable		 3wdmA-5k0wA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 12 LEU A  94
LEU A  56
ILE A  77
ILE A  91
PHE A  86
 None
 1.43A 4a79A-5k0wA:
undetectable		 4a79A-5k0wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 12 LEU A  94
LEU A  56
ILE A  77
ILE A  91
PHE A  86
 None
 1.42A 4a79B-5k0wA:
undetectable		 4a79B-5k0wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 11 LEU A  94
LEU A  56
ILE A  77
ILE A  91
PHE A  86
 None
 1.40A 4a7aA-5k0wA:
undetectable		 4a7aA-5k0wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 6 HIS A 241
HIS A 175
SER A 202
ASP A 264
 ZN  A 301 (-3.3A)
ZN  A 302 (-3.3A)
None
None
 1.30A 4blvA-5k0wA:
undetectable		 4blvA-5k0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 8 VAL A  47
TYR A  35
TYR A  46
ILE A  76
 None
 1.22A 4bqtC-5k0wA:
undetectable
4bqtD-5k0wA:
undetectable		 4bqtC-5k0wA:
20.98
4bqtD-5k0wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 7 THR A 144
THR A 176
LEU A  96
SER A 134
 None
 0.98A 4pfjA-5k0wA:
undetectable		 4pfjA-5k0wA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 8 HIS A 100
ASP A 102
HIS A 175
HIS A 241
 ZN  A 302 (-3.2A)
ZN  A 301 (-2.6A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.3A)
 0.71A 5a5zA-5k0wA:
16.5		 5a5zA-5k0wA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		3 / 3 TYR A 101
THR A 104
THR A 144
 None
 0.74A 5aoxB-5k0wA:
undetectable		 5aoxB-5k0wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		3 / 3 TYR A 101
THR A 104
THR A 144
 None
 0.76A 5aoxE-5k0wA:
undetectable		 5aoxE-5k0wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		5 / 11 HIS A 100
ASP A 102
HIS A 103
HIS A 175
HIS A 241
 ZN  A 302 (-3.2A)
ZN  A 301 (-2.6A)
ZN  A 301 (-3.3A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.3A)
 0.18A 5ayaA-5k0wA:
32.4		 5ayaA-5k0wA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		3 / 3 VAL A 120
GLN A  98
CYH A 180
 None
ZN  A 302 ( 2.6A)
None
 0.63A 5icxC-5k0wA:
undetectable
5icxF-5k0wA:
undetectable		 5icxC-5k0wA:
19.39
5icxF-5k0wA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 8 HIS A 100
ASP A 102
HIS A 175
HIS A 241
 ZN  A 302 (-3.2A)
ZN  A 301 (-2.6A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.3A)
 0.78A 5zj8A-5k0wA:
16.4		 5zj8A-5k0wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5k0w CLASS B
CARBAPENEMASE GOB-18
(Elizabethkingia
meningoseptica) 		4 / 5 THR A 144
THR A 176
HIS A 175
GLY A  69
 None
None
ZN  A 302 (-3.3A)
None
 1.06A 6gbnC-5k0wA:
undetectable		 6gbnC-5k0wA:
20.59