SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 4 ARG B 655
LEU B 462
ASN B 461
VAL B 416
 None
 1.17A 1lqtA-5k1bB:
undetectable		 1lqtA-5k1bB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 4 ARG B 655
LEU B 462
ASN B 461
VAL B 416
 None
 1.20A 1lqtB-5k1bB:
undetectable		 1lqtB-5k1bB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 4 ARG B 655
LEU B 462
ASN B 461
VAL B 416
 None
 1.18A 1lquA-5k1bB:
undetectable		 1lquA-5k1bB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 4 ARG B 655
LEU B 462
ASN B 461
VAL B 416
 None
 1.21A 1lquB-5k1bB:
undetectable		 1lquB-5k1bB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 GLY B  32
ARG B  55
MET B 428
VAL B  33
 None
 1.04A 1rxcC-5k1bB:
undetectable		 1rxcC-5k1bB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 GLY B  49
THR B 317
THR B 316
ARG B  30
GLY B 359
 None
 1.46A 1v54A-5k1bB:
undetectable
1v54B-5k1bB:
undetectable
1v54T-5k1bB:
undetectable		 1v54A-5k1bB:
20.86
1v54B-5k1bB:
15.62
1v54T-5k1bB:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 6 SER B 533
ARG B 527
PHE B 517
ILE B 516
 None
 1.20A 2qeiA-5k1bB:
undetectable		 2qeiA-5k1bB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
 None
 1.22A 2vcvD-5k1bB:
undetectable		 2vcvD-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
 None
 1.27A 2vcvE-5k1bB:
undetectable		 2vcvE-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
 None
 1.25A 2vcvH-5k1bB:
undetectable		 2vcvH-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 LEU B 460
LEU B 390
LEU B 466
ALA B 469
PHE B 507
 None
 1.23A 2vcvI-5k1bB:
undetectable		 2vcvI-5k1bB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_G_CHDG1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 ARG B  30
GLY B 359
GLY B  49
THR B 317
THR B 316
 None
 1.50A 2y69G-5k1bB:
undetectable
2y69N-5k1bB:
undetectable
2y69O-5k1bB:
undetectable		 2y69G-5k1bB:
9.31
2y69N-5k1bB:
20.86
2y69O-5k1bB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_T_CHDT1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 GLY B  49
THR B 317
THR B 316
ARG B  30
GLY B 359
 None
 1.48A 2y69A-5k1bB:
undetectable
2y69B-5k1bB:
undetectable
2y69T-5k1bB:
undetectable		 2y69A-5k1bB:
20.86
2y69B-5k1bB:
15.62
2y69T-5k1bB:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 GLY B  49
THR B 317
THR B 316
ARG B  30
GLY B 359
 None
 1.48A 2zxwA-5k1bB:
undetectable
2zxwB-5k1bB:
undetectable
2zxwT-5k1bB:
undetectable		 2zxwA-5k1bB:
20.86
2zxwB-5k1bB:
15.62
2zxwT-5k1bB:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 ARG B  30
GLY B 359
GLY B  49
THR B 317
THR B 316
 None
 1.49A 3abmG-5k1bB:
undetectable
3abmN-5k1bB:
undetectable
3abmO-5k1bB:
undetectable		 3abmG-5k1bB:
9.01
3abmN-5k1bB:
20.86
3abmO-5k1bB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 LEU B 433
SER B 421
ILE B 516
THR B 513
ALA B 392
 None
 1.30A 3mdtA-5k1bB:
undetectable		 3mdtA-5k1bB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 8 PRO B 514
HIS B  73
SER B  52
ILE B  53
 None
 0.95A 3sfeB-5k1bB:
undetectable
3sfeC-5k1bB:
undetectable		 3sfeB-5k1bB:
13.93
3sfeC-5k1bB:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 VAL B 132
THR B 161
THR B 160
LEU B 113
VAL B  99
 None
 1.11A 3sp9B-5k1bB:
undetectable		 3sp9B-5k1bB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.33A 4c9lA-5k1bB:
undetectable		 4c9lA-5k1bB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.34A 4c9lB-5k1bB:
undetectable		 4c9lB-5k1bB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.33A 4c9oA-5k1bB:
undetectable		 4c9oA-5k1bB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.35A 4c9oB-5k1bB:
undetectable		 4c9oB-5k1bB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		3 / 3 ARG B 476
TRP B 474
ILE B 551
 None
 1.07A 4mwxA-5k1bB:
8.8		 4mwxA-5k1bB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		3 / 4 ARG B 523
GLY B 522
GLU B 519
 None
 0.67A 4z2dB-5k1bB:
undetectable
4z2dC-5k1bB:
undetectable		 4z2dB-5k1bB:
21.13
4z2dC-5k1bB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 5 SER B 173
ARG B 272
GLY B 254
GLU B 253
 None
 1.17A 5cdqA-5k1bB:
undetectable
5cdqB-5k1bB:
undetectable
5cdqC-5k1bB:
undetectable		 5cdqA-5k1bB:
21.77
5cdqB-5k1bB:
16.41
5cdqC-5k1bB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 5 SER B 173
ARG B 272
GLY B 254
GLU B 253
 None
 1.18A 5cdqR-5k1bB:
undetectable
5cdqS-5k1bB:
undetectable
5cdqT-5k1bB:
undetectable		 5cdqR-5k1bB:
21.77
5cdqS-5k1bB:
16.41
5cdqT-5k1bB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 4 CYH B 200
LEU B 143
LEU B 164
ALA B 133
 None
 1.09A 5hpuA-5k1bB:
undetectable
5hpuB-5k1bB:
undetectable		 5hpuA-5k1bB:
3.54
5hpuB-5k1bB:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 GLY B  49
THR B 317
THR B 316
ARG B  30
GLY B 359
 None
 1.49A 5x1bA-5k1bB:
undetectable
5x1bB-5k1bB:
undetectable
5x1bT-5k1bB:
undetectable		 5x1bA-5k1bB:
20.86
5x1bB-5k1bB:
15.62
5x1bT-5k1bB:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 GLY B  49
THR B 317
THR B 316
ARG B  30
GLY B 359
 None
 1.47A 5x1fA-5k1bB:
undetectable
5x1fB-5k1bB:
undetectable
5x1fT-5k1bB:
undetectable		 5x1fA-5k1bB:
20.86
5x1fB-5k1bB:
15.62
5x1fT-5k1bB:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 8 GLU B  72
ARG B 531
THR B 513
PRO B 514
 None
 1.00A 6a4iA-5k1bB:
undetectable		 6a4iA-5k1bB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 GLU B  72
ARG B 531
THR B 513
PRO B 514
 None
 1.21A 6a4iB-5k1bB:
undetectable		 6a4iB-5k1bB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 LEU B 525
VAL B  15
LEU B 470
THR B 545
LEU B 466
 None
 1.18A 6b54A-5k1bB:
undetectable		 6b54A-5k1bB:
17.87