SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ASP A 299
ILE A  64
ALA A  60
ILE A  99
THR A 302
 None
 1.39A 1aj6A-5k10A:
undetectable		 1aj6A-5k10A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ILE A 102
ILE A  64
GLU A 304
ALA A  61
THR A 302
 None
 1.39A 2dtjA-5k10A:
undetectable
2dtjB-5k10A:
undetectable		 2dtjA-5k10A:
20.15
2dtjB-5k10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 THR A  98
ASN A 101
GLY A 104
ILE A  64
 None
 1.02A 3w9tF-5k10A:
undetectable		 3w9tF-5k10A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 325
PHE A 395
ARG A  20
ILE A  21
HIS A 315
 None
None
None
None
NDP  A 501 (-4.7A)
 1.46A 4c49D-5k10A:
undetectable		 4c49D-5k10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ILE A 112
ILE A 117
LEU A 376
ILE A 367
 None
 0.79A 4dtaB-5k10A:
undetectable		 4dtaB-5k10A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 LYS A 374
ASP A 390
ILE A 330
 None
 0.74A 5kc4E-5k10A:
undetectable		 5kc4E-5k10A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		4 / 5 TYR A 235
SER A 196
ALA A 193
GLN A 228
 None
 0.91A 5n0tA-5k10A:
3.0		 5n0tA-5k10A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLN A  14
GLY A  15
ILE A  21
GLN A 320
 None
 1.07A 5vlmD-5k10A:
undetectable		 5vlmD-5k10A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens) 		3 / 3 LYS A 126
PRO A 127
LYS A 203
 None
 1.24A 5y9yA-5k10A:
undetectable		 5y9yA-5k10A:
21.28