SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 6 TRP T  56
GLY T  53
ASN T  74
PRO T  32
 None
 1.48A 1dedA-5k0yT:
undetectable		 1dedA-5k0yT:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Oryctolagus
cuniculus) 		3 / 3 THR P 220
PRO P 224
THR P 222
 None
 0.94A 1dscC-5k0yP:
undetectable		 1dscC-5k0yP:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 6 CYH S 361
ASP S 276
VAL S 291
GLY S 289
 None
None
A  N  75 ( 4.5A)
None
 1.24A 1ekjC-5k0yS:
undetectable
1ekjD-5k0yS:
undetectable		 1ekjC-5k0yS:
22.52
1ekjD-5k0yS:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 6 CYH S 361
ASP S 276
VAL S 291
GLY S 289
 None
None
A  N  75 ( 4.5A)
None
 1.25A 1ekjC-5k0yS:
undetectable
1ekjD-5k0yS:
undetectable		 1ekjC-5k0yS:
22.52
1ekjD-5k0yS:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Oryctolagus
cuniculus) 		3 / 3 THR P 222
THR P 220
PRO P 224
 None
 0.88A 1fjaC-5k0yP:
undetectable		 1fjaC-5k0yP:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Oryctolagus
cuniculus) 		3 / 3 THR P 222
THR P 220
PRO P 224
 None
 0.87A 1fjaD-5k0yP:
undetectable		 1fjaD-5k0yP:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5k0y RIBOSOMAL PROTEIN
ES17
(Oryctolagus
cuniculus) 		5 / 11 ILE e  16
ALA e  13
VAL e  54
MET e  58
ARG e  60
 None
None
None
None
C  A1460 ( 3.6A)
 1.11A 1n4hA-5k0ye:
undetectable		 1n4hA-5k0ye:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 293
ALA S 292
ILE S 307
ILE S 270
PRO S 311
 None
 1.02A 1sguB-5k0yS:
undetectable		 1sguB-5k0yS:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 6 LEU S 384
GLU S 379
LEU S 442
VAL S 370
 None
 0.82A 1sn5A-5k0yS:
undetectable		 1sn5A-5k0yS:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 8 LEU S 384
GLU S 379
LEU S 442
VAL S 370
 None
 0.83A 1sn5C-5k0yS:
undetectable		 1sn5C-5k0yS:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 10 VAL S 419
LYS S 453
GLY S 470
LEU S 456
ILE S 472
 None
 1.45A 1sq5D-5k0yS:
undetectable		 1sq5D-5k0yS:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 11 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.90A 2fxeB-5k0yS:
undetectable		 2fxeB-5k0yS:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 4 LEU S 417
ILE S 386
ILE S 454
ALA S 455
 None
 0.88A 2i30A-5k0yS:
undetectable		 2i30A-5k0yS:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Oryctolagus
cuniculus) 		3 / 3 ARG P 244
VAL P 250
THR P 239
 None
 0.76A 2nmzA-5k0yP:
undetectable		 2nmzA-5k0yP:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 5 VAL T  28
THR T  27
VAL T 309
GLY T 303
 None
 1.13A 2p2fA-5k0yT:
undetectable		 2p2fA-5k0yT:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 4 VAL T  28
THR T  27
VAL T 309
GLY T 303
 None
 1.12A 2p2fB-5k0yT:
undetectable		 2p2fB-5k0yT:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT G
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 7 ALA T 267
TYR T 300
MET M 128
HIS T 284
 None
 1.39A 2pncA-5k0yT:
undetectable		 2pncA-5k0yT:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		3 / 3 ARG S 398
GLN S 219
PRO S 179
 None
 0.85A 2qhfA-5k0yS:
undetectable		 2qhfA-5k0yS:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 9 GLU T 233
ILE T  13
GLY T 304
GLY T 286
LEU T 234
 None
 1.18A 2qmmA-5k0yT:
undetectable		 2qmmA-5k0yT:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5k0y RIBOSOMAL PROTEIN S9
(PREDICTED)
(Oryctolagus
cuniculus) 		4 / 6 LEU K  81
LEU K  77
ILE K  84
ARG K  83
 None
None
None
U  A 816 ( 3.4A)
 1.17A 2rlfB-5k0yK:
undetectable
2rlfC-5k0yK:
undetectable		 2rlfB-5k0yK:
13.41
2rlfC-5k0yK:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 9 ALA T 235
VAL T 246
GLY T 247
GLY T 248
ALA T 212
 None
 0.94A 2z0yA-5k0yT:
undetectable		 2z0yA-5k0yT:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S  58
ALA S 168
ILE S 200
ALA S 189
ILE S 190
 None
 0.92A 3ekwB-5k0yS:
undetectable		 3ekwB-5k0yS:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 6 GLY S 422
THR S 426
GLU S 452
GLU S 379
 None
 1.02A 3fpjA-5k0yS:
undetectable		 3fpjA-5k0yS:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLN S 182
THR S 227
LEU S 391
LEU S 395
GLY S 396
 None
 1.36A 3g1uB-5k0yS:
undetectable		 3g1uB-5k0yS:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5k0y RIBOSOMAL PROTEIN
ES19
(Oryctolagus
cuniculus) 		5 / 12 ALA R  58
ALA R  57
LEU R  28
LEU R  18
ALA R  19
 None
 1.00A 3h0aA-5k0yR:
undetectable		 3h0aA-5k0yR:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.94A 3jvyB-5k0yS:
undetectable		 3jvyB-5k0yS:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.98A 3k4vD-5k0yS:
undetectable		 3k4vD-5k0yS:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 8 VAL S 146
GLY S  58
ILE S 190
GLY S 161
 None
 0.79A 3n9jB-5k0yS:
undetectable		 3n9jB-5k0yS:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.96A 3ndtC-5k0yS:
undetectable		 3ndtC-5k0yS:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.91A 3nduA-5k0yS:
undetectable		 3nduA-5k0yS:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.91A 3nduB-5k0yS:
undetectable		 3nduB-5k0yS:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.94A 3nduC-5k0yS:
undetectable		 3nduC-5k0yS:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		3 / 3 GLN S  52
GLU S 337
LYS S  52
 None
 1.08A 3su9A-5k0yS:
undetectable		 3su9A-5k0yS:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5k0y 40S RIBOSOMAL
PROTEIN S21
(Oryctolagus
cuniculus) 		5 / 12 GLY b  25
VAL b  13
GLY b  57
SER b  31
ALA b  54
 None
 0.97A 3sueC-5k0yb:
undetectable		 3sueC-5k0yb:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		3 / 3 TYR S 115
LEU S 139
LYS S 138
 None
 0.77A 3sueD-5k0yS:
undetectable		 3sueD-5k0yS:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 GLY S 353
ILE S 296
GLY S 294
VAL S 309
ILE S 307
 A  N  75 ( 4.3A)
None
None
None
None
 0.89A 3tkgB-5k0yS:
undetectable		 3tkgB-5k0yS:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT G
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Homo
sapiens;
Oryctolagus
cuniculus) 		3 / 3 ARG T 326
GLU T 277
THR M 132
 None
 0.88A 3v4tA-5k0yT:
2.6		 3v4tA-5k0yT:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		6 / 12 LEU S 269
ILE S 296
ASN S  98
GLY S 351
VAL S 352
GLY S  95
 None
None
None
A  N  75 ( 3.8A)
None
None
 1.38A 4an2A-5k0yS:
undetectable		 4an2A-5k0yS:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 6 LYS S 439
ILE S 440
VAL S 419
LEU S 456
 None
 0.90A 4em2A-5k0yS:
undetectable		 4em2A-5k0yS:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 GLY T 247
GLY T 248
GLY T 249
ALA T 267
GLU T 266
 None
 0.87A 4l8fB-5k0yT:
undetectable		 4l8fB-5k0yT:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 GLY T 247
GLY T 248
GLY T 249
ALA T 267
GLU T 266
 None
 0.85A 4l8fD-5k0yT:
undetectable		 4l8fD-5k0yT:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 4 LEU S 169
ILE S 198
GLY S  58
ILE S 190
 None
 0.87A 5dzk3-5k0yS:
undetectable
5dzkm-5k0yS:
undetectable		 5dzk3-5k0yS:
1.68
5dzkm-5k0yS:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 5 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.82A 5dzkB-5k0yS:
undetectable
5dzkI-5k0yS:
undetectable
5dzkW-5k0yS:
undetectable		 5dzkB-5k0yS:
18.03
5dzkI-5k0yS:
19.26
5dzkW-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 5 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.78A 5dzki-5k0yS:
undetectable
5dzkj-5k0yS:
undetectable
5dzkx-5k0yS:
undetectable		 5dzki-5k0yS:
19.26
5dzkj-5k0yS:
19.26
5dzkx-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 5 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.83A 5dzkd-5k0yS:
undetectable
5dzkk-5k0yS:
undetectable
5dzky-5k0yS:
undetectable		 5dzkd-5k0yS:
18.03
5dzkk-5k0yS:
19.26
5dzky-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		4 / 4 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.79A 5dzkl-5k0yS:
undetectable
5dzkz-5k0yS:
undetectable		 5dzkl-5k0yS:
19.26
5dzkz-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT G
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Homo
sapiens;
Oryctolagus
cuniculus) 		3 / 3 GLN T   7
THR M 120
ASP M 124
 None
 0.91A 5k9dA-5k0yT:
undetectable		 5k9dA-5k0yT:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Oryctolagus
cuniculus) 		3 / 3 HIS P  11
LYS P  12
PHE P  13
 None
 1.36A 5klaA-5k0yP:
undetectable		 5klaA-5k0yP:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT G
(Homo
sapiens) 		4 / 7 TYR O 305
ASP O 254
THR O 250
THR O 253
 None
 1.10A 5ov9A-5k0yO:
undetectable		 5ov9A-5k0yO:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT G
(Homo
sapiens) 		4 / 8 TYR O 305
ASP O 254
THR O 250
THR O 253
 None
 1.16A 5ov9B-5k0yO:
undetectable		 5ov9B-5k0yO:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		3 / 3 LYS T  91
LEU T  89
ARG T  77
 None
 0.91A 5yw0A-5k0yT:
undetectable		 5yw0A-5k0yT:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)
(Oryctolagus
cuniculus) 		5 / 12 LEU S 301
ILE S 296
GLY S 293
LEU S 371
PHE S 328
 None
 1.23A 6a7pA-5k0yS:
undetectable		 6a7pA-5k0yS:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5k0y 40S RIBOSOMAL
PROTEIN S21
(Oryctolagus
cuniculus) 		5 / 12 GLY b  25
VAL b  13
GLY b  57
SER b  31
ALA b  54
 None
 0.97A 6c2mA-5k0yb:
undetectable		 6c2mA-5k0yb:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5k0y 40S RIBOSOMAL
PROTEIN S21
(Oryctolagus
cuniculus) 		5 / 12 GLY b  25
VAL b  13
GLY b  57
SER b  31
ALA b  54
 None
 1.01A 6c2mB-5k0yb:
undetectable		 6c2mB-5k0yb:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT G
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 8 ASP T  73
SER T  71
GLY M 106
SER M 108
 None
 0.59A 6giqL-5k0yT:
undetectable
6giqP-5k0yT:
undetectable
6giqT-5k0yT:
undetectable		 6giqL-5k0yT:
21.79
6giqP-5k0yT:
21.08
6giqT-5k0yT:
11.25