SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 5 THR A 397
THR A 306
HIS A 298
LEU A 220
 None
 0.96A 1d4fC-5k13A:
undetectable		 1d4fC-5k13A:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
ARG A 276
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
 0.68A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
SER A 287
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
 0.80A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 228
CYH A 235
LEU A 269
ILE A 270
ILE A 273
ARG A 276
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
 0.60A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 228
CYH A 235
LEU A 269
ILE A 270
ILE A 273
SER A 287
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
 0.71A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		3 / 3 LEU A 231
PHE A 286
ARG A 394
 6Q7  A 501 ( 4.3A)
6Q7  A 501 (-4.7A)
None
 0.40A 1xdkF-5k13A:
35.3		 1xdkF-5k13A:
78.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 10 LEU A 356
ALA A 358
LEU A 319
MET A 373
PHE A 374
 None
 1.19A 1xp0A-5k13A:
3.1		 1xp0A-5k13A:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 PHE A 228
CYH A 235
LEU A 269
ARG A 272
ILE A 273
ARG A 276
PHE A 286
SER A 287
GLY A 391
LEU A 398
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
None
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.1A)
None
 0.71A 2lbdA-5k13A:
36.5		 2lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 PHE A 228
LYS A 234
CYH A 235
LEU A 269
ARG A 272
ILE A 273
ARG A 276
PHE A 286
GLY A 391
LEU A 398
 6Q7  A 501 (-3.9A)
None
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
None
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 ( 4.1A)
None
 0.65A 2lbdA-5k13A:
36.5		 2lbdA-5k13A:
82.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 ILE A 273
GLN A 296
LEU A 224
LEU A 231
 6Q7  A 501 ( 3.9A)
None
None
6Q7  A 501 ( 4.3A)
 1.05A 2qqcB-5k13A:
undetectable
2qqcC-5k13A:
undetectable		 2qqcB-5k13A:
15.73
2qqcC-5k13A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 LEU A 224
LEU A 231
ILE A 273
GLN A 296
 None
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 3.9A)
None
 1.01A 2qqcA-5k13A:
undetectable
2qqcF-5k13A:
undetectable		 2qqcA-5k13A:
14.42
2qqcF-5k13A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 LEU A 224
LEU A 231
ILE A 273
GLN A 296
 None
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 3.9A)
None
 0.94A 2qqcG-5k13A:
undetectable
2qqcJ-5k13A:
undetectable		 2qqcG-5k13A:
14.42
2qqcJ-5k13A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 LEU A 224
LEU A 231
ILE A 273
GLN A 296
 None
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 3.9A)
None
 1.06A 2qqcI-5k13A:
undetectable
2qqcL-5k13A:
undetectable		 2qqcI-5k13A:
14.42
2qqcL-5k13A:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 11 PHE A 228
CYH A 235
LEU A 269
ILE A 273
ARG A 276
PHE A 286
SER A 287
PHE A 302
VAL A 395
LEU A 398
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 (-3.5A)
None
 0.67A 3a9eB-5k13A:
36.4		 3a9eB-5k13A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 11 SER A 232
CYH A 235
LEU A 269
ARG A 276
SER A 287
VAL A 395
LEU A 398
 6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-2.9A)
6Q7  A 501 (-3.5A)
None
 0.93A 3a9eB-5k13A:
36.4		 3a9eB-5k13A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 PHE A 249
VAL A 191
LEU A 187
PRO A 247
 None
 1.14A 3bgdB-5k13A:
undetectable		 3bgdB-5k13A:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 LEU A 269
ILE A 273
ARG A 276
GLY A 391
ILE A 410
 6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.1A)
None
 1.35A 3lbdA-5k13A:
36.3		 3lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 228
LEU A 266
LEU A 269
ARG A 276
PHE A 302
GLY A 391
 6Q7  A 501 (-3.9A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.1A)
 0.60A 3lbdA-5k13A:
36.3		 3lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 228
LEU A 266
LEU A 269
SER A 287
PHE A 302
GLY A 391
 6Q7  A 501 (-3.9A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.1A)
 0.83A 3lbdA-5k13A:
36.3		 3lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 228
LEU A 269
ILE A 273
ARG A 276
PHE A 302
GLY A 391
 6Q7  A 501 (-3.9A)
6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.1A)
 0.52A 3lbdA-5k13A:
36.3		 3lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 228
LEU A 269
ILE A 273
SER A 287
PHE A 302
GLY A 391
 6Q7  A 501 (-3.9A)
6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.1A)
 0.75A 3lbdA-5k13A:
36.3		 3lbdA-5k13A:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 11 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
ARG A 276
PHE A 286
SER A 287
LEU A 305
LEU A 398
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.5A)
None
 0.72A 4dm8A-5k13A:
36.2		 4dm8A-5k13A:
87.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 10 LEU A 355
HIS A 195
LEU A 328
ALA A 331
LEU A 246
 None
 1.22A 4p65A-5k13A:
undetectable
4p65B-5k13A:
undetectable
4p65F-5k13A:
undetectable
4p65H-5k13A:
undetectable		 4p65A-5k13A:
7.23
4p65B-5k13A:
15.32
4p65F-5k13A:
15.32
4p65H-5k13A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 THR A 397
THR A 306
HIS A 298
LEU A 220
 None
 0.93A 4pgfA-5k13A:
undetectable		 4pgfA-5k13A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 PHE A 312
THR A 326
ASP A 322
ASP A 323
 None
 1.37A 4qb9D-5k13A:
undetectable		 4qb9D-5k13A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		3 / 3 MET A 321
GLU A 325
LEU A 329
 None
 0.79A 4v2oB-5k13A:
1.2		 4v2oB-5k13A:
15.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 TRP A 225
PHE A 228
LEU A 269
ILE A 273
ARG A 276
SER A 287
PHE A 302
GLY A 391
LEU A 398
 None
6Q7  A 501 (-3.9A)
6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.1A)
None
 0.72A 5m24A-5k13A:
36.8		 5m24A-5k13A:
81.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
ILE A 273
PHE A 286
SER A 287
PHE A 302
VAL A 395
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 (-3.5A)
 0.64A 5uanB-5k13A:
36.1		 5uanB-5k13A:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 PHE A 228
ILE A 270
PHE A 286
PHE A 302
LEU A 305
VAL A 395
 6Q7  A 501 (-3.9A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-4.7A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.5A)
6Q7  A 501 (-3.5A)
 0.70A 5uanB-5k13A:
36.1		 5uanB-5k13A:
65.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 273
ASP A 288
LEU A 290
GLY A 289
ASP A 282
 6Q7  A 501 ( 3.9A)
None
None
None
None
 1.13A 5x66A-5k13A:
undetectable
5x66B-5k13A:
undetectable		 5x66A-5k13A:
26.03
5x66B-5k13A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 5 THR A 397
THR A 306
HIS A 298
LEU A 220
 None
 0.87A 6aphA-5k13A:
undetectable		 6aphA-5k13A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 5 THR A 397
THR A 306
HIS A 298
LEU A 220
 None
 0.85A 6gbnB-5k13A:
undetectable		 6gbnB-5k13A:
19.81